Molecular Oncology
Volume 3, Issue 1 , Pages 54-66 , February 2009

PCDH24-induced contact inhibition involves downregulation of β-catenin signaling

  • Rui Ose

      Affiliations

    • Laboratory of Medical Genomics, Department of Human Genome Research, Kazusa DNA Research Institute, 2-6-7 Kazusa-Kamatari, Kisarazu, Chiba 292-0818, Japan
    • Graduate School of Pharmaceutical Sciences & Faculty of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba 260-8675, Japan
  • ,
  • Toshihide Yanagawa

      Affiliations

    • Laboratory of Medical Genomics, Department of Human Genome Research, Kazusa DNA Research Institute, 2-6-7 Kazusa-Kamatari, Kisarazu, Chiba 292-0818, Japan
  • ,
  • Shun Ikeda

      Affiliations

    • Laboratory of Medical Genomics, Department of Human Genome Research, Kazusa DNA Research Institute, 2-6-7 Kazusa-Kamatari, Kisarazu, Chiba 292-0818, Japan
  • ,
  • Osamu Ohara

      Affiliations

    • Graduate School of Pharmaceutical Sciences & Faculty of Pharmaceutical Sciences, Chiba University, 1-8-1, Inohana, Chuo-ku, Chiba 260-8675, Japan
    • Laboratory of Genome Technology, Department of Human Genome Research, Kazusa DNA Research Institute, 2-6-7 Kazusa-Kamatari, Kisarazu, Chiba 292-0818, Japan
    • Laboratory for Immunogenomics, Research Center for Allergy and Immunology, The Institute of Physical and Chemical Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan
  • ,
  • Hisashi Koga

      Affiliations

    • Laboratory of Medical Genomics, Department of Human Genome Research, Kazusa DNA Research Institute, 2-6-7 Kazusa-Kamatari, Kisarazu, Chiba 292-0818, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 438 52 3505; fax: +81 438 52 3914.

Received 4 August 2008 ,Revised 14 October 2008 ,Accepted 28 October 2008.

References 

  1. Barrallo-Gimeno A, Nieto MA. The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development. 2005;132:3151–3161
  2. Boon EM, van der Neut R, van de Wetering M, Clevers H, Pals ST. Wnt signaling regulates expression of the receptor tyrosine kinase met in colorectal cancer. Cancer Res. 2002;62:5126–5128
  3. Cheadle C, Vawter MP, Freed WJ, Becker KG. Analysis of microarray data using Z score transformation. J. Mol. Diagn. 2003;5:73–81
  4. Cho E, Feng Y, Rauskolb C, Maitra S, Fehon R, Irvine KD. Delineation of a fat tumor suppressor pathway. Nat. Genet. 2006;38:1142–1150
  5. DasGupta R, Fuchs E. Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation. Development. 1999;126:4557–4568
  6. Dietrich C, Scherwat J, Faust D, Oesch F. Subcellular localization of beta-catenin is regulated by cell density. Biochem. Biophys. Res. Commun. 2002;292:195–199
  7. Esue O, Carson AA, Tseng Y, Wirtz D. A direct interaction between actin and vimentin filaments mediated by the tail domain of vimentin. J. Biol. Chem. 2006;281:30393–30399
  8. Garrod DR, Merritt AJ, Nie Z. Desmosomal cadherins. Curr. Opin. Cell Biol. 2002;14:537–545
  9. Graves TG, Harr MW, Crawford EL, Willey JC. Stable low-level expression of p21WAF1/CIP1 in A549 human bronchogenic carcinoma cell line-derived clones down-regulates E2F1 mRNA and restores cell proliferation control. Mol. Cancer. 2006;5:1
  10. He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, et al. Identification of c-MYC as a target of the APC pathway. Science. 1998;281:1509–1512
  11. Higashi H, Suzuki-Takahashi I, Yoshida E, Nishimura S, Kitagawa M. Expression of p16INK4a suppresses the unbounded and anchorage-independent growth of a glioblastoma cell line that lacks p16INK4a. Biochem. Biophys. Res. Commun. 1997;231:743–750
  12. Jang SI, Kalinin A, Takahashi K, Marekov LN, Steinert PM. Characterization of human epiplakin: RNAi-mediated epiplakin depletion leads to the disruption of keratin and vimentin IF networks. J. Cell Sci. 2005;118:781–793
  13. Karashima T, Watt FM. Interaction of periplakin and envoplakin with intermediate filaments. J. Cell Sci. 2002;115:5027–5037
  14. Katayama S, Tomaru Y, Kasukawa T, Waki K, Nakanishi M, Nakamura M, et al. Antisense transcription in the mammalian transcriptome. Science. 2005;309:1564–1566
  15. Katoh M. Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades. Cancer Biol. Ther. 2006;5:1059–1064
  16. Kerr MK, Martin M, Churchill GA. Analysis of variance for gene expression microarray data. J. Comput. Biol. 2000;7:819–837
  17. Kim YJ, Sauer C, Testa K, Wahl JK, Svoboda RA, Johnson KR, et al. Modulating the strength of cadherin adhesion: evidence for a novel adhesion complex. J. Cell Sci. 2005;118:3883–3894
  18. Koga H, Shimada K, Hara Y, Nagano M, Kohga H, Yokoyama R, et al. A comprehensive approach for establishment of the platform to analyze functions of KIAA proteins: generation and evaluation of anti-mKIAA antibodies. Proteomics. 2004;4:1412–1416
  19. Koga H, Yuasa S, Nagase T, Shimada K, Nagano M, Imai K, et al. A comprehensive approach for establishment of the platform to analyze functions of KIAA proteins II: public release of inaugural version of InGaP database containing gene/protein expression profiles for 127 mouse KIAA genes/proteins. DNA Res. 2004;11:293–304
  20. Kowalczyk AP, Navarro P, Dejana E, Bornslaeger EA, Green KJ, Kopp DS, et al. VE-cadherin and desmoplakin are assembled into dermal microvascular endothelial intercellular junctions: a pivotal role for plakoglobin in the recruitment of desmoplakin to intercellular junctions. J. Cell Sci. 1998;111(Pt 20):3045–3057
  21. Lee JD, Silva-Gagliardi NF, Tepass U, McGlade CJ, Anderson KV. The FERM protein Epb4.1l5 is required for organization of the neural plate and for the epithelial-mesenchymal transition at the primitive streak of the mouse embryo. Development. 2007;134:2007–2016
  22. Levenberg S, Yarden A, Kam Z, Geiger B. p27 is involved in N-cadherin-mediated contact inhibition of cell growth and S-phase entry. Oncogene. 1999;18:869–876
  23. Mann B, Gelos M, Siedow A, Hanski ML, Gratchev A, Ilyas M, et al. Target genes of beta-catenin-T cell-factor/lymphoid-enhancer-factor signaling in human colorectal carcinomas. Proc. Natl. Acad. Sci. U.S.A. 1999;96:1603–1608
  24. Meerson A, Milyavsky M, Rotter V. p53 mediates density-dependent growth arrest. FEBS Lett. 2004;559:152–158
  25. Munemitsu S, Albert I, Souza B, Rubinfeld B, Polakis P. Regulation of intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor protein. Proc. Natl. Acad. Sci. U.S.A. 1995;92:3046–3050
  26. Noseda M, Chang L, McLean G, Grim JE, Clurman BE, Smith LL, et al. Notch activation induces endothelial cell cycle arrest and participates in contact inhibition: role of p21Cip1 repression. Mol. Cell. Biol. 2004;24:8813–8822
  27. Okada T, Lopez-Lago M, Giancotti FG. Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane. J. Cell Biol. 2005;171:361–371
  28. Okazaki N, Takahashi N, Kojima S, Masuho Y, Koga H. Protocadherin LKC, a new candidate for a tumor suppressor of colon and liver cancers, its association with contact inhibition of cell proliferation. Carcinogenesis. 2002;23:1139–1148
  29. Shtutman M, Zhurinsky J, Simcha I, Albanese C, D'Amico M, Pestell R, et al. The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway. Proc. Natl. Acad. Sci. U.S.A. 1999;96:5522–5527
  30. Spurny R, Abdoulrahman K, Janda L, Runzler D, Kohler G, Castanon MJ, et al. Oxidation and nitrosylation of cysteines proximal to the intermediate filament (IF)-binding site of plectin: effects on structure and vimentin binding and involvement in IF collapse. J. Biol. Chem. 2007;282:8175–8187
  31. Stockinger A, Eger A, Wolf J, Beug H, Foisner R. E-cadherin regulates cell growth by modulating proliferation-dependent beta-catenin transcriptional activity. J. Cell Biol. 2001;154:1185–1196
  32. Takahashi K, Murakami M, Yamanaka S. Role of the phosphoinositide 3-kinase pathway in mouse embryonic stem (ES) cells. Biochem. Soc. Trans. 2005;33:1522–1525
  33. Tanoue T, Takeichi M. New insights into Fat cadherins. J. Cell Sci. 2005;118:2347–2353
  34. Toda T, Kimura N. Standardization of protocol for Immobiline 2-D PAGE and construction of 2-D PAGE protein database on World Wide Web home page. Jpn. J. Electroph. 1997;41:13–19
  35. Venkov CD, Link AJ, Jennings JL, Plieth D, Inoue T, Nagai K, et al. A proximal activator of transcription in epithelial–mesenchymal transition. J. Clin. Invest. 2007;117:482–491
  36. Wielenga VJ, Smits R, Korinek V, Smit L, Kielman M, Fodde R, et al. Expression of CD44 in Apc and Tcf mutant mice implies regulation by the WNT pathway. Am. J. Pathol. 1999;154:515–523
  37. Yang LY, Wang W, Peng JX, Yang JQ, Huang GW. Differentially expressed genes between solitary large hepatocellular carcinoma and nodular hepatocellular carcinoma. World J. Gastroenterol. 2004;10:3569–3573
  38. Zegers MM, Forget MA, Chernoff J, Mostov KE, ter Beest MB, Hansen SH. Pak1 and PIX regulate contact inhibition during epithelial wound healing. Embo J. 2003;22:4155–4165
  39. Zhou BP, Hung MC. Wnt, hedgehog and snail: sister pathways that control by GSK-3beta and beta-Trcp in the regulation of metastasis. Cell Cycle. 2005;4:772–776

PII: S1574-7891(08)00131-2

doi: 10.1016/j.molonc.2008.10.005

Molecular Oncology
Volume 3, Issue 1 , Pages 54-66 , February 2009