Molecular Oncology
Volume 3, Issue 1 , Pages 67-76 , February 2009

HBx genotype D represses GSTP1 expression and increases the oxidative level and apoptosis in HepG2 cells

Received 17 September 2008 ,Accepted 15 October 2008.

References 

  1. Dannenberg LO, Edenberg HJ. Epigenetics of gene expression in human hepatoma cells: expression profiling the response to inhibition of DNA methylation and histone deacetylation. BMC Genomics. 2006;7:181
  2. Esteller M, Corn PG, Urena JM, Gabrielson E, Baylin SB, Herman JG. Inactivation of glutathione S-transferase P1 gene by promoter hypermethylation in human neoplasia. Cancer Res. 1998;58:4515–4518
  3. Fiedler N, Quant E, Fink L, Sun J, Schuster R, Gerlich WH, et al. Differential effects on apoptosis induction in hepatocyte lines by stable expression of hepatitis B virus X protein. World J. Gastroenterol. 2006;12:4673–4682
  4. Jung JK, Arora P, Pagano JS, Jang KL. Expression of DNA methyltransferase 1 is activated by hepatitis B virus X protein via a regulatory circuit involving the p16INK4a-cyclin D1-CDK 4/6-pRb-E2F1 pathway. Cancer Res. 2007;67:5771–5778
  5. Lee JO, Kwun HJ, Jung JK, Choi KH, Min DS, Jang KL. Hepatitis B virus X protein represses E-cadherin expression via activation of DNA methyltransferase 1. Oncogene. 2005;24:6617–6625
  6. Liu J, Lian Z, Han S, Waye MM, Wang H, Wu MC, et al Downregulation of E-cadherin by hepatitis B virus X antigen in hepatocellullar carcinoma. Oncogene. 2006;25:1008–1017
  7. Lu YW, Chen WN. Human hepatitis B virus X protein induces apoptosis in HepG2 cells: role of BH3 domain. Biochem. Biophys. Res. Commun. 2005;338:1551–1556
  8. Lu YW, Tan TL, Zhang J, Chen WN. Cellular apoptosis induced by replication of hepatitis B virus: possible link between viral genotype and clinical outcome. Virol. J. 2007;4:117
  9. Miao J, Chen GG, Chun SY, Lai PP. Hepatitis B virus X protein induces apoptosis in hepatoma cells through inhibiting Bcl-xL expression. Cancer Lett. 2006;236:115–124
  10. Park IY, Sohn BH, Yu E, Suh DJ, Chung YH, Lee JH, et al. Aberrant epigenetic modifications in hepatocarcinogenesis induced by hepatitis B virus X protein. Gastroenterology. 2007;132:1476–1494
  11. Sells MA, Chen ML, Acs G. Production of hepatitis B virus particles in Hep G2 cells transfected with cloned hepatitis B virus DNA. Proc. Natl. Acad. Sci. U. S. A. 1987;84:1005–1009
  12. Strange RC, Spiteri MA, Ramachandran S, Fryer AA. Glutathione-S-transferase family of enzymes. Mutat. Res. 2001;482:21–26
  13. Su F, Schneider RJ. Hepatitis B virus HBx protein sensitizes cells to apoptotic killing by tumor necrosis factor alpha. Proc. Natl. Acad. Sci. U. S. A. 1997;94:8744–8749
  14. Su PF, Lee TC, Lin PJ, Lee PH, Jeng YM, Chen CH, et al. Differential DNA methylation associated with hepatitis B virus infection in hepatocellular carcinoma. Int. J. Cancer. 2007;121:1257–1264
  15. Tischoff I, Tannapfe A. DNA methylation in hepatocellular carcinoma. World J. Gastroenterol. 2008;14:1741–1748
  16. Ye L, Dong N, Wang Q, Xu Z, Cai N, Wang H, et al. Progressive changes in hepatoma cells stably transfected with hepatitis B virus X gene. Intervirology. 2008;51:50–58
  17. Zhang YJ, Chen Y, Ahsan H, Lunn RM, Chen SY, Lee PH, et al. Silencing of glutathione S-transferase P1 by promoter hypermethylation and its relationship to environmental chemical carcinogens in hepatocellular carcinoma. Cancer Lett. 2005;221:135–143
  18. Zhang YJ, Wu HC, Shen J, Ahsan H, Tsai WY, Yang HI, et al. Predicting Hepatocellular Carcinoma by Detection of Aberrant Promoter Methylation in Serum DNA. Clin. Cancer Res. 2007;13:2378–2384
  19. Zhong S, Tang MW, Yeo W, Liu C, Lo YM, Johnson PJ. Silencing of GSTP1 gene by CpG island DNA hypermethylation in HBV-associated hepatocellular carcinomas. Clin. Cancer Res. 2002;8:1087–1092
  20. Zhou T, Evans AA, London WT, Xia X, Zou H, Shen F, et al. Glutathione S-transferase expression in hepatitis B virus-associated human hepatocellular carcinogenesis. Cancer Res. 1997;57:2749–2753

PII: S1574-7891(08)00128-2

doi: 10.1016/j.molonc.2008.10.002

Molecular Oncology
Volume 3, Issue 1 , Pages 67-76 , February 2009

Article Tools

* Image Usage & Resolution