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Molecular Oncology
Volume 2, Issue 1
, Pages 41-53
, June 2008
Molecular aspects of tumour hypoxia
References
- . Glucose transporter glut-1 expression correlates with tumor hypoxia and predicts metastasis-free survival in advanced carcinoma of the cervix. Clin. Cancer Res. 2001;7:928–934
- . GLUT-1 and CAIX as intrinsic markers of hypoxia in carcinoma of the cervix: relationship to pimonidazole binding. Int. J. Cancer. 2003;104:85–91
- . Glut3 expression in biopsy specimens of laryngeal carcinoma is associated with poor survival. The Laryngoscope. 2002;112:393–396
- The plasminogen activator inhibitor PAI-1 controls in vivo tumor vascularization by interaction with proteases, not vitronectin. Implications for antiangiogenic strategies. J. Cell Biol. 2001;152:777–784
- . Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients. Cancer Res. 2002;62:2493–2497
- . Quantifying transient hypoxia in human tumor xenografts by flow cytometry. Cancer Res. 2004;64:6183–6189
- . Orally administered pimonidazole to label hypoxic tumor cells. Cancer Res. 2002;62:6827–6830
- . Novel therapeutic target: the PERKs of inhibiting the integrated stress response. Cell Cycle. 2006;5:2874–2877
- . Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res. 1996;56:941–943
- . Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck. Int. J. Radiat. Oncol. Biol. Phys. 1997;38:285–289
- . Osteopontin expression and distribution in human carcinomas. Am. J. Pathol. 1994;145:610–623
- . Tumor hypoxia at the micro-regional level: clinical relevance and predictive value of exogenous and endogenous hypoxic cell markers. Radiother. Oncol. 2003;67:3–15
- . Acivation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer. Lancet Oncol. 2008;9:288–296
- . Osteopontin expression in lung cancer. Lung Cancer (Amsterdam, Netherlands). 1996;15:311–323
- . Correlation of osteopontin protein expression and pathological stage across a wide variety of tumor histologies. Clin. Cancer Res. 2004;10:184–190
- . Evolving role of uPA/uPAR system in human cancers. Cancer Treat. Rev. 2007;
- A phase I multiple dose, dose escalation study of cG250 monoclonal antibody in patients with advanced renal cell carcinoma. Cancer Immun. 2007;7:13
- . In vivo assessment of tumor hypoxia in lung cancer with 60Cu-ATSM. Eur. J. Nucl. Med. Mol. Imaging. 2003;30:844–850
- . Concepts of oxygen transport at the microcirculatory level. Semin. Radiat. Oncol. 1998;8:143–150
- . Hyperbaric oxygen: the Medical Research Council trials and their clinical significance. Br. J. Radiol. 1978;51:888–894
- . Patterns and levels of hypoxia in head and neck squamous cell carcinomas and their relationship to patient outcome. Int. J. Radiat. Oncol. Biol. Phys. 2007;69:1024–1031
- . The biology of VEGF and its receptors. Nat. Med. 2003;9:669–676
- . HIF1-alpha overexpression indicates a good prognosis in early stage squamous cell carcinomas of the oral floor. BMC Cancer. 2005;5:84
- . Identification of a tightly regulated hypoxia-response element in the promoter of human plasminogen activator inhibitor-1. Blood. 2002;99:2077–2083
- SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res. 1999;59:99–106
- . Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy. Int. J. Radiat. Oncol. Biol. Phys. 1988;14:831–838
- . Strict regulation of CAIX(G250/MN) by HIF-1alpha in clear cell renal cell carcinoma. Oncogene. 2004;23:5624–5631
- . Effect of etoposide, carmustine, vincristine, 5-fluorouracil, or methotrexate on radiobiologically oxic and hypoxic cells in a C3H mouse mammary carcinoma in situ. Cancer Chemother. Pharm. 1992;30:277–280
- . The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br. J. Radiol. 1953;28:638–648
- . Vascular endothelial growth factor receptor tyrosine kinase inhibitors vandetanib (ZD6474) and AZD2171 in lung cancer. Clin. Cancer Res. 2007;13:4617–4622
- . American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer. J. Clin. Oncol. 2007;25:5287–5312Official Journal of the American Society of Clinical Oncology
- . Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res. 1996;56:4509–4515
- . Hypoxic cervical cancers with low apoptotic index are highly aggressive. Cancer Res. 1999;59:4525–4528
- . Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J. Natl. Cancer Inst. 2001;93:266–276
- . Colocalization of carbonic anhydrase 9 expression and cell proliferation in human head and neck squamous cell carcinoma. Clin. Cancer Res. 2005;11:97–106
- . Pathophysiologic effects of vascular-targeting agents and the implications for combination with conventional therapies. Cancer Res. 2006;66:11,520–11,539
- . Microenvironmental regulation of cancer development. Curr. Opin. Genet. Dev. 2008;
- Expression of hypoxia-inducible cell-surface transmembrane carbonic anhydrases in human cancer. Am. J. Pathol. 2001;158:905–919
- . The prognostic value of endogenous hypoxia-related markers for head and neck squamous cell carcinomas treated with ARCON. Radiother. Oncol. 2006;79:288–297
- . ARCON: a novel biology-based approach in radiotherapy. Lancet Oncol. 2002;3:728–737
- . ARCON: experience in 215 patients with advanced head-and-neck cancer. Int. J. Radiat. Oncol. Biol. Phys. 2002;52:769–778
- . Pimonidazole binding and tumor vascularity predict for treatment outcome in head and neck cancer. Cancer Res. 2002;62:7066–7074
- Prognostic value of carbonic anhydrase IX and Ki-67 expression in squamous cell carcinoma of the tongue. Jpn. J. Clin. Oncol. 2007;37:812–819
- . Microvascular corrosion casting in the study of tumor vascularity: a review. Scanning Microsc. 1995;9:1233–1244
- . Endogenous markers of two separate hypoxia response pathways (hypoxia inducible factor 2 alpha and carbonic anhydrase 9) are associated with radiotherapy failure in head and neck cancer patients recruited in the CHART randomized trial. J. Clin. Oncol. 2006;24:727–735
- . “Translating” tumor hypoxia: unfolded protein response (UPR)-dependent and UPR-independent pathways. Mol. Cancer Res. 2006;4:423–436
- . Plasminogen activator inhibitor 1 may promote tumour growth through inhibition of apoptosis. Br. J. Cancer. 2000;82:1702–1708
- Expression and prognostic significance of a panel of tissue hypoxia markers in head-and-neck squamous cell carcinomas. Int. J. Radiat. Oncol. Biol. Phys. 2007;69:167–175
- . Identification of osteopontin as a prognostic plasma marker for head and neck squamous cell carcinomas. Clin. Cancer Res. 2003;9:59–67
- . GRP78 induction in cancer: therapeutic and prognostic implications. Cancer Res. 2007;67:3496–3499
- . Direct relationship between radiobiological hypoxia in tumors and monoclonal antibody detection of EF5 cellular adducts. Int. J. Cancer. 1996;67:372–378
- Pooled analysis of prognostic impact of urokinase-type plasminogen activator and its inhibitor PAI-1 in 8377 breast cancer patients. J. Natl. Cancer Inst. 2002;94:116–128
- . Molecular and cellular regulation of glucose transporter (GLUT) proteins in cancer. J. Cell Physiol. 2005;202:654–662
- . Nitric oxide-mediated regulation of chemosensitivity in cancer cells. J. Natl. Cancer Inst. 2001;93:1879–1885
- . Carbonic anhydrase IX expression and tumor oxygenation status do not correlate at the microregional level in locally advanced cancers of the uterine cervix. Clin. Cancer Res. 2005;11:7220–7225
- . Microregional expression of glucose transporter-1 and oxygenation status: lack of correlation in locally advanced cervical cancers. Clin. Cancer Res. 2005;11:2768–2773
- . Lack of correlation between expression of HIF-1alpha protein and oxygenation status in identical tissue areas of squamous cell carcinomas of the uterine cervix. Cancer Res. 2004;64:5876–5881
- . Hypoxia inducible factor-1 independent pathways in tumor angiogenesis. Clin. Cancer Res. 2007;13:5670–5674
- . The potential role of intrinsic hypoxia markers as prognostic variables in cancer. Antioxid. Redox. Signal. 2007;9:1237–1294
- . Interactions of transmembrane carbonic anhydrase, CAIX, with bicarbonate transporters. Am. J. Physiol. Cell Physiol. 2007;293:738–748
- . A factor of importance in the radiosensitivity of tumours. Br. J. Radiol. 1936;IX:606–614
- . Hypoxia in human soft tissue sarcomas: adverse impact on survival and no association with p53 mutations. Br. J. Cancer. 2001;84:1070–1075
- Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study. Radiother. Oncol. 2005;77:18–24
- The prognostic value of pimonidazole and tumour pO2 in human cervix carcinomas after radiation therapy: a prospective international multi-center study. Radiother. Oncol. 2006;80:123–131
- Interlaboratory variation in oxygen tension measurement by Eppendorf “Histograph” and comparison with hypoxic marker. J. Surg. Oncol. 1997;66:30–38
- . Prognostic value of facilitative glucose transporter Glut-1 in oral squamous cell carcinomas treated by surgical resection; results of EORTC Translational Research Fund studies. Eur. J. Cancer. 2004;40:503–507
- . Plasma osteopontin, hypoxia, and response to the hypoxia sensitiser nimorazole in radiotherapy of head and neck cancer: results from the DAHANCA 5 randomised double-blind placebo-controlled trial. Lancet Oncol. 2005;6:757–764
- . A randomized double-blind phase III study of nimorazole as a hypoxic radiosensitizer of primary radiotherapy in supraglottic larynx and pharynx carcinoma. Results of the Danish Head and Neck Cancer Study (DAHANCA) Protocol 5-85. Radiother. Oncol. 1998;46:135–146
- Tirapazamine plus cisplatin versus cisplatin in advanced non-small-cell lung cancer: a report of the international CATAPULT I study group. Cisplatin and tirapazamine in subjects with advanced previously untreated non-small-cell lung tumors. J. Clin. Oncol. 2000;18:1351–1359
- . Imaging oxygenation of human tumours. Eur. Radiol. 2007;17:861–872
- . Expression of HIF-1alpha and Glut-1 in human bladder cancer. Oncol. Rep. 2005;14:909–913
- . Vascular damaging agents. Clin. Oncol. 2007;19:443–456
- . Antiangiogenesis, anti-VEGF(R) and outlook. Recent Results Cancer Res. 2007;176:189–199
- Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism. Mol. Biol. Cell. 2004;15:4841–4853
- . Diagnostic, prognostic and therapeutic implications of carbonic anhydrases in cancer. Br. J. Cancer. 2003;89:2–7
- . Tumor hypoxia imaging with [F-18] fluoromisonidazole positron emission tomography in head and neck cancer. Clin. Cancer Res. 2006;12:5435–5441
- . Comparisons among pimonidazole binding, oxygen electrode measurements, and radiation response in C3H mouse tumors. Radiat. Res. 1999;151:580–589
- . Elevated plasma osteopontin as marker for distant metastases and poor survival in patients with renal cell carcinoma. J. Cancer Res. Clin. 2007;133:643–652
- . Osteopontin: role in cell signaling and cancer progression. Trends Cell Biol. 2006;16:79–87
- . Effects of breathing a hyperoxic hypercapnic gas mixture on blood oxygenation and vascularity of head-and-neck tumors as measured by magnetic resonance imaging. Int. J. Radiat. Oncol. Biol. Phys. 2002;53:1185–1191
- Tirapazamine, cisplatin, and radiation versus fluorouracil, cisplatin, and radiation in patients with locally advanced head and neck cancer: a randomized phase II trial of the Trans-Tasman Radiation Oncology Group (TROG 98.02). J. Clin. Oncol. 2005;23:79–87
- . Role of osteopontin in tumour progression. Br. J. Cancer. 2004;90:1877–1881
- . Identification of a novel glucose transporter-like protein-GLUT-12. Am. J. Physiol. Endocrinol. Metab. 2002;282:E733–E738
- . Prognostic significance of the metastasis-associated protein osteopontin in human breast cancer. Cancer Res. 2002;62:3417–3427
- . Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. New Engl. J. Med. 2006;355:2542–2550
- . Induction of plasminogen activator inhibitor type-1 (PAI-1) by hypoxia and irradiation in human head and neck carcinoma cell lines. BMC Cancer. 2007;7:143
- . Irradiation combined with SU5416: microvascular changes and growth delay in a human xenograft glioblastoma tumor line. Int. J. Radiat. Oncol. Biol. Phys. 2005;61:529–534
- . Hypoxia, clonal selection, and the role of HIF-1 in tumor progression. Crit. Rev. Biochem. Mol. Biol. 2000;35:71–103
- . Evaluation of HIF-1 inhibitors as anticancer agents. Drug Discov. Today. 2007;12:853–859
- . Carbonic anhydrase-9 expression levels and prognosis in human breast cancer: association with treatment outcome. Br. J. Cancer. 2003;89:271–276
- . Radiolabeled antibodies in renal cell carcinoma. Cancer Imaging. 2007;7:179–188The official publication of the International Cancer Imaging Society
- A randomized phase II pharmacokinetic and pharmacodynamic study of indisulam as second-line therapy in patients with advanced non-small cell lung cancer. Clin. Cancer Res. 2007;13:1816–1822
- . Drug resistance and the solid tumor microenvironment. J. Natl. Cancer Inst. 2007;99:1441–1454
- . Comparison of different methods of CAIX quantification in relation to hypoxia in three human head and neck tumor lines. Radiother. Oncol. 2005;76:194–199
- . Treatment resistance of solid tumors: role of hypoxia and anemia. Med. Oncol. 2001;18:243–259
- . Hypoxia-inducible factor 1 is a basic-helix-loop–helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl. Acad. Sci. USA. 1995;92:5510–5514
- . Phase III trial of paclitaxel plus carboplatin with or without tirapazamine in advanced non-small-cell lung cancer: Southwest Oncology Group Trial S0003. J. Clin. Oncol. 2005;23:9097–9104
- . Drug resistance in Chinese hamster ovary cells during recovery from severe hypoxia. J. Natl. Cancer Inst. 1989;81:1235–1240
- . Cells at intermediate oxygen levels can be more important than the “hypoxic fraction” in determining tumor response to fractionated radiotherapy. Radiat. Res. 1997;147:541–550
- Hypoxia-inducible expression of tumor-associated carbonic anhydrases. Cancer Res. 2000;60:7075–7083
- The prognostic significance of preoperative plasma levels of osteopontin in patients with hepatocellular carcinoma. J. Cancer Res. Clin. 2006;132:709–717
- . Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res. 1999;59:5830–5835
PII: S1574-7891(08)00039-2
doi: 10.1016/j.molonc.2008.03.006
© 2008 Federation of European Biochemical Societies. Published by Elsevier Inc. All rights reserved.
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Molecular Oncology
Volume 2, Issue 1
, Pages 41-53
, June 2008

