Molecular Oncology
Volume 4, Issue 2 , Pages 119-125 , April 2010

Positron emission tomography imaging of DMBA/TPA mouse skin multi-step tumorigenesis

  • Tomo-o Ishikawa

      Affiliations

    • Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    • ,
  • Indracanti Prem Kumar

      Affiliations

    • Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    • ,
  • Hidevaldo B. Machado

      Affiliations

    • Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    • ,
  • Koon-Pong Wong

      Affiliations

    • Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    • ,
  • Donna Kusewitt

      Affiliations

    • The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA
    • ,
  • Sung-Cheng Huang

      Affiliations

    • Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    • ,
  • Susan M. Fischer

      Affiliations

    • The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA
    • ,
  • Harvey R. Herschman

      Affiliations

    • Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    • Department of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA
    • Corresponding Author InformationCorresponding author at: 341 Boyer Hall, UCLA, 611 Charles E. Young Drive East, Los Angeles, CA 90095, USA. Tel.: +1 310 825 8735; fax: +1 310 825 1447.

Received 15 January 2010 ,Revised 23 January 2010 ,Accepted 24 January 2010.

References 

  1. Abbey CK, Borowsky AD, Gregg JP, Cardiff RD, Cherry SR. Preclinical imaging of mammary intraepithelial neoplasia with positron emission tomography. J. Mammary Gland Biol. Neoplasia. 2006;11(2):137–149
  2. Abbey CK, Borowsky AD, McGoldrick ET, Gregg JP, Maglione JE, Cardiff RD, et al. In vivo positron-emission tomography imaging of progression and transformation in a mouse model of mammary neoplasia. Proc. Natl. Acad. Sci. U.S.A. 2004;101(31):11438–11443
  3. Abel EL, Angel JM, Kiguchi K, DiGiovanni J. Multi-stage chemical carcinogenesis in mouse skin: fundamentals and applications. Nat. Protoc. 2009;4(9):1350–1362
  4. Bensaad K, Vousden KH. p53: new roles in metabolism. Trends Cell Biol. 2007;17(6):286–291
  5. Biaglow JE, Cerniglia G, Tuttle S, Bakanauskas V, Stevens C, McKenna G. Effect of oncogene transformation of rat embryo cells on cellular oxygen consumption and glycolysis. Biochem. Biophys. Res. Commun. 1997;235(3):739–742
  6. Blum R, Jacob-Hirsch J, Amariglio N, Rechavi G, Kloog Y. Ras inhibition in glioblastoma down-regulates hypoxia-inducible factor-1alpha, causing glycolysis shutdown and cell death. Cancer Res. 2005;65(3):999–1006
  7. Buerkle A, Weber WA. Imaging of tumor glucose utilization with positron emission tomography. Cancer Metastasis Rev. 2008;27(4):545–554
  8. Cherry SR. Fundamentals of positron emission tomography and applications in preclinical drug development. J. Clin. Pharmacol. 2001;41(5):482–491
  9. Frese KK, Tuveson DA. Maximizing mouse cancer models. Nat. Rev. Cancer. 2007;7(9):645–658
  10. Gambhir SS, Czernin J, Schwimmer J, Silverman DH, Coleman RE, Phelps ME. A tabulated summary of the FDG PET literature. J. Nucl. Med. 2001;42(5 Suppl.):1S–93S
  11. Gillies RJ, Robey I, Gatenby RA. Causes and consequences of increased glucose metabolism of cancers. J. Nucl. Med. 2008;49(Suppl 2):24S–42S
  12. Hennings H, Glick AB, Lowry DT, Krsmanovic LS, Sly LM, Yuspa SH. FVB/N mice: an inbred strain sensitive to the chemical induction of squamous cell carcinomas in the skin. Carcinogenesis. 1993;14(11):2353–2358
  13. Herschman HR. Micro-PET imaging and small animal models of disease. Curr. Opin. Immunol. 2003;15(4):378–384
  14. Kelloff GJ, Hoffman JM, Johnson B, Scher HI, Siegel BA, Cheng EY, et al Progress and promise of FDG-PET imaging for cancer patient management and oncologic drug development. Clin. Cancer Res. 2005;11(8):2785–2808
  15. Kemp CJ. Multistep skin cancer in mice as a model to study the evolution of cancer cells. Semin. Cancer Biol. 2005;15(6):460–473
  16. Kondoh H, Lleonart ME, Gil J, Wang J, Degan P, Peters G, et al. Glycolytic enzymes can modulate cellular life span. Cancer Res. 2005;65(1):177–185
  17. Loening AM, Gambhir SS. AMIDE: a free software tool for multimodality medical image analysis. Mol. Imaging. 2003;2(3):131–137
  18. Ortega AD, Sanchez-Arago M, Giner-Sanchez D, Sanchez-Cenizo L, Willers I, Cuezva JM. Glucose avidity of carcinomas. Cancer Lett. 2009;276(2):125–135
  19. Phelps ME. Inaugural article: positron emission tomography provides molecular imaging of biological processes. Proc. Natl. Acad. Sci. U.S.A. 2000;97(16):9226–9233
  20. Quintanilla M, Brown K, Ramsden M, Balmain A. Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis. Nature. 1986;322(6074):78–80
  21. Thomas-Ahner JM, Wulff BC, Tober KL, Kusewitt DF, Riggenbach JA, Oberyszyn TM. Gender differences in UVB-induced skin carcinogenesis, inflammation, and DNA damage. Cancer Res. 2007;67(7):3468–3474
  22. Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science. 2009;324(5930):1029–1033
  23. Wakabayashi Y, Mao JH, Brown K, Girardi M, Balmain A. Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice. Nature. 2007;445(7129):761–765

PII: S1574-7891(10)00006-2

doi: 10.1016/j.molonc.2010.01.005

Molecular Oncology
Volume 4, Issue 2 , Pages 119-125 , April 2010

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