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Molecular Oncology
Volume 1, Issue 4
, Pages 395-405
, April 2008
Human cutaneous melanoma; a review of NRAS and BRAF mutation frequencies in relation to histogenetic subclass and body site
References
- . BRAF and NRAS mutations are frequent in nodular melanoma but are not associated with tumor cell proliferation or patient survival. J. Invest. Dermatol. 2005;125:312–317
- . Transforming ras genes from human melanoma: a manifestation of tumour heterogeneity?. Nature. 1984;308:69–72
- . Analysis of ras oncogenes in malignant melanoma and precursor lesions: correlation of point mutations with differentiation phenotype. Oncogene. 1989;4:1363–1374
- . Detection of mutations in the mitogen-activated protein kinase pathway in human melanoma. Clin. Cancer Res. 2003;9:6419–6425
- . Ras mutations in human melanoma: a marker of malignant progression. J. Invest. Dermatol. 1994;102:285–290
- . Ras genes. Annu. Rev. Biochem. 1987;56:779–827
- . Ras oncogenes in human cancer: a review. Cancer Res. 1989;49:4682–4689
- BRAF and RAS mutations in human lung cancer and melanoma. Cancer Res. 2002;62:6997–7000
- . Point mutations in the N-ras oncogene in malignant melanoma and congenital naevi. Br. J. Dermatol. 1994;131:72–77
- . Cooperative effects of INK4a and ras in melanoma susceptibility in vivo. Genes Dev. 1997;11:2822–2834
- . Growth factors rescue cutaneous melanoma cells from apoptosis induced by knockdown of mutated (V 600 E) B-RAF. Oncogene. 2005;24:6292–6302
- . Use of human tissue to assess the oncogenic activity of melanoma-associated mutations. Nat. Genet. 2005;37:745–749
- . Absence of BRAF and NRAS mutations in uveal melanoma. Cancer Res. 2003;63:5761–5766
- Distinct sets of genetic alterations in melanoma. N. Engl. J. Med. 2005;353:2135–2147
- . Somatic activation of KIT in distinct subtypes of melanoma. J. Clin. Oncol. 2006;24:4340–4346
- BRAF alterations are associated with complex mutational profiles in malignant melanoma. Oncogene. 2004;23:5968–5977
- Mutations of the BRAF gene in human cancer. Nature. 2002;417:949–954
- . The specificity of p53 mutation spectra in sunlight induced human cancers. J. Photochem. Photobiol. B. 1995;28:115–124
- . B-raf exon 15 mutations are common in primary melanoma resection specimens but not associated with clinical outcome. Oncology. 2004;66:411–419
- . A novel N-ras mutation in malignant melanoma is associated with excellent prognosis. Cancer Res. 2001;61:4916–4922
- . Analysis of N- and K-ras mutations in the distinctive tumor progression phases of melanoma. J. Invest. Dermatol. 2001;117:1483–1489
- . Signal transduction pathways and regulation of the mammalian cell cycle: cell type-dependent integration of external signals. In: Stein GS, Baserga R, Giordano A, Denhardt DT editor. The Molecular Basis of Cell Cycle and Growth Control. New York: Wiley; 1998;p. 225–304
- . BRAF oncogenic mutations correlate with progression rather than initiation of human melanoma. Cancer Res. 2003;63:3883–3885
- . Targeting RAS signalling pathways in cancer therapy. Nat. Rev. Cancer. 2003;3:11–22
- . In melanoma, RAS mutations are accompanied by switching signaling from BRAF to CRAF and disrupted cyclic AMP signaling. Cancer Res. 2006;66:9483–9491
- . NRAS and BRAF mutations in melanoma tumours in relation to clinical characteristics: a study based on mutation screening by pyrosequencing. Melanoma Res. 2006;16:471–478
- Absence of BRAF mutations in UV-protected mucosal melanomas. J. Med. Genet. 2004;41:270–272
- . Melanoma and sun exposure: an overview of published studies. Int. J. Cancer. 1997;73:198–203
- . Relevance of ultraviolet-induced N-ras oncogene point mutations in development of primary human cutaneous melanoma. Am. J. Pathol. 1996;149:883–893
- . Frequency of UV-inducible NRAS mutations in melanomas of patients with germline CDKN2A mutations. J. Natl. Cancer Inst. 2003;95:790–798
- . Suppression of oncogenic NRAS by RNA interference induces apoptosis of human melanoma cells. Int. J. Cancer. 2005;115:65–73
- . Examination of mutations in BRAF, NRAS, and PTEN in primary cutaneous melanoma. J. Invest. Dermatol. 2006;126:154–160
- . Analysis of BRAF and N-RAS mutations in metastatic melanoma tissues. Cancer Res. 2003;63:3955–3957
- . Detection of B-RAF and N-RAS mutations in human melanoma. J. Am. Coll. Surg. 2005;200:362–370
- . Biallelic deletions in INK4 in cutaneous melanoma are common and associated with decreased survival. Clin. Cancer Res. 2005;11:2991–2997
- . TNFa blocks apoptosis in melanoma cells when BRAF signalling is inhibited. Cancer Res. 2007;67:122–129
- . Ultraviolet immunosuppression: mechanisms and consequences. Dermatol. Clin. 2006;24:19–25
- . Suppression of BRAF(V599E) in human melanoma abrogates transformation. Cancer Res. 2003;63:5198–5202
- . Ultraviolet radiation and melanoma: a systematic review and analysis of reported sequence variants. Hum. Mutat. 2007;28:578–588
- . Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis. J. Carcinog. 2004;3:6
- . Role of ultraviolet radiation in the induction of melanocytic tumors in hairless mice following 7,12-dimethylbenz(a)anthracene application and ultraviolet irradiation. Cancer Res. 1991;51:4964–4970
- . Site-specific DNA damage induced by UVA radiation in the presence of endogenous photosensitizer. Biol. Chem. 1997;378:1307–1312
- . Analysis of ras mutations in human melanocytic lesions: activation of the ras gene seems to be associated with the nodular type of human malignant melanoma. J. Cancer Res. Clin. Oncol. 1995;121:23–30
- . N-ras mutations are common in melanomas from sun-exposed skin of humans but rare in mucosal membranes or unexposed skin. J. Invest. Dermatol. 1998;111:757–761
- . Involvement of reactive oxygen species in the oxidation of tyrosine and dopa to melanin and in skin tanning. Biochem. Biophys. Res. Commun. 1987;142:265–274
- . Activating BRAF and N-Ras mutations in sporadic primary melanomas: an inverse association with allelic loss on chromosome 9. Oncogene. 2003;22:9217–9224
- . BRAF Mutations in metastatic melanoma: a possible association with clinical outcome. Clin. Cancer Res. 2003;9:3362–3368
- . MC1R germline variants confer risk for BRAF-mutant melanoma. Science. 2006;313:521–522
- . Prevalence of exon 15 BRAF mutations in primary melanoma of the superficial spreading, nodular, acral, and lentigo maligna subtypes. J. Invest. Dermatol. 2005;125:575–579
- . T1799A BRAF mutation is common in PUVA lentigines. J. Invest. Dermatol. 2006;126:1915–1917
- . N-RAS mutations and susceptibility to lymphokine-activated killer (LAK) cells in human melanoma. Melanoma Res. 1994;4:11–19
- . Determinants of BRAF mutations in primary melanomas. J. Natl. Cancer Inst. 2003;95:1878–1890
- . Cell signaling and cancer. Cancer Cell. 2003;4:167–174
- . The RAS/RAF/MEK/ERK and PI3K/AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma. Front Biosci. 2005;10:2986–3001
- . BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature. 2005;436:720–724
- . Hydrogen peroxide generation associated with the oxidations of the eumelanin precursors 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid. Melanoma Res. 1996;6:341–349
- . Screening of N-ras codon 61 mutations in paired primary and metastatic cutaneous melanomas: mutations occur early and persist throughout tumor progression. Clin. Cancer Res. 2002;8:3468–3474
- . NRAS and BRAF mutations arise early during melanoma pathogenesis and are preserved throughout tumor progression. Clin. Cancer Res. 2003;9:6483–6488
- . Activation of N-ras in a human melanoma cell line. Mol. Cell. Biol. 1985;5:582–585
- . The Raf/MEK/ERK pathway: new concepts of activation. Biol. Cell. 2001;93:53–62
- . N-ras mutation in ultraviolet radiation-induced murine skin cancers. Cancer Res. 1992;52:3946–3951
- . Melanoma metastases from patients with hereditary cutaneous malignant melanoma contain a high frequency of N-ras activating mutations. Melanoma Res. 1994;4:169–177
- . Immunohistochemical analysis of the N-ras p21 and the p53 proteins in naevi, primary tumours and metastases of human cutaneous malignant melanoma: increased immunopositivity in hereditary melanoma. Melanoma Res. 1995;5:101–106
- . A genome-based strategy uncovers frequent BRAF mutations in melanoma. Cancer Cell. 2002;2:5–7
- High frequency of BRAF mutations in nevi. Nat. Genet. 2003;33:19–20
- . BRAF and NRAS mutations in melanoma and melanocytic nevi. Melanoma Res. 2006;16:267–273
- . Frequent alterations of Ras signaling pathway genes in sporadic malignant melanomas. Int. J. Cancer. 2004;109:377–384
- . Renewing the conspiracy theory debate: does Raf function alone to mediate Ras oncogenesis?. Trends Cell Biol. 2004;14:639–647
- . High BRAF mutation frequency does not characterize all melanocytic tumor types. Int. J. Cancer. 2004;111:705–710
- . Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation. Cancer Res. 2003;63:756–759
- . Molecular cloning and the total nucleotide sequence of the human c-Ha-ras-1 gene activated in a melanoma from a Japanese patient. Proc. Natl. Acad. Sci. USA. 1984;81:4771–4775
- . Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature. 2006;441:424–430
- . Understanding Ras: ‘it ain't over ‘til it's over’. Trends Cell Biol. 2000;10:147–154
- . Incidence of BRAF oncogene mutation and clinical relevance for primary cutaneous melanomas. Clin. Cancer Res. 2004;10:1753–1757
- . ras mutations in human melanotic lesions: K-ras activation is a frequent and early event in melanoma development. Oncogene Res. 1989;5:121–127
- . Pyrosequencing as an alternative to single-strand conformation polymorphism analysis for detection of N-ras mutations in human melanoma metastases. Clin. Chem. 2002;48:2164–2170
- . Tandem BRAF mutations in primary invasive melanomas. J. Invest. Dermatol. 2004;122:1245–1250
- . Could BRAF mutations in melanocytic lesions arise from DNA damage induced by ultraviolet radiation?. J. Invest. Dermatol. 2006;126:1693–1696
- . Mapping of UV photoproducts within ras proto-oncogenes in UV-irradiated cells: correlation with mutations in human skin cancer. Oncogene. 1992;7:1729–1736
- . A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants. Science. 1987;238:542–545
- . Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma. J. Invest. Dermatol. 2004;122:337–341
- B-RAF and N-RAS mutations are preserved during short time in vitro propagation and differentially impact prognosis. PLoS one 2. 2007;e236;http://www.plosone.org
- . BRAF mutation: a frequent event in benign, atypical, and malignant melanocytic lesions of the skin. Am. J. Dermatopathol. 2003;25:365–370
- . Activation of N-ras induced by ultraviolet irradiation in vitro. Oncogene Res. 1988;3:9–20
- . N-ras mutations in human cutaneous melanoma from sun-exposed body sites. Mol. Cell Biol. 1989;9:3114–3116
- . V599EB-RAF is an oncogene in melanocytes. Cancer Res. 2004;64:2338–2342
- . Differential oncogenic potential of activated RAS isoforms in melanocytes. Oncogene. 2007;26:4563–4570
- . Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601. Embo J. 2000;19:5429–5439
PII: S1574-7891(07)00104-4
doi: 10.1016/j.molonc.2007.12.003
© 2007 Federation of European Biochemical Societies. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
Molecular Oncology
Volume 1, Issue 4
, Pages 395-405
, April 2008

