Molecular Oncology
Volume 4, Issue 3 , Pages 230-241, June 2010

Micro-RNAs and breast cancer

Cancer Research UK, Cambridge Research Institute, Li Ka Shing Centre, Robinson Way, Cambridge CB2 0RE, UK

Received 21 January 2010; received in revised form 20 April 2010; accepted 21 April 2010. published online 10 May 2010.

Abstract 

Micro-RNAs (miRs) are a recently described class of genes, encoding small non-coding RNA molecules, which primarily act by down-regulating the translation of target mRNAs. miRs are involved in a range of normal physiological processes, notably differentiation and cell type determination. It has become apparent that they are also key factors in cancer, playing both oncogenic and tumour-suppressing roles. We discuss here what is known of miR biology in the normal breast, and of their emerging roles in breast cancer.

Keywords: Micro-RNA, Breast cancer, oncogenes, Tumor suppressors

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PII: S1574-7891(10)00031-1

doi:10.1016/j.molonc.2010.04.009

Molecular Oncology
Volume 4, Issue 3 , Pages 230-241, June 2010

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