Molecular Oncology
Volume 3, Issue 2 , Pages 157-164, April 2009

Large-scale genomic analysis of ovarian carcinomas

  • Kylie L. Gorringe

      Affiliations

    • VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    • Department of Pathology, University of Melbourne, Melbourne, Victoria, Australia
    • ,
  • Ian G. Campbell

      Affiliations

    • VBCRC Cancer Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    • Department of Pathology, University of Melbourne, Melbourne, Victoria, Australia
    • Corresponding Author InformationCorrespondence to: Ian Campbell, VBCRC Cancer Research Laboratory, Peter MacCallum Cancer Centre, Locked Bag 1, A'Beckett St., Melbourne, VIC 8006, Australia. Tel.: +61 3 96561803; fax: +61 3 96561411.

Received 21 October 2008; received in revised form 8 December 2008; accepted 11 December 2008. published online 05 January 2009.

Abstract 

Epithelial ovarian cancers are typified by frequent genomic aberrations that have been difficult to unravel. Recently, high-resolution array technologies have provided the first glimpse of the remarkable complexity of these aberrations with some ovarian cancers containing hundreds of copy number breakpoints, micro-deletions and amplifications. Many of these alterations contain cancer-related genes suggesting that the majority is disease-associated and not just the product of random genomic instability. Future developments such as next-generation sequencing and integrated analysis of data from multiple array platforms on large numbers of samples are poised to revolutionise our understanding of this complex disease.

Keywords: Ovarian cancer, SNP, Array, CGH, Copy number, LOH

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PII: S1574-7891(08)00153-1

doi:10.1016/j.molonc.2008.12.005

Molecular Oncology
Volume 3, Issue 2 , Pages 157-164, April 2009

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