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Molecular Oncology
Volume 4, Issue 2
, Pages 126-134
, April 2010
Prep1 (pKnox1)-deficiency leads to spontaneous tumor development in mice and accelerates EμMyc lymphomagenesis: A tumor suppressor role for Prep1
References
- The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature. 1985;318:533–538
- . The homeodomain protein Meis1 is essential for definitive hematopoiesis and vascular patterning in the mouse embryo. Dev. Biol. 2005;280:307–320
- PKNOX-1, a gene encoding Prep1, a new regulator of pbx activity, maps on human chromosome 21q22.3 and murine chromosome 17b/c. Genomics. 1998;15:323–324
- . Prep1, a novel functional partner of Pbx proteins. EMBO J. 1998;17:1423–1433
- . Meis1a suppresses differentiation by G-CSF and promotes proliferation by SCF: potential mechanisms of cooperativity with Hoxa9 in myeloid leukemia. Proc. Natl. Acad. Sci. U.S.A. 2001;98:13120–13125
- . Prep1.1 has essential and unique genetic functions in hindbrain development and neural crest cells differentiation. Development. 2004;131:613–627
- Homeodomain transcription factor Prep1 (pKnox1) is required for hematopoietic stem cells and progenitors activity. Dev. Biol. 2007;311:324–334
- . Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis. Genes Dev. 1999;13:2658–2669
- . A complex site including both Pbx-Hox and Prep-Meis-responsive elements and binding a retinoic acid-inducible ternary Hoxb1-Pbx-Prep1 complex is required for HOXB2 rhombomere 4 expression. Development. 2000;127:155–166
- Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype. Mol. Cell Biol. 2006;26:5650–5662
- Tip60 is a haploinsufficient tumor suppressor required for an oncogene-induced DNA damage response. Nature. 2007;448:1063–1067
- . The Eμ-myc transgenic mouse. A model for high incidence spontaneous lymphoma and leukemia in early B cells. J. Exp. Med. 1988;167:353–371
- Hematopoietic, angiogenic and eye defects in Meis1 mutant animals. EMBO J. 2004;23:450–459
- . Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity. Mol. Cell Biol. 1999;19:5134–5142
- . A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. Cell. 1990;60:547–555
- . Meis 1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1. Proc. Natl. Acad. Sci. U.S.A. 1997;94:14553–14558
- Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nat. Med. 1998;4:844–847
- . Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b. EMBO J. 1998;17:3714–3725
- Frequent co-expression of the HOXA9 and MEIS1 homeobox genes in human myeloid leukemias. Leukemia. 1999;13:1993–1999
- . Meis1, a PBX1-related homeobox gene involved in myeloid leukemia in BXH-2 mice. Mol. Cell Biol. 1995;15:5434–5443
- . Identification of a new family of Pbx-related homeobox genes. Oncogene. 1996;13:2235–2242
- Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor. Cell. 1990;60:535–545
- Mapping a new target region of allelic loss at 21q22 in primary gastric cancer. Cancer Lett. 2000;159:15–21
- Involvement of Prep-1 in the αβTCR T-lymphocytic potential of hematopoietic precursors. Mol. Cell Biol. 2005;25:10768–10781
- Requirement for Pbx1 in skeletal patterning and programming chondrocyte proliferation and differentiation. Development. 2001;128:3543–3557
- . Defining role for Hox genes and their common collaboration with MEIS1 in the induction of AML. Mol. Cell Biol. 2001;21:224–234
- . Progenitors cells immortalized by HoxA9 + Meis1 show much higher leukemogenicity capacity when transplanted in recipient mice than those immortalized with HoxA9 alone. Blood. 2005;106:254–264
- . Chronic myelomonocytic leukemia with t(7;11)(p15;p15) and NUP98/HOXA9 fusion. Cancer Genet. Cytogenet. 1999;115:70–72
- . Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential. Genes Dev. 2007;21:2762–2774
- The genomic landscape of human breast and colorectal cancers. Science. 2007;318:1108–1113
- . Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization. Mol. Cell Biol. 2004;24:617–628
PII: S1574-7891(10)00002-5
doi: 10.1016/j.molonc.2010.01.001
© 2010 Federation of European Biochemical Societies. Published by Elsevier Inc. All rights reserved.
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Molecular Oncology
Volume 4, Issue 2
, Pages 126-134
, April 2010

