« Previous
Next »
Molecular Oncology
Volume 4, Issue 2
, Pages 161-168
, April 2010
Aberrations of ERBB2 and TOP2A genes in breast cancer
References
- . Gene amplification in cancer. Trends Genet. 2006;22(8):447–455
- . Chromosome aberrations in solid tumors. Nat. Genet. 2003;34(4):369–376
- . Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma. Proc. Natl. Acad. Sci. USA. 1983;80(6):1707–1711
- . Topoisomerase II alpha amplification may predict benefit from adjuvant anthracyclines in HER2 positive early breast cancer. Breast Cancer Res. Treat. 2007;106(2):181–189
- . Type 1 receptor tyrosine kinase profiles identify patients with enhanced benefit from anthracyclines in the BR9601 adjuvant breast cancer chemotherapy trial. J. Clin. Oncol. 2008;26(31):5027–5035
- . Analysis of ERBB2 and TOP2A gene status using fluorescence in situ hybridization versus immunohistochemistry in localized breast cancer. Neoplasma. 2006;53(5):393–401
- . Does polysomy of chromosome 17 have a role in ERBB2 and topoisomerase IIalpha expression? Gene, mRNA and protein expression: a comprehensive analysis. Tumour Biol. 2007;28(4):221–228
- HER-2 amplification and topoisomerase IIalpha gene aberrations as predictive markers in node-positive breast cancer patients randomly treated either with an anthracycline-based therapy or with cyclophosphamide, methotrexate, and 5-fluorouracil. Clin. Cancer Res. 2002;8(5):1107–1116
- Improved outcome from substituting methotrexate with epirubicin: results from a randomised comparison of CMF versus CEF in patients with primary breast cancer. Eur. J. Cancer. 2007;43(5):877–884
- Topoisomerase II{alpha} amplification does not predict benefit from dose-intense cyclophosphamide, doxorubicin, and fluorouracil therapy in HER2-amplified early breast cancer: results of CALGB 8541/150013. J. Clin. Oncol. 2009;27(21):3430–3436
- . The incidence of topoisomerase II-alpha genomic alterations in adenocarcinoma of the breast and their relationship to human epidermal growth factor receptor-2 gene amplification: a fluorescence in situ hybridization study. Hum. Pathol. 2005;36(4):348–356
- Gene copy mapping of the ERBB2/ TOP2A region in breast cancer. Genes Chromosomes Cancer. 2004;40(1):19–31
- . Predictive value of topoisomerase IIalpha and other prognostic factors for epirubicin chemotherapy in advanced breast cancer. Br. J. Cancer. 1998;77(12):2267–2273
- . Characterization of topoisomerase IIα gene amplification and deletion in breast cancer. Genes Chromosomes Cancer. 1999;26:142–150
- . Amplification and deletion of topoisomerase IIα associate with ErbB-2 amplification and affect sensitivity to topoisomerase II inhibitor doxorubicin in breast cancer. Am. J. Pathol. 2000;156(3):839–847
- . Amplification of a 280-kilobase core region at the ERBB2 locus leads to activation of two hypothetical proteins in breast cancer. Am. J. Pathol. 2003;163(5):1979–1984
- Retrospective analysis of topoisomerase IIa amplifications and deletions as predictive markers in primary breast cancer patients randomly assigned to cyclophosphamide, methotrexate, and fluorouracil or cyclophosphamide, epirubicin, and fluorouracil: Danish Breast Cancer Cooperative Group. J. Clin. Oncol. 2005;23(30):7483–7490
- . Prognostic importance of low c-erbB2 expression in breast tumors. J. Natl. Cancer Inst. 1998;90(9):712
- . Comparison of immunohistochemical and fluorescence in situ hybridization assessment for HER-2/neu status in Taiwanese breast cancer patients. Taiwan J. Obstet. Gynecol. 2007;46(2):146–151
- . Alternative mechanisms of gene amplification in human cancers. Genes Chromosomes Cancer. 2004;41(2):125–132
- . Relevance of breast cancer cell lines as models for breast tumours: an update. Breast Cancer Res. Treat. 2004;83(3):249–289
- . Is PTEN loss associated with clinical outcome measures in human prostate cancer? Br. J. Cancer. 2008;99(8):1296–1301
- . The stability of broken ends of chromosomes in Zea mays. Genetics. 1941;26(2):234–282
- . Reporting recommendations for tumor marker prognostic studies (REMARK). J. Natl. Cancer Inst. 2005;97(16):1180–1184
- . Manifestation, mechanisms and mysteries of gene amplifications. Cancer Lett. 2006;232(1):79–89
- . The pattern of gene amplification is determined by the chromosomal location of hairpin-capped breaks. Cell. 2006;125(7):1283–1296
- . Combined use of PNA and DNA for fluorescence in situ hybridization (FISH). In: Nielsen PE editors. Peptide Nucleic Acids: Protocols and Applications. second ed. Norfolk: Horizon Bioscience; 2004;p. 227–260
- . The value of TOP2A gene copy number variation as a biomarker in breast cancer: update of DBCG trial 89D. Acta Oncol. 2008;47(4):725–734
- . Topoisomerase II alpha and responsiveness of breast cancer to adjuvant chemotherapy. J. Natl. Cancer Inst. 2009;101(9):615–618
- . Amplification of HER2 and TOP2A and deletion of TOP2A genes in breast cancer investigated by new FISH probes. Acta Oncol. 2004;43(1):35–42
- Cytogenetic comparison of primary tumors and lymph node metastases in breast cancer patients. Genes Chromosomes Cancer. 1998;22(2):122–129
- . Early appearance and long-term persistence of the submicroscopic extrachromosomal elements (amplisomes) containing the amplified DHFR genes in human cell lines. Proc. Natl. Acad. Sci. USA. 1990;87(8):2955–2959
- . HER-2 and topoisomerase II as predictors of response to chemotherapy. J. Clin. Oncol. 2008;26(5):736–744
- . Molecular-cytogenetic analysis of fragmentation of chromosome 17 in the breast cancer cell line EFM-19. Anticancer Res. 2002;22(4):1987–1992
- . Amplification of the human dihydrofolate reductase gene via double minutes is initiated by chromosome breaks. Proc. Natl. Acad. Sci. USA. 2000;97(14):7921–7926
- . Alterations in the TOP2A and HER2 genes: association with adjuvant anthracycline sensitivity in human breast cancers. J. Natl. Cancer Inst. 2009;101(9):615–618
- . Recent progress in understanding mechanisms of mammalian DNA amplification. Cell. 1989;57(6):901–908
- . Palindromic gene amplification—an evolutionarily conserved role for DNA inverted repeats in the genome. Nat. Rev. Cancer. 2009;9(3):216–224
- . Topoisomerase IIalpha gene amplification predicts favorable treatment response to tailored and dose-escalated anthracycline-based adjuvant chemotherapy in HER-2/neu-amplified breast cancer: Scandinavian Breast Group Trial 9401. J. Clin. Oncol. 2006;24(16):2428–2436
- . Translocation-excision-deletion-amplification mechanism leading to nonsyntenic coamplification of MYC and ATBF1. Genes Chromosomes Cancer. 2006;45(2):107–117
- American Society of Clinical Oncology/College of American Pathologists Guideline Recommendations for human epidermal growth factor receptor 2 testing in breast cancer. J. Clin. Oncol. 2007;25(1):118–145
PII: S1574-7891(09)00138-0
doi: 10.1016/j.molonc.2009.11.001
© 2009 Federation of European Biochemical Societies. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
Molecular Oncology
Volume 4, Issue 2
, Pages 161-168
, April 2010

