« Previous
Next »
Molecular Oncology
Volume 4, Issue 3
, Pages 284-300
, June 2010
Molecular basis for therapy resistance
References
- Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet. 2005;365:1687–1717
- . Specific P53 mutations are associated with de novo resistance to doxorubicin in breast cancer patients. Nat. Med. 1996;2:811–814
- . Predictive value of tumour cell proliferation in locally advanced breast cancer treated with neoadjuvant chemotherapy. Eur. J. Cancer. 2003;39:438–446
- . Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis of a randomised trial. Lancet Oncol. 2010;11:55–65
- . Phase II trial of the oral PARP inhibitor Olaparib (AZD2281) in BRCA-deficient advanced ovarian cancer. J. Clin. Oncol. (Suppl.). 2009;27:277s;Abstr 5500
- . Gene expression profiles predict complete pathologic response to neoadjuvant paclitaxel and fluorouracil, doxorubicin, and cyclophosphamide chemotherapy in breast cancer. J. Clin. Oncol. 2004;22:2284–2293
- . Chromosome 17 polysomy (Ch17) as a predictor of anthracycline response: Emerging evidence from the UK NEAT adjuvant breast cancer trial. San Antonio Breast Cancer Symposium. 2008;
- . Pertuzumab and Trastuzumab: re-responses to 2 biological agents in patients with HER2-Positive breast cancer which had previously progressed during therapy with each agent given separately: a new biological and clinical observation. Cancer Res. 2009;69:803S–804S
- . PIK3CA cancer mutations display gender and tissue specificity patterns. Hum. Mutat. 2008;29:284–288
- . A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell. 2007;12:395–402
- . Estrogen-receptor status and outcomes of modern chemotherapy for patients with node-positive breast cancer. JAMA: J. Am. Med. Assoc. 2006;295:1658–1667
- . Effect of mutated TP53 on response of advanced breast cancers to high-dose chemotherapy. Lancet. 2002;360:852–854
- . Gene expression profiling for molecular characterization of inflammatory breast cancer and prediction of response to chemotherapy. Cancer Res. 2004;64:8558–8565
- . Multivariate analysis of survival in inflammatory breast cancer: impact of intensity of chemotherapy in multimodality treatment. Bone Marrow Transplant. 2004;33:913–920
- . Molecular profiling of inflammatory breast cancer: identification of a poor-prognosis gene expression signature. Clin. Cancer Res. 2004;10:6789–6795
- . Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature. 2006;439:353–357
- . Single-agent lapatinib for HER2-overexpressing advanced or metastatic breast cancer that progressed on first- or second-line trastuzumab-containing regimens. Ann. Oncol. 2009;20:1026–1031
- . AKT1(E17K) in human solid tumours. Oncogene. 2008;27:5648–5650
- . Neratinib: an oral, irreversible dual EGFR/HER2 inhibitor for breast and non-small cell lung cancer. Expert Opin. Investig. Drugs. 2009;18:1735–1751
- . Early onset of breast cancer in a group of British black women. Br. J. Cancer. 2008;98:277–281
- . HER-2 signaling and inhibition in breast cancer. Curr. Cancer Drug Targets. 2009;9:419–438
- . Evaluation of ER, PgR, HER-2 and Ki-67 as predictors of response to neoadjuvant anthracycline chemotherapy for operable breast cancer. Br. J. Cancer. 2005;92:147–155
- . Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer. J. Natl. Cancer Inst. 2006;98:1183–1192
- . Pathologic complete response rates in young women with BRCA1-positive breast cancers after neoadjuvant chemotherapy. J. Clin. Oncol. 2010;28:375–379
- . Response to neoadjuvant therapy with cisplatin in BRCA1-positive breast cancer patients. Breast Cancer Res. Treat. 2009;115:359–363
- . Targeted chemotherapy? Platinum in BRCA1-dysfunctional breast cancer. J. Clin. Oncol. 2010;28:361–363
- . The triple negative paradox: primary tumor chemosensitivity of breast cancer subtypes. Clin. Cancer Res. 2007;13:2329–2334
- . Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. JAMA: J. Am. Med. Assoc. 2006;295:2492–2502
- . Cancer-specific high-throughput annotation of somatic mutations: computational prediction of driver missense mutations. Cancer Res. 2009;69:6660–6667
- . Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival. Proc. Natl. Acad. Sci. U.S.A. 2005;102:3738–3743
- . Biologic markers as predictors of clinical outcome from systemic therapy for primary operable breast cancer. J. Clin. Oncol. 1999;17:3058–3063
- . Gene expression profiling for the prediction of therapeutic response to docetaxel in patients with breast cancer. Lancet. 2003;362:362–369
- . Ki67 Index, HER2 Status, and prognosis of patients with luminal B breast cancer. J. Natl. Cancer Inst. 2009;101:736–750
- . Basal-like breast cancer defined by five biomarkers has superior prognostic value then triple-negative phenotype. Clin. Cancer Res. 2008;14:1368–1376
- . CHEK2 mutations affecting kinase activity together with mutations in the TP53 indicate a functional pathway associated with resistance to epirubicin in primary breast cancer. PLOS One. 2008;3:1–15e3062
- . Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. J. Clin. Oncol. 1999;17:2639–2648
- . Response to primary chemotherapy in breast cancer patients with tumors not expressing estrogen and progesterone receptors. Ann. Oncol. 2000;11:1057–1059
- . Time-related effects of estrogen withdrawal on proliferation- and cell death-related events in MCF-7 xenografts. Int. J. Cancer. 1999;81:309–313
- . A comparative study of histopathology, hormone receptors, peanut lectin binding, Ki-6 immunostaining, and nucleolar organizer region-associated proteins in human breast cancer. Cancer. 1991;67:463–471
- . Endocrine consequences of CMF adjuvant therapy in premenopausal and postmenopausal breast cancer patients. Cancer. 1983;51:803–807
- . Relationship Between quantitative estrogen and progesterone receptor expression and human epidermal growth factor receptor 2 (HER-2) status with recurrence in the arimidex, tamoxifen, alone or in combination trial. J. Clin. Oncol. 2008;26:1059–1065
- . Gene expression profiles of multiple breast cancer phenotypes and response to neoadjuvant chemotherapy. Clin. Cancer Res. 2006;12:819–826
- . “Good Old” clinical markers have similar power in breast cancer prognosis as microarray gene expression profilers. Eur. J. Cancer. 2004;40:1837–1841
- . Resistance to therapy caused by intragenic deletion in BRCA2. Nature. 2008;451:1111–1115
- . Outcome signature genes in breast cancer: is there a unique set?. Bioinformatics. 2005;21:171–178
- . Letrozole is more effective neoadjuvant endocrine therapy than tamoxifen for ErbB-1- and/or ErbB-2-positive, estrogen receptor-positive primary breast cancer: Evidence from a phase III randomized trial. J. Clin. Oncol. 2001;19:3808–3816
- . Concordance among gene-expression-based predictors for breast cancer. N. Engl. J. Med. 2006;355:560–569
- . Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature. 2005;434:917–921
- . A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer. Nat. Med. 2009;15:68–74
- . Stromal gene expression predicts clinical outcome in breast cancer. Nat. Med. 2008;14:518–527
- . Relation of number of positive axillary nodes to the prognosis of patients with primary breast cancer. Cancer. 1983;52:1551–1557
- . Relative worth of estrogen or progesterone receptor and pathologic characteristics of differentiation as indicators of prognosis in node negative breast cancer patients: findings from national surgical adjuvant breast and bowel project protocol B-06. J. Clin. Oncol. 1988;6:1076–1087
- . Pathobiology of preoperative chemotherapy - Findings from the National Surgical Adjuvant Breast and Bowel Project (NSABP) protocol B-18. Cancer. 2002;95:681–695
- . Nuclear receptor co-activators and HER-2/neu are upregulated in breast cancer patients during neo-adjuvant treatment with aromatase inhibitors. Br. J. Cancer. 2009;101:1253–1260
- . Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N. Engl. J. Med. 2009;361:123–134
- . TP53 gene mutations predict the response to neoadjuvant treatment with FUMI in locally advanced breast cancer. Clin. Cancer Res. 2003;9:5582–5588
- . Influence of TP53 gene alterations and c-erbB-2 expression on the response to treatment with doxorubicin in locally advanced breast cancer. Cancer Res. 2001;61:2505–2512
- . Growth fractions in breast cancers determined in situ with monoclonal antibody Ki-67. J. Clin. Pathol. 1986;39:977–980
- . Gene expression profiles in paraffin-embedded core biopsy tissue predict response to chemotherapy in women with locally advanced breast cancer. J. Clin. Oncol. 2005;23:7265–7277
- . Prognostic utility of the 21-gene assay in hormone receptor-positive operable breast cancer compared with classical clinicopathologic features. J. Clin. Oncol. 2008;26:4063–4071
- . Gefitinib treatment in hormone-resistant and hormone receptor-negative advanced breast cancer. Ann. Oncol. 2009;20:1813–1817
- . Patterns of somatic mutation in human cancer genomes. Nature. 2007;446:153–158
- . Do ‘basal-like’ breast cancers really exist?. Nat. Rev. Cancer. 2009;9:128–134
- . Changes in gene expression associated with response to neoadjuvant chemotherapy in breast cancer. J. Clin. Oncol. 2005;23:3331–3342
- . Topoisomerase II alpha amplification does not predict benefit from dose-intense cyclophosphamide, doxorubicin, and fluorouracil therapy in HER2-amplified early breast cancer: results of CALGB 8541/150013. J. Clin. Oncol. 2009;27:3430–3436
- . Predictors of resistance to preoperative trastuzumab and vinorelbine for HER2-positive early breast cancer. Clin. Cancer Res. 2007;13:1198–1207
- . Estrogen receptor status by immunohistochemistry is superior to the ligand-binding assay for predicting response to adjuvant endocrine therapy in breast cancer. J. Clin. Oncol. 1999;17:1474–1481
- . Gene-expression profiles in hereditary breast cancer. N. Engl. J. Med. 2001;344:539–548
- . Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol. 2007;8:
- . Pharmacogenomic predictor of sensitivity to preoperative chemotherapy with paclitaxel and fluorouracil, doxorubicin, and cyclophosphamide in breast cancer. J. Clin. Oncol. 2006;24:4236–4244
- . Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines. Breast Cancer Res. Treat. 2009;
- . Point mutational inactivation of the retinoblastoma antioncogene. Science. 1989;243:937–940
- . The molecular portraits of breast tumors are conserved across microarray platforms. BMC Genomics. 2006;7:
- . Response to neo-adjuvant chemotherapy in BRCA1 and BRCA2 related stage III breast cancer. Familial Cancer. 2009;8:173–177
- . Breast cancer subtypes and response to docetaxel in node-positive breast cancer: use of an immunohistochemical definition in the BCIRG 001 trial. J. Clin. Oncol. 2009;27:1168–1176
- . Prediction of docetaxel response in human breast cancer by gene expression profiling. J. Clin. Oncol. 2005;23:422–431
- . Amplification and deletion of topoisomerase II alpha associate with ErbB-2 amplification and affect sensitivity to topoisomerase II inhibitor doxorubicin in breast cancer. Am. J. Pathol. 2000;156:839–847
- . Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for postmenopausal hormone receptor-positive metastatic breast cancer. J. Clin. Oncol. 2009;27:5538–5546
- . Estrogen receptor status and response to polychemotherapy in advanced breast cancer. Cancer. 1980;46:2809–2813
- . The 38th David A. Karnofsky lecture: the paradoxical actions of estrogen in breast cancer – survival or death?. J. Clin. Oncol. 2008;26:3073–3082
- . Ligand-Independent HER2/HER3/PI3K Complex Is Disrupted by Trastuzumab and Is Effectively Inhibited by the PI3K Inhibitor GDC-0941. Cancer Cell. 2009;15:429–440
- . TP53 mutation and p53 overexpression for prediction of response to neoadjuvant treatment in breast cancer patients. Clin. Cancer Res. 2000;6:50–56
- . Mutation of the PIK3CA oncogene in human cancers. Br. J. Cancer. 2006;94:455–459
- . Lapatinib monotherapy in patients with HER2-overexpressing relapsed or refractory inflammatory breast cancer: final results and survival of the expanded HER2+cohort in EGF103009, a phase II study. Lancet Oncol. 2009;10:581–588
- . Long-term outcome after neo-adjuvant chemotherapy for breast cancer in BRCA1/2 carriers. Int. J. Cancer. 2009;125:2236–2238
- . Retrospective analysis of topoisomerase IIa amplifications and deletions as predictive markers in primary breast cancer patients randomly assigned to cyclophosphamide, methotrexate, and fluorouracil or cyclophosphamide, epirubicin, and fluorouracil: Danish Breast Cancer Cooperative Group. J. Clin. Oncol. 2005;23:7483–7490
- . Triple-negative breast cancers express receptors for growth hormone-releasing hormone (GHRH) and respond to GHRH antagonists with growth inhibition. Breast Cancer Res. Treat. 2009;116:273–279
- . Clinical course of breast cancer patients with complete pathologic primary tumor and axillary lymph node response to doxorubicin-based neoadjuvant chemotherapy. J. Clin. Oncol. 1999;17:460–469
- . The majority of triple-negative breast cancer may correspond to basal-like carcinoma, but triple-negative breast cancer is not identical to basal-like carcinoma. Med. Mol. Morphol. 2009;42:128–131
- . Relationship of flow cytometry results to clinical and steroid receptor status in human breast cancer. Breast Cancer Res. 1985;6:113–121
- . A functional Notch-survivin gene signature in basal breast cancer. Breast Cancer Res. 2008;10:
- . Estrogen regulation of apoptosis: how can one hormone stimulate and inhibit?. Breast Cancer Res. 2009;11:
- . Intrinsic mechanism of estradiol-induced apoptosis in breast cancer cells resistant to estrogen deprivation. J. Natl. Cancer Inst. 2005;97:1746–1759
- . Genomic grade index is associated with response to chemotherapy in patients with breast cancer. J. Clin. Oncol. 2009;27:3185–3191
- . Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer. J. Clin. Oncol. 2008;26:1275–1281
- . Sites of distant recurrence and clinical outcomes in patients with metastatic triple-negative breast cancer high incidence of central nervous system metastases. Cancer. 2008;113:2638–2645
- . The effects of estrogens and antiestrogens on hormone-responsive human breast cancer in long-term tissue culture. Cancer Res. 1976;36:4595–4601
- . The relation between estrogen receptors and response rate to cytotoxic chemotherapy in metastatic breast cancer. N. Engl. J. Med. 1978;298:1223–1228
- . Elevated serum HER-2/neu level predicts decreased response to hormone therapy in metastatic breast cancer. J. Clin. Oncol. 2002;20:1467–1472
- . Novel mechanism of lapatinib resistance in HER2-positive breast tumor cells: activation of AXL. Cancer Res. 2009;69:6871–6878
- . Targeted therapy for cancer using PARP inhibitors. Curr. Opin. Pharmacol. 2008;8:363–369
- . p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell. 1993;74:957–967
- . Omission of histologic grading from clinical decision making may result in overuse of adjuvant therapies in breast cancer: Results from a nationwide study. J. Clin. Oncol. 2001;19:28–36
- . Study of suboptimum treatment response: lessons from breast cancer. Lancet Oncol. 2003;4:177–185
- . Genes causing inherited cancer as beacons identifying the mechanisms of chemoresistance. Trends Mol. Med. 2004;10:113–118
- . Breast cancer prognostication and prediction; are we making progress?. Ann. Oncol. 2007;18(Suppl 8):viii3–viii7
- . Breast cancer prognostication and prediction in the postgenomic era. Ann. Oncol. 2007;18:1293–1306
- . Mechanisms of action of endocrine treatment in breast cancer. Crit. Rev. Oncol./Haematol. 1995;21:158–193
- . Genomics in breast cancer – therapeutic implications?. Nat. Clin. Pract. Oncol. 2005;2:26–33
- . High-dose estrogen treatment in postmenopausal breast cancer patients heavily exposed to endocrine therapy. Breast Cancer Res. Treat. 2001;67:111–116
- . A two-gene expression ratio predicts clinical outcome in breast cancer patients treated with tamoxifen. Cancer Cell. 2004;5:607–616
- . DNA repair deficiency as a therapeutic target in cancer. Curr. Opin. Genetics Develop. 2008;18:80–86
- . Estrogen deprivation causes estradiol hypersensitivity in human breast cancer cells. J. Clin. Endocrinol. Metab. 1995;80:2918–2925
- . PI3 kinase activation and response to trastuzumab or lapatinib in HER-2 overexpressing locally advanced breast cancer (LABC). Cancer Res. 2009;69:71S–72S
- . A strong candidate for the breast and ovarian-cancer susceptibility gene brca1. Science. 1994;266:66–71
- . An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival. Proc. Natl. Acad. Sci. U.S.A. 2005;102:13550–13555
- . Simultaneous detection of TOP2A and HER2 gene amplification by multiplex ligation-dependent probe amplification in breast cancer. Mod. Pathol. 2010;23:62–70
- . Correlation of cell-cycle kinetics, hormone receptors, histopathology, and nodal status in human breast cancer. Cancer. 1984;54:1586–1590
- . c-erB-2 expression and response to adjuvant therapy in women with node-positive early Breast cancer. N. Engl. J. Med. 1994;330:1260–1266
- . Target-based agents against ErbB receptors and their ligands: a novel approach to cancer treatment. Endocr. Relat. Cancer. 2003;10:1–21
- . Topoisomerase II alpha and responsiveness of breast cancer to adjuvant chemotherapy. J. Natl. Cancer Inst. 2009;101:644–650
- . A randomized study of lapatinib alone or in combination with trastuzumab in heavily pretreated HER2+ metastatic breast cancer progressing on trastuzumab therapy. J. Clin. Oncol. (Suppl.). 2008;26:44s;Abstr 1015
- . Efficacy of BSI-201, a poly (ADP-ribose) polymerase-1 (PARP1) inhibitor, in combination with gemcitabine/carboplatin (G/C) in patients with metastatic triple-negative breast cancer (TNBC): Results of a randomized phase II trial. J. Clin. Oncol. (Suppl.). 2009;27:793S;Abstr 3
- . A new histological grading system to assess response of breast cancers to primary chemotherapy: prognostic significance and survival. Breast. 2003;12:320–327
- . A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N. Engl. J. Med. 2004;351:2817–2826
- . Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer. J. Clin. Oncol. 2006;24:3726–3734
- . erbB-2 and response to doxorubicin in patients with axillary lymph node-positive, hormone receptor-negative breast cancer. J. Natl. Cancer Inst. 1998;90:1361–1370
- . The molecular pathology of hereditary breast cancer. Pathobiology. 2008;75:85–94
- . Supervised risk predictor of breast cancer based on intrinsic subtypes. J. Clin. Oncol. 2009;27:1160–1167
- . The effect of HER-2/neu overexpression on chemotherapeutic drug sensitivity in human breast and ovarian cancer cells. Oncogene. 1997;15:537–547
- . Ki67 expression and docetaxel efficacy in patients with estrogen receptor-positive breast cancer. J. Clin. Oncol. 2009;27:2809–2815
- . Molecular portraits of human breast tumours. Nature. 2000;406:747–752
- . Chemotherapy response of breast cancer depends on HER-status and antracycline dose intensity in the neoadjuvant setting. Clin. Cancer Res. 2001;7:1577–1581
- . Incidence, time course, and determinants of menstrual bleeding after breast cancer treatment: a prospective study. J. Clin. Oncol. 2006;24:1045–1051
- . Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N. Engl. J. Med. 2005;353:1659–1672
- . Genomic signatures to guide the use of chemotherapeutics. Nat. Med. 2006;12:1294–1300
- . Topoisomerase II-alpha gene amplification as a predictor of responsiveness to anthracycline-containing chemotherapy in the Cancer International Research Group 006 clinical trial of trastuzumqab (herceptin) in the adjuvant setting. Breast Cancer Res. Treat. 2005;94:S54;Abstr 1045
- . HER2 and responsiveness of breast cancer to adjuvant chemotherapy. N. Engl. J. Med. 2006;354:2103–2111
- . Triple-negative breast cancer: distinguishing between basal and nonbasal subtypes. Clin. Cancer Res. 2009;15:2302–2310
- . Adjuvant letrozole versus tamoxifen according to centrally-assessed ERBB2 status for postmenopausal women with endocrine-responsive early breast cancer: supplementary results from the BIG 1-98 randomised trial. Lancet Oncol. 2008;9:23–28
- . Preoperative chemotherapy: updates of national surgical adjuvant breast and bowel project protocols B-18 and B-27. J. Clin. Oncol. 2008;26:778–785
- . Breast cancer and aneusomy 17: implications for carcinogenesis and therapeutic response. Lancet Oncol. 2009;10:267–277
- . Platinum sensitivity in a BRCA1 mutation carrier with advanced breast cancer. Clin. Oncol. 2009;21:448–450
- . Oestrogen receptor status, pathological complete response and prognosis in patients receiving neoadjuvant chemotherapy for early breast cancer. Br. J. Cancer. 2004;91:2012–2017
- . Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N. Engl. J. Med. 2005;353:1673–1684
- . Targeted therapy in breast cancer: the HER-2/neu gene and protein. Mol. Cell Proteomics. 2004;3:379–398
- . High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs. Proc. Natl. Acad. Sci. U.S.A. 2008;105:17079–17084
- . Breast cancer molecular subtypes respond differently to preoperative chemotherapy. Clin. Cancer Res. 2005;11:5678–5685
- . Secondary mutations as a mechanism of cisplatin resistance in BRCA2-mutated cancers. Nature. 2008;451:1116–1119
- . An integrated approach to the prediction of chemotherapeutic response in patients with breast cancer. PLOS One. 2008;3:e1908
- . Lapatinib, a HER2 tyrosine kinase inhibitor, induces stabilization and accumulation of HER2 and potentiates trastuzumab-dependent cell cytotoxicity. Oncogene. 2009;28:803–814
- . Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution. Nature. 2009;461:809–813
- . Efficacy of neoadjuvant cisplatin in triple-negative breast cancer. J. Clin. Oncol. 2010;
- . The consensus coding sequences of human breast and colorectal cancers. Science. 2006;314:268–274
- . Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science. 1987;235:177–182
- . Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer. Science. 1989;244:707–712
- . Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N. Engl. J. Med. 2001;344:783–792
- . A phase II placebo-controlled trial of neoadjuvant anastrozole alone or with gefitinib in early breast cancer. J. Clin. Oncol. 2007;25:3816–3822
- . Breast cancer classification and prognosis based on gene expression profiles from a population-based study. Proc. Natl. Acad. Sci. U.S.A. 2003;100:10393–10398
- . Gene expression profiling in breast cancer: understanding the molecular basis of histologic grade to improve prognosis. J. Natl. Cancer Inst. 2006;98:262–272
- . Complex landscapes of somatic rearrangement in human breast cancer genomes. Nature. 2009;462:1005–1060
- . The cancer genome. Nature. 2009;458:719–724
- . The 70-gene signature as a response predictor for neoadjuvant chemotherapy in breast cancer. Breast Cancer Res. Treat. 2010;119:551–558
- . Low-dose estrogen therapy to reverse acquired antihormonal resistance in the treatment of breast cancer. Clin. Breast Cancer. 2008;8:124–133
- . Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc. Natl. Acad. Sci. U.S.A. 2001;98:10869–10874
- . Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc. Natl. Acad. Sci. U.S.A. 2003;100:8418–8423
- . Distinct molecular mechanisms underlying clinically relevant subtypes of breast cancer: gene expression analyses across three different platforms. BMC Genomics. 2006;7:
- . Triple negative breast cancer: molecular profiling and prognostic impact in adjuvant anthracycline-treated patients. Breast Cancer Res. Treat. 2008;111:27–44
- . Predictors of complete pathological response after neoadjuvant systemic therapy for breast cancer. Am. J. Surg. 2009;198:520–525
- . Topoisomerase II alpha gene amplification predicts favorable treatment response to tailored and dose-escalated anthracycline-based adjuvant chemotherapy in HER-2/neu-amplified breast cancer: Scandinavian Breast Group Trial 9401. J. Clin. Oncol. 2006;24:2428–2436
- . BRCA1 expression modulates chemosensitivity of BRCA1-defective HCC1937 human breast cancer cells. Br. J. Cancer. 2003;88:1285–1291
- . Gene expression signature predicting pathologic complete response with gemcitabine, epirubicin, and docetaxel in primary breast cancer. J. Clin. Oncol. 2006;24:1839–1845
- . Gene expression patterns associated with p53 status in breast cancer. BMC Cancer. 2006;6:
- . BRCA1 dysfunction in sporadic basal-like breast cancer. Oncogene. 2007;26:2126–2132
- . Phase II trial of the oral PARP inhibitor olaparib in BRCA-deficient advanced breast cancer. J. Clin. Oncol. (Suppl.). 2009;27(18S):803s;(CRA501)
- . Gene expression profiling predicts clinical outcome of breast cancer. Nature. 2002;415:530–536
- . A gene-expression signature as a predictor of survival in breast cancer. N. Engl. J. Med. 2002;347:1999–2009
- . Proliferation markers predictive of the pathological response and disease outcome of patients with breast carcinomas treated by anthracycline-based preoperative chemotherapy. Eur. J. Cancer. 2004;40:1502–1508
- . Assessment of histologic features and expression of biomarkers in predicting pathologic response to anthracycline-based neoadjuvant chemotherapy in patients with breast carcinoma. Cancer. 2002;94:3107–3114
- . Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. Lancet. 2005;365:671–679
- . Estrogen receptors and response of breast cancer to chemotherapy. N. Engl. J. Med. 1978;299:604–605
- . Molecular classification of breast carcinomas by comparative genomic hybridization: a specific somatic genetic profile for BRCA1 tumors. Cancer Res. 2002;62:7110–7117
- . Determination of stromal signatures in breast carcinoma. Plos Biol. 2005;3:1101–1110
- . A Phase I Study with Neratinib (HKI-272), an irreversible pan ErbB receptor tyrosine kinase inhibitor, in patients with solid tumors. Clin. Cancer Res. 2009;15:2552–2558
- . Localization of a breast-cancer susceptibility gene, Brca2, to Chromosome 13q12-13. Science. 1994;265:2088–2090
- . Suppression of HER2/HER3-Mediated growth of breast cancer cells with combinations of GDC-0941 PI3K inhibitor, trastuzumab, and pertuzumab. Clin. Cancer Res. 2009;15:4147–4156
- . Immunohistochemical expression of PTEN and phosphorylated Akt are not correlated with clinical outcome in breast cancer patients treated with trastuzumab-containing neo-adjuvant chemotherapy. Med. Oncol. 2009;26:344–349
- . The prevalence of BRCA1 mutations among young women with triple-negative breast cancer. BMC Cancer. 2009;9:
- . Mechanisms of acquired resistance to endocrine therapy in hormone-dependent breast cancer cells. J. Steroid Biochem. Mol. Biol. 2007;106:102–110
PII: S1574-7891(10)00027-X
doi: 10.1016/j.molonc.2010.04.005
© 2010 Federation of European Biochemical Societies. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
Molecular Oncology
Volume 4, Issue 3
, Pages 284-300
, June 2010

