Molecular Oncology
Volume 3, Issue 5 , Pages 464-468 , December 2009

Transcription factors down-stream of Ras as molecular indicators for targeting malignancies with oncolytic herpes virus

  • Tuba Esfandyari

      Affiliations

    • The Molecular Medicine Laboratory, Department of Medicine, University of Kansas School of Medicine, 1000 Hixon-Mail Stop: 4037, 3901-Rainbow Blvd., Kansas City, KS 66160, USA
    • ,
  • Ayalew Tefferi

      Affiliations

    • Mayo Clinic Rochester, Rochester, MN, USA
    • ,
  • Anna Szmidt

      Affiliations

    • The Medical University of Vienna, Vienna, Austria
    • ,
  • Tommy Alain

      Affiliations

    • University of Calgary, Cancer Biology Research Group, Calgary, AB, Canada
    • ,
  • Pawel Zwolak

      Affiliations

    • The Medical University of Vienna, Vienna, Austria
    • ,
  • Terra Lasho

      Affiliations

    • Mayo Clinic Rochester, Rochester, MN, USA
    • ,
  • Patrick W. Lee

      Affiliations

    • Dalhousie University, Halifax, NS, Canada
    • ,
  • Faris Farassati

      Affiliations

    • The Molecular Medicine Laboratory, Department of Medicine, University of Kansas School of Medicine, 1000 Hixon-Mail Stop: 4037, 3901-Rainbow Blvd., Kansas City, KS 66160, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 913 945 6823 (office), +1 913 945 6881 (lab); fax: +1 913 945 6923; admin. assistant: +1 913 588 6078.

Received 5 February 2009 ,Revised 16 July 2009 ,Accepted 21 July 2009.

References 

  1. Alain T, Hirasawa K, Pon KJ, Nishikawa SG, Urbanski SJ, Auer Y, et al Reovirus therapy of lymphoid malignancies. Blood. 2002;100:4146–4153
  2. Downward J. Targeting RAS signalling pathways in cancer therapy. Nat. Rev. Cancer. 2003;3:11–22
  3. Farassati F, Lee PW. Ras signalling pathway: a gateway for HSV-1 infection. ScientificWorldJournal. 2003;3:533–535
  4. Farassati F, Pan W, Yamoutpour F, Henke S, Piedra M, Frahm S, et al Ras signaling influences permissiveness of malignant peripheral nerve sheath tumor cells to oncolytic herpes. Am. J. Pathol. 2008;173:1861–1872
  5. Farassati F, Yang AD, Lee PW. Oncogenes in Ras signalling pathway dictate host-cell permissiveness to herpes simplex virus 1. Nat. Cell Biol. 2001;3:745–750
  6. Jazirehi AR, Vega MI, Chatterjee D, Goodglick L, Bonavida B. Inhibition of the Raf-MEK1/2-ERK1/2 signaling pathway, Bcl-xL down-regulation, and chemosensitization of non-Hodgkin's lymphoma B cells by Rituximab. Cancer Res. 2004;64:7117–7126
  7. Kawauchi K, Ogasawara T, Yasuyama M. Activation of extracellular signal-regulated kinase through B-cell antigen receptor in B-cell chronic lymphocytic leukemia. Int. J. Hematol. 2002;75:508–513
  8. Kurland JF, Voehringer DW, Meyn RE. The MEK/ERK pathway acts upstream of NF kappa B1 (p50) homodimer activity and Bcl-2 expression in a murine B-cell lymphoma cell line. MEK inhibition restores radiation-induced apoptosis. J. Biol. Chem. 2003;278:32465–32470
  9. Maclean AR, Brown SM. Herpes Simplex Virus Protocols. vol. 1. Totowa:: Humana Press Inc.; 1998;
  10. Ogasawara T, Yasuyama M, Kawauchi K. Constitutive activation of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase in B-cell lymphoproliferative disorders. Int. J. Hematol. 2003;77:364–370
  11. Parato KA, Senger D, Forsyth PA, Bell JC. Recent progress in the battle between oncolytic viruses and tumours. Nat. Rev. Cancer. 2005;5:965–976
  12. Roberts ML, Cooper NR. Activation of a ras-MAPK-dependent pathway by Epstein–Barr virus latent membrane protein 1 is essential for cellular transformation. Virology. 1998;240:93–99
  13. White CM, Heidenreich O, Nordheim A, Beerman TA. Evaluation of the effectiveness of DNA-binding drugs to inhibit transcription using the c-fos serum response element as a target. Biochemistry. 2000;39:12262–12273
  14. Wilson KE, Li Z, Kara M, Gardner KL, Roberts DD. Beta 1 integrin- and proteoglycan-mediated stimulation of T lymphoma cell adhesion and mitogen-activated protein kinase signaling by thrombospondin-1 and thrombospondin-1 peptides. J. Immunol. 1999;163:3621–3628

PII: S1574-7891(09)00101-X

doi: 10.1016/j.molonc.2009.07.002

Molecular Oncology
Volume 3, Issue 5 , Pages 464-468 , December 2009

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