Molecular Oncology
Volume 3, Issue 1 , Pages 77-83 , February 2009

Ebselen abrogates TNFα induced pro-inflammatory response in glioblastoma

Received 3 June 2008 ,Revised 24 September 2008 ,Accepted 15 October 2008.

References 

  1. Aggarwal BB. Signalling pathways of the TNF superfamily: a double-edged sword. Nat. Rev. Immunol. 2003 Sep;3(9):745–756
  2. Balbinotti RA, Ribeiro U, Sakai P, Safatle-Ribeiro AV, Balbinotti SS, Scapulatempo C, et al. hMLH1, hMSH2 and cyclooxygenase-2 (cox-2) in sporadic colorectal polyps. Anticancer Res. 2007 Nov–Dec;27(6C):4465–4471
  3. Bellacosa A. Functional interactions and signaling properties of mammalian DNA mismatch repair proteins. Cell Death Differ. 2001 Nov;8(11):1076–1092
  4. Brat DJ, Bellail AC, Van Meir EG. The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis. Neuro Oncol. 2005 Apr;7(2):122–133
  5. Chang CY, Li MC, Liao SL, Huang YL, Shen CC, Pan HC. Prognostic and clinical implication of IL-6 expression in glioblastoma multiforme. J. Clin. Neurosci. 2005 Nov;12(8):930–933
  6. Coussens LM, Werb Z. Inflammation and cancer. Nature. 2002 Dec 19–26;420(6917):860–867
  7. Duan L, Aoyagi M, Tamaki M, Yoshino Y, Morimoto T, Wakimoto H, et al. Impairment of both apoptotic and cytoprotective signalings in glioma cells resistant to the combined use of cisplatin and tumor necrosis factor alpha. Clin. Cancer Res. 2004 Jan 1;10(1 Pt 1):234–243
  8. El-Bayoumy K, Das A, Narayanan B, Narayanan N, Fiala ES, Desai D, et al. Molecular targets of the chemopreventive agent 1,4-phenylenebis (methylene)-selenocyanate in human non-small cell lung cancer. Carcinogenesis. 2006 Jul;27(7):1369–1376
  9. Esteve PO, Chicoine E, Robledo O, Aoudjit F, Descoteaux A, Potworowski EF, et al. Protein kinase C-zeta regulates transcription of the matrix metalloproteinase-9 gene induced by IL-1 and TNF-alpha in glioma cells via NF-kappa B.J. Biol. Chem. 2002 Sep 20;277(38):35150–35155
  10. Gauss KA, Nelson-Overton LK, Siemsen DW, Gao Y, DeLeo FR, Quinn MT. Role of NF-kappaB in transcriptional regulation of the phagocyte NADPH oxidase by tumor necrosis factor-alpha. J. Leukocyte Biol. 2007 Sep;82(3):729–741
  11. Haddad elB, McCluskie K, Birrell MA, Dabrowski D, Pecoraro M, Underwood S, et al. Differential effects of ebselen on neutrophil recruitment, chemokine, and inflammatory mediator expression in a rat model of lipopolysaccharide-induced pulmonary inflammation. J. Immunol. 2002 Jul 15;169(2):974–982
  12. Jaiswal M, LaRusso NF, Burgart LJ, Gores GJ. Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism. Cancer Res. 2000 Jan 1;60(1):184–190
  13. Jozsef L, Filep JG. Selenium-containing compounds attenuate peroxynitrite-mediated NF-kappaB and AP-1 activation and interleukin-8 gene and protein expression in human leukocytes. Free Rad. Biol. Med. 2003 Nov 1;35(9):1018–1027
  14. Karin M, Greten FR. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat. Rev. Immunol. 2005 Oct;5(10):749–759
  15. Kohonen-Corish MR, Daniel JJ, te Riele H, Buffinton GD, Dahlstrom JE. Susceptibility of Msh2-deficient mice to inflammation-associated colorectal tumors. Cancer Res. 2002 Apr 1;62(7):2092–2097
  16. Kopp EB, Ghosh S. NF-kappa B and rel proteins in innate immunity. Adv. Immunol. 1995;58:1–27
  17. Lakka SS, Gondi CS, Yanamandra N, Dinh DH, Olivero WC, Gujrati M, et al. Synergistic down-regulation of urokinase plasminogen activator receptor and matrix metalloproteinase-9 in SNB19 glioblastoma cells efficiently inhibits glioma cell invasion, angiogenesis, and tumor growth. Cancer Res. 2003 May 15;63(10):2454–2461
  18. Li L, Gondi CS, Dinh DH, Olivero WC, Gujrati M, Rao JS. Transfection with anti-p65 intrabody suppresses invasion and angiogenesis in glioma cells by blocking nuclear factor-kappaB transcriptional activity. Clin. Cancer Res. 2007 Apr 1;13(7):2178–2190
  19. Liang Y, Bollen AW, Gupta N. CC chemokine receptor-2A is frequently overexpressed in glioblastoma. J. Neurooncol. 2008 Jan;86(2):153–163
  20. Matsue H, Edelbaum D, Shalhevet D, Mizumoto N, Yang C, Mummert ME, et al. Generation and function of reactive oxygen species in dendritic cells during antigen presentation. J. Immunol. 2003 Sep 15;171(6):3010–3018
  21. Mian BM, Dinney CP, Bermejo CE, Sweeney P, Tellez C, Yang XD, et al. Fully human anti-interleukin 8 antibody inhibits tumor growth in orthotopic bladder cancer xenografts via down-regulation of matrix metalloproteases and nuclear factor-kappaB. Clin. Cancer Res. 2003 Aug 1;9(8):3167–3175
  22. Nakamura Y, Feng Q, Kumagai T, Torikai K, Ohigashi H, Osawa T, et al. Ebselen, a glutathione peroxidase mimetic seleno-organic compound, as a multifunctional antioxidant. Implication for inflammation-associated carcinogenesis. J. Biol. Chem. 2002 Jan 25;277(4):2687–2694
  23. Safrit JT, Bonavida B. Sensitivity of resistant human tumor cell lines to tumor necrosis factor and adriamycin used in combination: correlation between down-regulation of tumor necrosis factor-messenger RNA induction and overcoming resistance. Cancer Res. 1992 Dec 1;52(23):6630–6637
  24. Schewe T. Molecular actions of ebselen—an antiinflammatory antioxidant. Gen. Pharmacol. 1995 Oct;26(6):1153–1169
  25. Sharma V, Joseph C, Ghosh S, Agarwal A, Mishra MK, Sen E. Kaempferol induces apoptosis in glioblastoma cells through oxidative stress. Mol. Cancer Therap. 2007 Sep;6(9):2544–2553
  26. Sharma V, Tewari R, Sk UH, Joseph C, Sen E. Ebselen sensitizes glioblastoma cells to Tumor Necrosis Factor (TNFalpha)-induced apoptosis through two distinct pathways involving NF-kappaB downregulation and Fas-mediated formation of death inducing signaling complex. Int. J. Cancer. 2008 Nov 1;123(9):2204–2212
  27. Shimohashi N, Nakamuta M, Uchimura K, Sugimoto R, Iwamoto H, Enjoji M, et al. Selenoorganic compound, ebselen, inhibits nitric oxide and tumor necrosis factor-alpha production by the modulation of jun-N-terminal kinase and the NF-kappab signaling pathway in rat Kupffer cells. J. Cell Biochem. 2000 Jun 12;78(4):595–606
  28. Tchirkov A, Khalil T, Chautard E, Mokhtari K, Veronese L, Irthum B, et al. Interleukin-6 gene amplification and shortened survival in glioblastoma patients. Br. J. Cancer. 2007 Feb 12;96(3):474–476
  29. Tewari R, Sharma V, Koul N, Sen E. Involvement of Miltefosine mediated ERK activation in glioma cell apoptosis through Fas regulation. J. Neurochem. 2008 Aug 14;107(3):616–627
  30. Tsujimoto M, Yip YK, Vilcek J. Tumor necrosis factor: specific binding and internalization in sensitive and resistant cells. Proc. Natl. Acad. Sci. USA. 1985 Nov;82(22):7626–7630
  31. Wallach D, Varfolomeev EE, Malinin NL, Goltsev YV, Kovalenko AV, Boldin MP. Tumor necrosis factor receptor and Fas signaling mechanisms. Annu. Rev. Immunol. 1999;17:331–367
  32. Williams CS, Mann M, DuBois RN. The role of cyclooxygenases in inflammation, cancer, and development. Oncogene. 1999 Dec 20;18(55):7908–7916
  33. Yamamoto K, Arakawa T, Ueda N, Yamamoto S. Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells. J. Biol. Chem. 1995 Dec 29;270(52):31315–31320
  34. Zhang M, Nomura A, Uchida Y, Iijima H, Sakamoto T, Iishii Y, et al. Ebselen suppresses late airway responses and airway inflammation in guinea pigs. Free Rad. Biol. Med. 2002 Mar 1;32(5):454–464

PII: S1574-7891(08)00129-4

doi: 10.1016/j.molonc.2008.10.004

Molecular Oncology
Volume 3, Issue 1 , Pages 77-83 , February 2009