Molecular Oncology
Volume 1, Issue 3 , Pages 350-355 , December 2007

Human papillomavirus is a favourable prognostic factor in tonsillar cancer and its oncogenic role is supported by the expression of E6 and E7

  • David Lindquist

      Affiliations

    • Department of Oncology–Pathology, Karolinska Institutet, Cancer Center Karolinska, R8:01, Karolinska University Hospital, 171 76 Stockholm, Sweden
    • These authors contributed equally to the work.
    • ,
  • Mircea Romanitan

      Affiliations

    • Department of Oncology–Pathology, Karolinska Institutet, Cancer Center Karolinska, R8:01, Karolinska University Hospital, 171 76 Stockholm, Sweden
    • These authors contributed equally to the work.
    • ,
  • Lalle Hammarstedt

      Affiliations

    • Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden
    • ,
  • Anders Näsman

      Affiliations

    • Department of Oncology–Pathology, Karolinska Institutet, Cancer Center Karolinska, R8:01, Karolinska University Hospital, 171 76 Stockholm, Sweden
    • ,
  • Hanna Dahlstrand

      Affiliations

    • Department of Oncology–Pathology, Karolinska Institutet, Cancer Center Karolinska, R8:01, Karolinska University Hospital, 171 76 Stockholm, Sweden
    • ,
  • Johan Lindholm

      Affiliations

    • Department of Oncology–Pathology, Karolinska Institutet, Cancer Center Karolinska, R8:01, Karolinska University Hospital, 171 76 Stockholm, Sweden
    • ,
  • Liselotte Onelöv

      Affiliations

    • Department of Oncology–Pathology, Karolinska Institutet, Cancer Center Karolinska, R8:01, Karolinska University Hospital, 171 76 Stockholm, Sweden
    • ,
  • Torbjörn Ramqvist

      Affiliations

    • Department of Oncology–Pathology, Karolinska Institutet, Cancer Center Karolinska, R8:01, Karolinska University Hospital, 171 76 Stockholm, Sweden
    • ,
  • Weimin Ye

      Affiliations

    • Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77 Stockholm, Sweden
    • ,
  • Eva Munck-Wikland

      Affiliations

    • Department of Oto-Rhino-Laryngology, Head and Neck Surgery, Karolinska Institutet, Karolinska University Hospital, 171 76 Stockholm, Sweden
    • ,
  • Tina Dalianis

      Affiliations

    • Department of Oncology–Pathology, Karolinska Institutet, Cancer Center Karolinska, R8:01, Karolinska University Hospital, 171 76 Stockholm, Sweden
    • Corresponding Author InformationCorresponding author. Tel.: +46 8 517 765 83; fax: +46 8 517 766 30.

Received 16 July 2007 ,Revised 24 August 2007 ,Accepted 28 August 2007.

References 

  1. Alani RM, Munger K. Human papillomaviruses and associated malignancies. J. Clin. Oncol. 1998;16:330–337
  2. Andl T, Kahn T, Pfuhl A, Nicola T, Erber R, Conradt C, et al Etiological involvement of oncogenic human papillomavirus in tonsillar squamous cell carcinomas lacking retinoblastoma cell cycle control. Cancer Res. 1998;58:5–13
  3. Bustin SA. Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. J. Mol. Endocrinol. 2000;2:169–193
  4. D'Souza G, Kreimer AR, Viscidi R, Pawlita M, Fakhry C, Koch WM, et al. Case-control study of human papillomavirus and oropharyngeal cancer. N. Engl. J. Med. 2007;356:1944–1956
  5. Dahlgren L, Dahlstrand H, Lindquist D, Hogmo A, Bjornestal L, Lindholm J, et al. Human papillomavirus is more common in base of tongue than in mobile tongue cancer and is a favorable prognostic factor in base of tongue cancer patients. Int. J. Cancer. 2004;112:1015–1019
  6. Dahlgren L, Erlandsson F, Lindquist D, Silfversward C, Hellstrom AC, Dalianis T. Differences in human papillomavirus type may influence clinical outcome in early stage cervical cancer. Anticancer Res. 2006;26:829–832
  7. de Boer MA, Jordanova ES, Kenter GG, Peters AA, Corver WE, Trimbos JB, et al. High human papillomavirus oncogene mRNA expression and not viral DNA load is associated with poor prognosis in cervical cancer patients. Clin. Cancer Res. 2007;13:132–138
  8. Frisch M, Goodman MT. Human papillomavirus-associated carcinomas in Hawaii and the mainland. U.S. Cancer. 2000;88:1464–1469
  9. Gillison ML. Human papillomavirus-associated head and neck cancer is a distinct epidemiologic, clinical, and molecular entity. Semin. Oncol. 2004;31:744–754
  10. Gillison ML, Koch WM, Capone RB, Spafford M, Westra WH, Wu L, et al Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J. Natl. Cancer Inst. 2000;92:709–720
  11. Gillison ML, Shah KV. Human papillomavirus-associated head and neck squamous cell carcinoma: mounting evidence for an etiologic role for human papillomavirus in a subset of head and neck cancers. Curr. Opin. Oncol. 2001;13:183–188
  12. Hammarstedt L, Lindquist D, Dahlstrand H, Romanitan M, Onelöv (Dahlgren) L, Joneberg J, et al. Human papillomavirus as a risk factor for the increase in incidence of tonsillar cancer. Int. J. Cancer. 2006;119:2620–2623
  13. Hammarstedt L, Dahlstrand H, Lindquist D, Onelov L, Ryott M, Luo J, et al. The incidence of tonsillar cancer in Sweden is increasing. Acta Otolaryngol. 2007;127:988–992
  14. Kim SH, Koo BS, Kang S, Park K, Kim H, Lee KR, et al. HPV integration begins in the tonsillar crypt and leads to the alteration of p16, EGFR and c-myc during tumor formation. Int. J. Cancer. 2007;120:1418–1425
  15. Klussmann JP, Weissenborn SJ, Wieland U, Dries V, Kolligs J, Jungehuelsing M, et al. Prevalence, distribution, and viral load of human papillomavirus 16 DNA in tonsillar carcinomas. Cancer. 2001;92:2875–2884
  16. Li W, Thompson CH, O'Brien CJ, McNeil EB, Scolyer RA, Cossart YE, et al. Human papillomavirus positivity predicts favourable outcome for squamous carcinoma of the tonsil. Int. J. Cancer. 2003;106:553–558
  17. Mellin H, Friesland S, Lewensohn R, Dalianis T, Munck-Wikland E. Human papillomavirus (HPV) DNA in tonsillar cancer: clinical correlates, risk of relapse, and survival. Int. J. Cancer. 2000;89:300–304
  18. Mellin H, Dahlgren L, Munck-Wikland E, Lindholm J, Rabbani H, Kalantari M, et al. Human papillomavirus type 16 is episomal and a high viral load may be correlated to better prognosis in tonsillar cancer. Int. J. Cancer. 2002;102:152–158
  19. Mork J, Lie AK, Glattre E, Hallmans G, Jellum E, Koskela P, et al. Human papillomavirus infection as a risk factor for squamous-cell carcinoma of the head and neck. N. Engl. J. Med. 2001;344:1125–1131
  20. Ritchie JM, Smith EM, Summersgill KF, Hoffman HT, Wang D, Klussmann JP, et al. Human papillomavirus infection as a prognostic factor in carcinomas of the oral cavity and oropharynx. Int. J. Cancer. 2003;104:336–344
  21. Si HX, Tsao SW, Poon CS, Wang LD, Wong YC, Cheung AL. Viral load of HPV in esophageal squamous cell carcinoma. Int. J. Cancer. 2003;103:496–500
  22. Snijders PJ, Cromme FV, van den Brule AJ, Schrijnemakers HF, Snow GB, Meijer CJ, et al. Prevalence and expression of human papillomavirus in tonsillar carcinomas, indicating a possible viral etiology. Int. J. Cancer. 1992;51:845–850
  23. Syrjanen S. HPV infections and tonsillar carcinoma. J. Clin. Pathol. 2004;57:449–455
  24. van Houten VM, Snijders PJ, van den Brekel MW, Kummer JA, Meijer CJ, van Leeuwen B, et al. Biological evidence that human papillomaviruses are etiologically involved in a subgroup of head and neck squamous cell carcinomas. Int. J. Cancer. 2001;93:232–235
  25. Weinberger PM, Yu Z, Haffty BG, Kowalski D, Harigopal M, Brandsma J, et al. Molecular classification identifies a subset of human papillomavirus–associated oropharyngeal cancers with favorable prognosis. J. Clin. Oncol. 2006;24:736–747
  26. Venuti A, Badaracco G, Rizzo C, Mafera B, Rahimi S, Vigili M. Presence of HPV in head and neck tumours: high prevalence in tonsillar localization. J. Exp. Clin. Cancer Res. 2004;23:561–566
  27. Wiest T, Schwarz E, Enders C, Flechtenmacher C, Bosch FX. Involvement of intact HPV16 E6/E7 gene expression in head and neck cancers with unaltered p53 status and perturbed pRb cell cycle control. Oncogene. 2002;21:1510–1507

PII: S1574-7891(07)00068-3

doi: 10.1016/j.molonc.2007.08.005

Molecular Oncology
Volume 1, Issue 3 , Pages 350-355 , December 2007

Article Tools

* Image Usage & Resolution