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Molecular Oncology
Volume 1, Issue 1
, Pages 19-25
, June 2007
The role of histone deacetylases (HDACs) in human cancer
References
- . DNA methyltransferase 3b regulates nerve growth factor-induced differentiation of PC12 cells by recruiting histone deacetylase 2. Mol. Cell Biol. 2005;25:751–766
- . SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J. Biol. Chem. 2005;280:10264–10276
- . Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors. Leukemia. 2005;19:1751–1759
- . Retinoblastoma protein recruits histone deacetylase to repress transcription. Nature. 1998;391:597–601
- . Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Cell. 2005;123:437–448
- . Expression profile of histone deacetylase 1 in gastric cancer tissues. Jpn. J. Cancer Res. 2001;92:1300–1304
- . The role of the cell-adhesion molecule E-cadherin as a tumour-suppressor gene. Trends Biochem. Sci. 1999;24:73–76
- . Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science. 2004;305:390–392
- . Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern. J. Biol. Chem. 2004;279:37175–37184
- . CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future. Oncogene. 2002;21:5427–5440
- . The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase. Proc. Natl. Acad. Sci. USA. 1998;95:10493–10498
- . Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat. Genet. 2005;37:391–400
- . Molecular mechanisms of E2F-dependent activation and pRB-mediated repression. J. Cell Sci. 2004;117:2173–2181
- . Hormonal control of androgen receptor function through SIRT1. Mol. Cell Biol. 2006;26:8122–8135
- . FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases. Cancer Res. 2002;62:4916–4921
- . The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev. 2000;14:121–141
- . Microarray profiling of the effects of histone deacetylase inhibitors on gene expression in cancer cell lines. Int. J. Oncol. 2004;24:773–795
- . Histone deacetylase (HDAC) inhibitor activation of p21WAF1 involves changes in promoter-associated proteins, including HDAC1. Proc. Natl. Acad. Sci. USA. 2004;101:1241–1246
- . Cadherin and catenin alterations in human cancer. Genes Chromosomes Cancer. 2002;34:255–268
- . Upregulation and nuclear recruitment of HDAC1 in hormone refractory prostate cancer. Prostate. 2004;59:177–189
- . Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene. Biochem. Biophys. Res. Commun. 2003;309:558–566
- . Identification of novel isoform-selective inhibitors within class I histone deacetylases. J. Pharmacol. Exp. Ther. 2003;307:720–728
- . Inhibition of histone deacetylase 2 increases apoptosis and p21Cip1/WAF1 expression, independent of histone deacetylase 1. Cell Death Differ. 2005;12:395–404
- . Functional consequences of histone modifications. Curr. Opin. Genet. Dev. 2003;13:154–160
- . Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Nat. Rev. Drug Discov. 2002;1:287–299
- . Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat. Genet. 1998;19:187–191
- . Histone deacetylases specifically down-regulate p53-dependent gene activation. J. Biol. Chem. 2000;275:20436–20443
- . Overexpression of histone deacetylase HDAC1 modulates breast cancer progression by negative regulation of estrogen receptor alpha. Int. J. Cancer. 2003;107:353–358
- . Drug insight: Histone deacetylase inhibitors–development of the new targeted anticancer agent suberoylanilide hydroxamic acid. Nat. Clin. Pract. Oncol. 2005;2:150–157
- . Inhibition of histone deacetylase increase cytotoxicity to anticancer drugs targeting DNA. Cancer Res. 2003;63:7291–7300
- . Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation. Proc. Natl. Acad. Sci. USA. 2005;102:1859–1864
- . Targeting histone deacetylase in cancer therapy. Med. Res. Rev. 2006;26:397–413
- . Transcriptional regulation in acute promyelocytic leukaemia. Oncogene. 2001;20:7204–7216
- . Deacetylation of p53 modulates its effect on cell growth and apoptosis. Nature. 2000;408:377–381
- . pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer. Oncogene. 2003;22:3511–3517
- . Histone deacetylase inhibitors. Adv. Cancer Res. 2004;91:137–168
- . Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat. Rev. Cancer. 2006;6:38–51
- . Histone deacetylase inhibitors radiosensitize human melanoma cells by suppressing DNA repair activity. Clin. Cancer Res. 2005;11:4912–4922
- . Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature. 1998;393:386–389
- . Differential expression of selected histone modifier genes in human solid cancers. BMC Genomics. 2006;7:90
- . Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex. Mol. Cell Biol. 2004;24:306–319
- . Histone metabolic pathways and chromatin assembly factors as proliferation markers. Cancer Lett. 2005;220:1–9
- . Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation. PLoS Genet. 2006;2:e40
- . Targeting tumor angiogenesis with histone deacetylase inhibitors: the hydroxamic acid derivative LBH589. Clin. Cancer Res. 2006;12:634–642
- . DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. Nat. Genet. 2000;25:338–342
- . A truncating mutation of HDAC2 in human cancers confers resistance to histone deacetylase inhibition. Nat. Genet. 2006;38:566–569
- . A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors. Proc. Natl. Acad. Sci. USA. 1999;96:4592–4597
- . Antitumor efficacy of FK228, a novel histone deacetylase inhibitor, depends on the effect on expression of angiogenesis factors. Biochem. Pharmacol. 2003;66(6):897–906
- . Histone deacetylation of RB-responsive promoters: requisite for specific gene repression but dispensable for cell cycle inhibition. Mol. Cell Biol. 2003;23:7719–7731
- . Increased expression of histone deacetylase 2 is found in human gastric cancer. APMIS. 2005;113:264–268
- . Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol. Cell. 2004;16:93–105
- . hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell. 2001;107:149–159
- . Complicated tails: histone modifications and the DNA damage response. Cell. 2005;121:973–976
- . Histone deacetylase inhibitors: understanding a new wave of anticancer agents. Int. J. Cancer. 2004;112:171–178
- . Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat. Cell Biol. 2006;8:1025–1031
- . ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex. Proc. Natl. Acad. Sci. USA. 1998;95:10860–10865
- . Histone deacetylase 3 (HDAC3) and other class I HDACs regulate colon cell maturation and p21 expression and are deregulated in human colon cancer. J. Biol. Chem. 2006;281:13548–13558
- . Histone acetylation and gastrointestinal carcinogenesis. Ann. N. Y. Acad. Sci. 2003;983:220–231
- . Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J. 2004;23:2369–2380
- . HDAC6 expression is correlated with better survival in breast cancer. Clin. Cancer Res. 2004;10:6962–6968
- Quantitation of HDAC1 mRNA expression in invasive carcinoma of the breast. Breast Cancer Res. Treat. 2005;94:11–16
- . Induction of HDAc2 expression upon loss of APC in colorectal tumorogenesis. Cancer Cell. 2004;5:455–463
PII: S1574-7891(07)00002-6
doi: 10.1016/j.molonc.2007.01.001
© 2007 Federation of European Biochemical Societies. Published by Elsevier Inc. All rights reserved.
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Molecular Oncology
Volume 1, Issue 1
, Pages 19-25
, June 2007

