Molecular Oncology
Volume 1, Issue 1 , Pages 72-83 , June 2007

Mice thrive without Cdk4 and Cdk2

  • Cédric Barrière

      Affiliations

    • Molecular Oncology, Centro Nacional de Investigaciones Oncológicas, E-28029 Madrid, Spain
    • EA2406 University of Bordeaux 2, F-33076 Bordeaux, France
    • These authors contributed equally to this work.
    • ,
  • David Santamaría

      Affiliations

    • Molecular Oncology, Centro Nacional de Investigaciones Oncológicas, E-28029 Madrid, Spain
    • These authors contributed equally to this work.
    • ,
  • Antonio Cerqueira

      Affiliations

    • Molecular Oncology, Centro Nacional de Investigaciones Oncológicas, E-28029 Madrid, Spain
    • ,
  • Javier Galán

      Affiliations

    • Molecular Oncology, Centro Nacional de Investigaciones Oncológicas, E-28029 Madrid, Spain
    • ,
  • Alberto Martín

      Affiliations

    • Molecular Oncology, Centro Nacional de Investigaciones Oncológicas, E-28029 Madrid, Spain
    • ,
  • Sagrario Ortega

      Affiliations

    • Biotechnology Program, Centro Nacional de Investigaciones Oncológicas, E-28029 Madrid, Spain
    • ,
  • Marcos Malumbres

      Affiliations

    • Molecular Oncology, Centro Nacional de Investigaciones Oncológicas, E-28029 Madrid, Spain
    • ,
  • Pierre Dubus

      Affiliations

    • EA2406 University of Bordeaux 2, F-33076 Bordeaux, France
    • ,
  • Mariano Barbacid

      Affiliations

    • Molecular Oncology, Centro Nacional de Investigaciones Oncológicas, E-28029 Madrid, Spain
    • Corresponding Author InformationCorresponding author. Centro Nacional de Investigaciones Oncológicas (CNIO), Melchor Fernández Almagro 3, E-28029 Madrid, Spain. Tel.: +34 91 2246900; Fax: +34 91 7328033.

Received 22 December 2006 ,Revised 15 February 2007 ,Accepted 15 February 2007.

References 

  1. Adams PD. Regulation of the retinoblastoma tumor suppressor protein by cyclin/cdks. Biochim. Biophys. Acta. 2001;1471:123–133
  2. Aleem E, Kiyokawa H, Kaldis P. Cdc2–Cyclin E complexes regulate the G1/S phase transition. Nat. Cell. Biol. 2005;7:831–836
  3. Berthet C, Aleem E, Coppola V, Tessarollo L, Kaldis P. Cdk2 knockout mice are viable. Curr. Biol. 2003;13:1775–1785
  4. Berthet C, Klarmann KD, Hilton MB, Suh HC, Keller JR, Kiyokawa H, et al. Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation. Dev. Cell. 2006;10:563–573
  5. Dyson N. The regulation of E2F by pRB-family proteins. Genes Dev. 1998;12:2245–2262
  6. Feil R, Brocard J, Mascrez B, LeMeur M, Metzger D, Chambon P. Ligand-activated site-specific recombination in mice. Proc. Natl. Acad. Sci. USA. 1996;93:10887–10890
  7. Guerra C, Mijimolle N, Dhawahir A, Dubus P, Barradas M, Serrano M, et al. Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context. Cancer Cell. 2003;4:111–120
  8. Kozar K, Ciemerych MA, Rebel VI, Shigematsu H, Zagozdzon A, Sicinska E, et al Mouse development and cell proliferation in the absence of D-Cyclins. Cell. 2004;118:477–491
  9. Malumbres M, Barbacid M. Mammalian cyclin-dependent kinases. Trends Biochem. Sci. 2005;30:630–641
  10. Malumbres M, Sotillo R, Santamaria D, Galan J, Cerezo A, Ortega S, et al. Mammalian cells cycle without the D-type Cyclin-dependent kinases Cdk4 and Cdk6. Cell. 2004;118:493–504
  11. Martin J, Hunt SL, Dubus P, Sotillo R, Nehme-Pelluard F, Magnuson MA, et al. Genetic rescue of Cdk4 null mice restores pancreatic β-cell proliferation but not homeostatic cell number. Oncogene. 2003;22:5261–5269
  12. Martín A, Odajima J, Hunt SL, Dubus P, Ortega S, Malumbres M, et al. Cell cycle inhibition and tumor suppression by p21Cip1 and p27Kip1 are independent of Cdk2. Cancer Cell. 2005;7:591–598
  13. Moons DS, Jirawatnotai S, Parlow AF, Gibori G, Kineman RD, Kiyokawa H. Pituitary hypoplasia and lactotroph dysfunction in mice deficient for Cyclin-dependent kinase-4. Endocrinology. 2002;143:3001–3008
  14. Ortega S, Prieto I, Odajima J, Martin A, Dubus P, Sotillo R, et al. Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice. Nat. Genet. 2003;35:25–31
  15. Rane SG, Dubus P, Mettus RV, Galbreath EJ, Boden G, Reddy EP, et al. Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in ß-cell hyperplasia. Nat. Genet. 1999;22:44–52
  16. Rodriguez CI, Buchholz F, Galloway J, Sequerra R, Kasper J, Ayala R, et al. High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP. Nat. Genet. 2000;25:139–140
  17. Schwenk F, Baron U, Rajewsky K. A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res. 1995;23:5080–5081
  18. Sherr CJ, Roberts JM. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 1999;13:1501–1512
  19. Trimarchi JM, Lees JA. Sibling rivalry in the E2F family. Nat. Rev. Mol. Cell. Biol. 2002;3:11–20
  20. Tsutsui T, Hesabi B, Moons DS, Pandolfi PP, Hansel KS, Koff A, et al. Targeted disruption of Cdk4 delays cell cycle entry with enhanced p27Kip1 activity. Mol. Cell. Biol. 1999;19:7011–7019
  21. Ye X, Zhu C, Harper JW. A premature-termination mutation in the Mus musculus cyclin-dependent kinase 3 gene. Proc. Natl. Acad. Sci. USA. 2001;98:1682–1686

PII: S1574-7891(07)00011-7

doi: 10.1016/j.molonc.2007.03.001

Molecular Oncology
Volume 1, Issue 1 , Pages 72-83 , June 2007

Article Tools

* Image Usage & Resolution