Molecular Oncology
Volume 1, Issue 2 , Pages 216-225 , September 2007

Low-volume, high-throughput sandwich immunoassays for profiling plasma proteins in mice: Identification of early-stage systemic inflammation in a mouse model of intestinal cancer

  • Sara Forrester

      Affiliations

    • Van Andel Research Institute, 333 Bostwick, Grand Rapids, MI 49503, USA
    • ,
  • Kenneth E. Hung

      Affiliations

    • Partners Healthcare Center for Genetics and Genomics, Harvard Medical School, Boston, MA 02115, USA
    • ,
  • Rork Kuick

      Affiliations

    • University of Michigan Cancer Center Biostatistics Cores, University of Michigan, Ann Arbor, MI 48109, USA
    • ,
  • Raju Kucherlapati

      Affiliations

    • Partners Healthcare Center for Genetics and Genomics, Harvard Medical School, Boston, MA 02115, USA
    • ,
  • Brian B. Haab

      Affiliations

    • Van Andel Research Institute, 333 Bostwick, Grand Rapids, MI 49503, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 616 234 5268; fax: +1 616 234 5269.

Received 10 April 2007 ,Revised 1 June 2007 ,Accepted 1 June 2007.

References 

  1. Barton BE, Murphy TF. Cancer cachexia is mediated in part by the induction of IL-6-like cytokines from the spleen. Cytokine. 2001;16:251–257
  2. Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002;420:860–867
  3. Dudoit S, Fridlyand J, Speed TP. Comparison of discrimination methods for the classification of tumors using gene expression data. J. Am. Stat. Assoc. 2002;97:77–87
  4. Etzioni R, Urban N, Ramsey S, McIntosh M, Schwartz S, Reid B, et al. The case for early detection. Nat. Rev. Cancer. 2003;3:243–252
  5. Gao WM, Kuick R, Orchekowski RP, Misek DE, Qiu J, Greenberg AK, et al. Distinctive serum protein profiles involving abundant proteins in lung cancer patients based upon antibody microarray analysis. BMC Cancer. 2005;5:110
  6. Geierstanger BH, Saviranta P, Brinker A. Antibody microarrays using resonance light-scattering particles for detection. Methods Mol. Biol. 2006;328:31–50
  7. Haab BB. Applications of antibody array platforms. Curr. Opin. Biotechnol. 2006;17:415–421
  8. Haab BB, Dunham MJ, Brown PO. Protein microarrays for highly parallel detection and quantitation of specific proteins and antibodies in complex solutions. Genome Biol. 2001;2:1–13
  9. Honda N, Lindberg U, Andersson P, Hoffmann S, Takei H. Simultaneous multiple immunoassays in a compact disc-shaped microfluidic device based on centrifugal force. Clin. Chem. 2005;51:1955–1961
  10. Huang R-P, Huang R, Fan Y, Lin Y. Simultaneous detection of multiple cytokines from conditioned media and patient's sera by an antibody-based protein array system. Anal. Biochem. 2001;294:55–62
  11. Hung KE, Kho AT, Sarracino D, Richard LG, Krastins B, Forrester S, et al. Mass spectrometry-based study of the plasma proteome in a mouse intestinal tumor model. J. Proteome Res. 2006;5:1866–1878
  12. Kingsmore SF. Multiplexed protein measurement: technologies and applications of protein and antibody arrays. Nat. Rev. Drug Discov. 2006;5:310–320
  13. Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell. 1996;87:159–170
  14. Ku NO, Mortensen RF. The mouse C-reactive protein (CRP) gene is expressed in response to IL-1 but not IL-6. Cytokine. 1993;5:319–326
  15. Kuick R, Misek DE, Monsma DJ, Webb CP, Wang H, Peterson KJ, et al. Discovery of cancer biomarkers through the use of mouse models. Cancer Lett. 2007;249:40–48
  16. Lai S, Wang S, Luo J, Lee LJ, Yang ST, Madou MJ. Design of a compact disk-like microfluidic platform for enzyme-linked immunosorbent assay. Anal. Chem. 2004;76:1832–1837
  17. Li Y, Reichert WM. Adapting cDNA microarray format to cytokine detection protein arrays. Langmuir. 2003;19:1557–1566
  18. Perlee L, Christiansen J, Dondero R, Grimwade B, Lejnine S, Mullenix M, et al. Development and standardization of multiplexed antibody microarrays for use in quantitative proteomics. Proteome Sci. 2004;2:9
  19. Schweitzer B, Roberts S, Grimwade B, Shao W, Wang M, Fu Q, et al. Multiplexed protein profiling on microarrays by rolling-circle amplification. Nat. Biotechnol. 2002;20:359–365
  20. Shaw AT, Kirsch DG, Jacks T. Future of early detection of lung cancer: the role of mouse models. Clin. Cancer Res. 2005;11:4999s–5003s
  21. Sreekumar A, Nyati MK, Varambally S, Barrette TR, Ghosh D, Lawrence TS, et al. Profiling of cancer cells using protein microarrays: discovery of novel radiation-regulated proteins. Cancer Res. 2001;61:7585–7593
  22. Su LK, Kinzler KW, Vogelstein B, Preisinger AC, Moser AR, Luongo C, et al. Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science. 1992;256:668–670
  23. Vignali DA. Multiplexed particle-based flow cytometric assays. J. Immunol. Methods. 2000;243:243–255
  24. Wingren C, Borrebaeck CA. Antibody microarrays: current status and key technological advances. Omics. 2006;10:411–427
  25. Wingren C, Steinhauer C, Ingvarsson J, Persson E, Larsson K, Borrebaeck CA. Microarrays based on affinity-tagged single-chain Fv antibodies: sensitive detection of analyte in complex proteomes. Proteomics. 2005;5:1281–1291

PII: S1574-7891(07)00038-5

doi: 10.1016/j.molonc.2007.06.001

Molecular Oncology
Volume 1, Issue 2 , Pages 216-225 , September 2007

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