Molecular Oncology
Volume 3, Issue 2 , Pages 151-156, April 2009

Molecular profiles of hereditary epithelial ovarian cancers and their implications for the biology of this disease

W. Norman Thornton Division of Gynecologic Oncology, Department of Obstetrics & Gynecology, University of Virginia Health System, Box 800712, Charlottesville, VA 22908, USA

Received 20 November 2008; received in revised form 12 January 2009; accepted 20 January 2009. published online 09 February 2009.

Abstract 

BRCA1 and BRCA2 germline mutations account for the majority of hereditary ovarian cancers and comprise 10% of total cases. Ovarian cancers arising from these mutations exhibit both overlapping and distinct clinical and molecular features. The expression profiles of sporadic ovarian cancers show similarities to those of BRCA1 and BRCA2-related tumors suggesting that BRCA-related pathways may be involved in their development as well. The purpose of this review is to consider the available data on ovarian cancers in the context of other investigations of BRCA-related transcriptional alterations, and highlight areas for future research.

Keywords: BRCA1, BRCA2, Ovarian cancer, Breast cancer, Microarray, Fanconi anemia

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S1574-7891(09)00017-9

doi:10.1016/j.molonc.2009.01.001

Molecular Oncology
Volume 3, Issue 2 , Pages 151-156, April 2009

Article Tools

* Image Usage & Resolution