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Molecular Oncology
Volume 3, Issue 4
, Pages 339-353
, August 2009
Endocytosis, asymmetric cell division, stem cells and cancer: Unus pro omnibus, omnes pro uno
References
- Prospective identification of tumorigenic breast cancer cells. Proc. Natl. Acad. Sci. U.S.A. 2003;100(7):3983–3988
- . Asymmetry of early endosome distribution in C. elegans embryos. PLoS ONE. 2007;2(6):e493
- Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature. 2007;449(7165):1003–1007
- Crypt stem cells as the cells-of-origin of intestinal cancer. Nature. 2009;457(7229):608–611
- Centrosome amplification can initiate tumorigenesis in flies. Cell. 2008;133(6):1032–1042
- Asymmetric cell division within the human hematopoietic stem and progenitor cell compartment: identification of asymmetrically segregating proteins. Blood. 2007;109(12):5494–5501
- . The brain tumor gene negatively regulates neural progenitor cell proliferation in the larval central brain of Drosophila. Development. 2006;133(14):2639–2648
- . Tetraspanins as regulators of protein trafficking. Traffic. 2007;8(2):89–96
- The endocytic protein alpha-adaptin is required for numb-mediated asymmetric cell division in Drosophila. Dev. Cell. 2002;3(2):221–231
- . Asymmetric segregation of the tumor suppressor brat regulates self-renewal in Drosophila neural stem cells. Cell. 2006;124(6):1241–1253
- . Dare to be different: asymmetric cell division in Drosophila, C. elegans and vertebrates. Curr. Biol. 2004;14(16):R674–R685
- . Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science. 2000;289(5476):113–116
- Sara endosomes and the maintenance of Dpp signaling levels across mitosis. Science. 2006;314(5802):1135–1139
- . Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 1997;3(7):730–737
- The tumor suppressors brat and numb regulate transit-amplifying neuroblast lineages in Drosophila. Dev. Cell. 2008;14(4):535–546
- . Notch signalling: a simple pathway becomes complex. Nat. Rev. Mol. Cell Biol. 2006;7(9):678–689
- . Centrosome dysfunction in Drosophila neural stem cells causes tumors that are not due to genome instability. Curr. Biol. 2008;18(16):1209–1214
- . Induction of tumor growth by altered stem-cell asymmetric division in Drosophila melanogaster. Nat. Genet. 2005;37(10):1125–1129
- Asymmetric T lymphocyte division in the initiation of adaptive immune responses. Science. 2007;315(5819):1687–1691
- . Cleavage orientation and the asymmetric inheritance of Notch1 immunoreactivity in mammalian neurogenesis. Cell. 1995;82(4):631–641
- . Why is delta endocytosis required for effective activation of notch?. Dev. Dyn. 2006;235(4):886–894
- Prospero acts as a binary switch between self-renewal and differentiation in Drosophila neural stem cells. Dev. Cell. 2006;11(6):775–789
- Cancer stem cells – perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res. 2006;66(19):9339–9344
- . Stem cells and cancer: two faces of eve. Cell. 2006;124(6):1111–1115
- NUMB controls p53 tumour suppressor activity. Nature. 2008;451(7174):76–80
- Directional delta and notch trafficking in sara endosomes during asymmetric cell division. Nature. 2009;458:1051–1055
- . Organizing cell renewal in the intestine: stem cells, signals and combinatorial control. Nat. Rev. Genet. 2006;7(5):349–359
- . Centrosomes in cellular regulation. Annu. Rev. Cell Dev. Biol. 2005;21:411–434
- Asymmetric Rab 11 endosomes regulate delta recycling and specify cell fate in the Drosophila nervous system. Cell. 2005;122(5):763–773
- . Male and female Drosophila germline stem cells: two versions of immortality. Science. 2007;316(5823):402–404
- Fürthauer, M., Gonzalez-Gaitan, M., Endocytic regulation of notch signalling during development. Traffic 10 (7), 792–802.
- Ganem N.J., Godinho S.A., Pellman D., 2009. A mechanism linking extra centrosomes to chromosomal instability. Nature, in press, doi:10.1038/nature08136.
- . Cell polarity and asymmetric cell division within human hematopoietic stem and progenitor cells. Cell. Tissues Organs. 2008;188(1–2):116–126
- Segregation of lipid raft markers including CD133 in polarized human hematopoietic stem and progenitor cells. Blood. 2004;104(8):2332–2338
- Intercellular transfer to signalling endosomes regulates an ex vivo bone marrow niche. Nat. Cell Biol. 2009;11(3):303–311
- . Spindle orientation, asymmetric division and tumour suppression in Drosophila stem cells. Nat. Rev. Genet. 2007;8(6):462–472
- . The biogenesis of multivesicular endosomes. Nat. Rev. Mol. Cell Biol. 2004;5(4):317–323
- . Control of daughter cell fates during asymmetric division: interaction of numb and notch. Neuron. 1996;17(1):27–41
- . The hallmarks of cancer. Cell. 2000;100(1):57–70
- Mdm2 promotes the rapid degradation of p53. Nature. 1997;387(6630):296–299
- The intracellular region of notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity. Proc. Natl. Acad. Sci. U.S.A. 2008;105(32):11212–11217
- Analysis of notch1 function by in vitro T cell differentiation of Pax5 mutant lymphoid progenitors. J. Immunol. 2004;173(6):3935–3944
- . Numb and alpha-adaptin regulate sanpodo endocytosis to specify cell fate in Drosophila external sensory organs. EMBO Rep. 2005;6(9):836–842
- . Expression of proneural and neurogenic genes in the zebrafish lateral line primordium correlates with selection of hair cell fate in neuromasts. Mech. Dev. 2001;102(1–2):263–266
- Mind bomb is a ubiquitin ligase that is essential for efficient activation of notch signaling by Delta. Dev. Cell. 2003;4(1):67–82
- Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nat. Genet. 2008;40(11):1291–1299
- Tumor growth need not be driven by rare cancer stem cells. Science. 2007;317(5836):337
- . Mechanisms of asymmetric stem cell division. Cell. 2008;132(4):583–597
- An obligatory role of mind bomb-1 in notch signaling of mammalian development. PLoS ONE. 2007;2(11):e1221
- . Regulation of p53 stability by Mdm2. Nature. 1997;387(6630):299–303
- . Neuralized functions cell-autonomously to regulate a subset of notch-dependent processes during adult Drosophila development. Dev. Biol. 2001;231(1):217–233
- Lethal giant larvae controls the localization of notch-signaling regulators numb, neuralized, and sanpodo in Drosophila sensory-organ precursor cells. Curr. Biol. 2005;15(10):955–962
- A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature. 1994;367(6464):645–648
- . The roles of receptor and ligand endocytosis in regulating notch signaling. Development. 2005;132(8):1751–1762
- Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila. PLoS Biol. 2005;3(4):e96
- . Unequal segregation of neuralized biases notch activation during asymmetric cell division. Dev. Cell. 2003;5(1):139–148
- . Asymmetric cell divisions promote stratification and differentiation of mammalian skin. Nature. 2005;437(7056):275–280
- Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/numb cortical polarity and spindle orientation. Genes Dev. 2006;20(24):3464–3474
- . Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation. Nature. 2006;439(7076):594–598
- Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewal. Dev. Cell. 2006;10(4):441–449
- . Pan-neural Prospero terminates cell proliferation during Drosophila neurogenesis. Genes Dev. 2000;14(2):147–151
- Partner of numb colocalizes with numb during mitosis and directs numb asymmetric localization in Drosophila neural and muscle progenitors. Cell. 1998;95(2):225–235
- . Evidence that stem cells reside in the adult Drosophila midgut epithelium. Nature. 2006;439(7075):475–479
- Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth. Dev. Cell. 2005;9(5):699–710
- . Microenvironmental niches in the bone marrow required for B-cell development. Nat. Rev. Immunol. 2006;6(2):107–116
- Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian stem cell lineage. Nature. 2008;454(7201):241–245
- . Numb controls integrin endocytosis for directional cell migration with aPKC and PAR-3. Dev. Cell. 2007;13(1):15–28
- A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature. 2007;445(7123):106–110
- . Numb inhibits membrane localization of sanpodo, a four-pass transmembrane protein, to promote asymmetric divisions in Drosophila. Dev. Cell. 2003;5(2):231–243
- . The adult Drosophila posterior midgut is maintained by pluripotent stem cells. Nature. 2006;439(7075):470–474
- . Multipotent Drosophila intestinal stem cells specify daughter cell fates by differential notch signaling. Science. 2007;315(5814):988–992
- Presenilin-1, nicastrin, amyloid precursor protein, and gamma-secretase activity are co-localized in the lysosomal membrane. J. Biol. Chem. 2003;278(29):26687–26694
- Neuralized encodes a peripheral membrane protein involved in delta signaling and endocytosis. Dev. Cell. 2001;1(6):807–816
- . Competition between delta and the Abruptex domain of notch. BMC Dev. Biol. 2008;8:4
- Progenitor cell maintenance requires numb and numblike during mouse neurogenesis. Nature. 2002;419(6910):929–934
- Efficient tumour formation by single human melanoma cells. Nature. 2008;456(7222):593–598
- . Self-renewal and cancer of the gut: two sides of a coin. Science. 2005;307(5717):1904–1909
- Functionally unequal centrosomes drive spindle orientation in asymmetrically dividing Drosophila neural stem cells. Dev. Cell. 2007;12(3):467–474
- Identification and expansion of human colon-cancer-initiating cells. Nature. 2007;445(7123):111–115
- . Bmi1 is expressed in vivo in intestinal stem cells. Nat. Genet. 2008;40(7):915–920
- Numb is an endocytic protein. J. Cell Biol. 2000;151(6):1345–1352
- Identification of cells initiating human melanomas. Nature. 2008;451(7176):345–349
- . The TRIM-NHL protein TRIM32 activates microRNAs and prevents self-renewal in mouse neural progenitors. Cell. 2009;136(5):913–925
- . Requirement for dynamin during notch signaling in Drosophila neurogenesis. Dev. Biol. 1997;192(2):585–598
- . Miranda is required for the asymmetric localization of Prospero during mitosis in Drosophila. Cell. 1997;90(3):449–458
- Asymmetric numb distribution is critical for asymmetric cell division of mouse cerebral cortical stem cells and neuroblasts. Development. 2002;129(20):4843–4853
- Identification of human brain tumour initiating cells. Nature. 2004;432(7015):396–401
- . The adult Drosophila malpighian tubules are maintained by multipotent stem cell. Cell Stem Cell. 2007;1:191–203
- The cell fate determinant numb interacts with EHD/Rme-1 family proteins and has a role in endocytic recycling. Mol. Biol. Cell. 2004;15(8):3698–3708
- aPKC-mediated phosphorylation regulates asymmetric membrane localization of the cell fate determinant numb. Embo J. 2007;26(2):468–480
- The behaviour of Drosophila adult hindgut stem cells is controlled by Wnt and Hh signalling. Nature. 2008;454(7204):651–655
- Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila. Dev. Cell. 2005;9(5):711–720
- SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor. Cell. 1998;95(6):779–791
- . The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking. Dev. Cell. 2005;9(5):687–698
- . Live or let die: the cell's response to p53. Nat. Rev. Cancer. 2002;2(8):594–604
- Aurora-A acts as a tumor suppressor and regulates self-renewal of Drosophila neuroblasts. Genes Dev. 2006;20(24):3453–3463
- Polo inhibits progenitor self-renewal and regulates numb asymmetry by phosphorylating Pon. Nature. 2007;449(7158):96–100
- . The emerging shape of the ESCRT machinery. Nat. Rev. Mol. Cell Biol. 2007;8(5):355–368
- . Linking cell cycle to asymmetric division: Aurora-A phosphorylates the Par complex to regulate numb localization. Cell. 2008;135(1):161–173
- . Asymmetric stem cell division: lessons from Drosophila. Semin. Cell Dev. Biol. 2008;19(3):283–293
- . Orientation of asymmetric stem cell division by the APC tumor suppressor and centrosome. Science. 2003;301(5639):1547–1550
- Asymmetric inheritance of mother versus daughter centrosome in stem cell division. Science. 2007;315(5811):518–521
- Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation. Nature. 2009;457(7229):603–607
PII: S1574-7891(09)00077-5
doi: 10.1016/j.molonc.2009.05.006
© 2009 Federation of European Biochemical Societies. Published by Elsevier Inc. All rights reserved.
« Previous
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Molecular Oncology
Volume 3, Issue 4
, Pages 339-353
, August 2009

