« Previous
Next »
Molecular Oncology
Volume 4, Issue 3
, Pages 267-283
, June 2010
Tracing the tumor lineage
References
- . Is tumor growth sustained by rare cancer stem cells or dominant clones?. Cancer Res. 2008;68:4018–4021
- . Prospective identification of tumorigenic breast cancer cells. Proc. Natl. Acad. Sci. U S A. 2003;100:3983–3988
- Personalized copy number and segmental duplication maps using next-generation sequencing. Nat. Genet. 2009;41:1061–1067
- . Ductal carcinoma in situ and the emergence of diversity during breast cancer evolution. Clin. Cancer Res. 2008;14:370–378
- . Intratumoral heterogeneity in breast carcinoma revealed by laser-microdissection and comparative genomic hybridization. Cancer Genet. Cytogenet. 1999;110:94–102
- . Heterogeneity in breast cancer and the problem of relevance of findings. Anal. Cell Pathol. 1999;19:53–58
- Gene expression profiling in cervical cancer: an exploration of intratumor heterogeneity. Clin. Cancer Res. 2006;12:5632–5640
- . Chromosome 22 array-CGH profiling of breast cancer delimited minimal common regions of genomic imbalances and revealed frequent intra-tumoral genetic heterogeneity. Int. J. Oncol. 2006;29:935–945
- . Distinct patterns of DNA copy number alteration are associated with different clinicopathological features and gene-expression subtypes of breast cancer. Genes Chromosomes Cancer. 2006;45:1033–1040
- . Human cancers express a mutator phenotype. Proc. Natl. Acad. Sci. U S A. 2006;103:18238–18242
- . Mutator phenotype in cancer: timing and perspectives. Environ. Mol. Mutagen. 2005;45:206–213
- . Inferring a tumor progression model for neuroblastoma from genomic data. J. Clin. Oncol. 2005;23:7322–7331
- . CGH pattern of esthesioneuroblastoma and their metastases. Brain Pathol. 2004;14:158–163
- . Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 1997;3:730–737
- . Rudolf Carl Virchow: medical scientist, social reformer, role model. Am. J. Public Health. 2006;96:2104–2105
- Intrinsic molecular signature of breast cancer in a population-based cohort of 412 patients. Breast Cancer Res. 2006;8:R34
- . Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing. Proc. Natl. Acad. Sci. U S A. 2008;105:13081–13086
- . Breast tumor heterogeneity: cancer stem cells or clonal evolution?. Cell Cycle. 2007;6:2332–2338
- Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. JAMA. 2006;295:2492–2502
- . High-resolution mapping of copy-number alterations with massively parallel sequencing. Nat. Methods. 2009;6:99–103
- Genomic and transcriptional aberrations linked to breast cancer pathophysiologies. Cancer Cell. 2006;10:529–541
- Using array-comparative genomic hybridization to define molecular portraits of primary breast cancers. Oncogene. 2007;26:1959–1970
- . Cancer stem cells–perspectives on current status and future directions: AACR workshop on cancer stem cells. Cancer Res. 2006;66:9339–9344
- . The genetics of cancer–a 3D model. Nat. Genet. 1999;21:38–41
- . Cytogenetic and flow cytometry DNA analysis of regional heterogeneity in a low grade human glioma. Cancer Res. 1995;55:1569–1577
- Genome-wide allelic state analysis on flow-sorted tumor fractions provides an accurate measure of chromosomal aberrations. Cancer Res. 2008;68:10333–10340
- . Apocrine adenosis of the breast: clonal evidence of neoplasia. Histopathology. 2001;38:221–224
- . Die hard: are cancer stem cells the Bruce Willises of tumor biology?. Cytometry A. 2009;75:67–74
- . Clone heterogeneity in diploid and aneuploid breast carcinomas as detected by FISH. Cytometry. 2001;46:50–56
- . The origin and development of human tumors studied with cell markers. N. Engl. J. Med. 1974;291:26–35
- . Homogeneity and heterogeneity in pancreas cancer: presence of predominant and minor morphological types and implications. Int. J. Pancreatol. 1986;1:91–94
- . High-resolution array comparative genomic hybridization of single micrometastatic tumor cells. Nucleic Acids Res. 2008;36:e39
- Identification of small gains and losses in single cells after whole genome amplification on tiling oligo arrays. Nucleic Acids Res. 2009;37:e105
- . Intratumor heterogeneity of K-ras2 mutations in colorectal adenocarcinomas: association with degree of DNA aneuploidy. Am. J. Pathol. 1996;149:237–245
- . Marked intratumoral heterogeneity of c-myc and cyclinD1 but not of c-erbB2 amplification in breast cancer. Lab. Invest. 2002;82:1419–1426
- . The hallmarks of cancer. Cell. 2000;100:57–70
- In: Heim S, Mittleman F editor. Cancer Cytogenetics. third ed.. John Wiley and Sons; 2009;ISBN 10:0-470-18179-6
- . Cancer progression by non-clonal chromosome aberrations. J. Cell Biochem. 2006;98:1424–1435
- . Stochastic cancer progression driven by non-clonal chromosome aberrations. J. Cell Physiol. 2006;208:461–472
- High-resolution ROMA CGH and FISH analysis of aneuploid and diploid breast tumors. Cold Spring Harb. Symp. Quant. Biol. 2005;70:51–63
- Novel patterns of genome rearrangement and their association with survival in breast cancer. Genome Res. 2006;16:1465–1479
- . Tumor heterogeneity in lung cancer based on light microscopic features. A retrospective study of a consecutive series of 200 patients, treated surgically. Virchows Arch. A Pathol. Anat. Histopathol. 1983;402:147–153
- . Multivariate analysis of chromosomal imbalances in breast cancer delineates cytogenetic pathways and reveals complex relationships among imbalances. Cancer Res. 2002;62:2675–2680
- . Statistical behavior of complex cancer karyotypes. Genes Chromosomes Cancer. 2005;42:327–341
- . Genetic alterations in primary bladder cancers and their metastases. Cancer Res. 1998;58:3555–3560
- The molecular portraits of breast tumors are conserved across microarray platforms. BMC Genomics. 2006;7:96
- . Understanding the molecular basis of histologic grade. Pathobiology. 2008;75:104–111
- . Genomic instability of micronucleated cells revealed by single-cell comparative genomic hybridization. Cytometry A. 2009;75:562–568
- . Genomic analyses of primary and metastatic serous epithelial ovarian cancer. Cancer Genet. Cytogenet. 2004;154:16–21
- . Genetic changes and clonality relationship between primary colorectal cancers and their pulmonary metastases–an analysis by comparative genomic hybridization. Genes Chromosomes Cancer. 2005;43:25–36
- . Approaching solid tumor heterogeneity on a cellular basis by tissue proteomics using laser capture microdissection and biological mass spectrometry. J. Proteome Res. 2009;8:2310–2318
- . Comparison of fresh and paraffin-embedded tissue as starting material for DNA flow cytometry and evaluation of intratumor heterogeneity. Cytometry. 1988;9:164–169
- . Genetic intra-tumour heterogeneity in epithelial ovarian cancer and its implications for molecular diagnosis of tumours. J. Pathol. 2007;211:286–295
- . Tumor self-seeding by circulating cancer cells. Cell. 2009;139:1315–1326
- . Comparative genomic hybridization, loss of heterozygosity, and DNA sequence analysis of single cells. Proc. Natl. Acad. Sci. U S A. 1999;96:4494–4499
- . Problems in histological grading of malignancy and its clinical significance in patients with operable breast cancer. Breast Cancer. 2006;13:249–253
- . Prognostic significance of a grading system considering tumor heterogeneity in muscle-invasive urothelial carcinoma of the urinary bladder. Int. Urol. Nephrol. 2003;35:169–173
- . Genomic instability in breast cancer: Pathogenesis and clinical implications. Mol. Oncol. 2010;4(3):255–266
- . A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature. 1994;367:645–648
- Single-cell chromosomal imbalances detection by array CGH. Nucleic Acids Res. 2006;34:e68
- . Identification of pancreatic cancer stem cells. Cancer Res. 2007;67:1030–1037
- . Glucose-6-phosphate dehydrogenase mosaicism: utilization as a cell marker in the study of leiomyomas. Science. 1965;150:67–69
- Progression and tumor heterogeneity analysis in early rectal cancer. Clin. Cancer Res. 2008;14:772–781
- . Inferring progression models for CGH data. Bioinformatics. 2009;25:2208–2215
- Copy number analysis indicates monoclonal origin of lethal metastatic prostate cancer. Nat. Med. 2009;15:559–565
- . Errors in DNA replication as a basis of malignant changes. Cancer Res. 1974;34:2311–2321
- Genetic clonal diversity predicts progression to esophageal adenocarcinoma. Nat. Genet. 2006;38:468–473
- . Tumor heterogeneity: causes and consequences. Biochim. Biophys. Acta. 2009;
- . Loss of heterozygosity analysis shows monoclonal evolution with frequent genetic progression and divergence in esophageal carcinosarcoma. Hum. Pathol. 2004;35:322–327
- . Clinical significance of cytogenetic findings in solid tumors. Cancer Genet. Cytogenet. 1997;95:1–8
- . Genetic heterogeneity and clonal evolution in neuroblastoma. Br. J. Cancer. 2001;85:182–189
- Inferring tumor progression from genomic heterogeneity. Genome Res. 2010;20:68–80
- . Clonal analysis of human breast cancer by means of the polymerase chain reaction. Cancer Res. 1992;52:6594–6597
- . Clonal analysis of predominantly intraductal carcinoma and precancerous lesions of the breast by means of polymerase chain reaction. Cancer Res. 1994;54:1849–1853
- . Cancer stem cells, self-seeding, and decremented exponential growth: theoretical and clinical implications. Breast Dis. 2008;29:27–36
- . Is cancer a disease of self-seeding?. Nat. Med. 2006;12:875–878
- . The clonal evolution of tumor cell populations. Science. 1976;194:23–28
- . A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature. 2007;445:106–110
- . The distribution of secondary growths in cancer of the breast. Lancet. 1889;133:571–573
- Chromosome analysis of 97 primary breast carcinomas: identification of eight karyotypic subgroups. Genes Chromosomes Cancer. 1995;12:173–185
- . Cytogenetic manifestations of multiple myeloma heterogeneity. Genes Chromosomes Cancer. 2005;42:44–57
- . Construction of oncogenetic tree models reveals multiple pathways of oral cancer progression. Int. J. Cancer. 2009;124:2864–2871
- Molecular portraits of human breast tumours. Nature. 2000;406:747–752
- Triple-negative breast cancer: Present challenges and new perspectives.. Mol. Oncol. 2010;4(3):209–229
- . Breast cancer stem cells: a case of mistaken identity?. Stem Cell Rev. 2007;3:107–109
- . Breast cancer: origins and evolution. J. Clin. Invest. 2007;117:3155–3163
- . Efficient tumour formation by single human melanoma cells. Nature. 2008;456:593–598
- . Basal-like breast cancer: a critical review. J. Clin. Oncol. 2008;26:2568–2581
- . Aneuploidy of chromosome 8 as detected by interphase fluorescence in situ hybridization is a recurrent finding in primary and metastatic breast cancer. Breast Cancer Res. Treat. 1998;48:125–133
- . Heterogeneity of chromosome 17 and erbB-2 gene copy number in primary and metastatic bladder cancer. Cytometry. 1995;21:40–46
- . Clonal analysis of human gynecologic cancers by means of the polymerase chain reaction. Int. J. Cancer. 1994;58:492–496
- . Genomic signatures of chromosomal instability and osteosarcoma progression detected by high resolution array CGH and interphase FISH. Cytogenet. Genome Res. 2008;122:5–15
- . Heterogeneity in cancer: cancer stem cells versus clonal evolution. Cell. 2009;138:822–829
- Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution. Nature. 2009;461:809–813
- Molecular definition of breast tumor heterogeneity. Cancer Cell. 2007;11:259–273
- . The cancer stem cell hypothesis: in search of definitions, markers, and relevance. Lab. Invest. 2008;88:459–463
- . Identification of human brain tumour initiating cells. Nature. 2004;432:396–401
- Gene expression patterns of carcinomas distinguish tumor subclasses with clinical implications. Proc. Natl. Acad. Sci. U S A. 2001;98:10869–10874
- Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc. Natl. Acad. Sci. U S A. 2003;100:8418–8423
- . Cytogenetic analysis of multifocal breast carcinomas: detection of karyotypically unrelated clones as well as clonal similarities between tumour foci. Br. J. Cancer. 1994;70:922–927
- . Clonal heterogeneity in breast cancer: karyotypic comparisons of multiple intra- and extra-tumorous samples from 3 patients. Int. J. Cancer. 1995;63:63–68
- . Karyotypic comparisons of multiple tumorous and macroscopically normal surrounding tissue samples from patients with breast cancer. Cancer Res. 1996;56:855–859
- . Intratumor genomic heterogeneity in breast cancer with clonal divergence between primary carcinomas and lymph node metastases. Breast Cancer Res. Treat. 2007;102:143–155
- . Cytogenetic and molecular biologic alterations in human breast cancer: a review. Breast Cancer Res. Treat. 1985;5:221–229
- . Karyotypic evolution in breast carcinomas with i(1)(q10) and der(1;16)(q10;p10) as the primary chromosome abnormality. Cancer Genet. Cytogenet. 1999;113:156–161
- . Intratumoral nuclear morphologic heterogeneity in prostate cancer. Urology. 1997;49:652–657
- . Inferring trees. Methods Mol. Biol. 2008;452:287–309
- Chromosomal imbalances in primary and metastatic pancreatic carcinoma as detected by interphase cytogenetics: basic findings and clinical aspects. Br. J. Cancer. 1998;77:1337–1342
PII: S1574-7891(10)00032-3
doi: 10.1016/j.molonc.2010.04.010
« Previous
Next »
Molecular Oncology
Volume 4, Issue 3
, Pages 267-283
, June 2010

