Molecular Oncology
Volume 4, Issue 4 , Pages 347-356 , August 2010

Cox-2 gene expression in chemically induced skin papillomas cannot predict subsequent tumor fate

  • Tomo-o Ishikawa

      Affiliations

    • Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
    • ,
  • Naveen K. Jain

      Affiliations

    • Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
    • ,
  • Harvey R. Herschman

      Affiliations

    • Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
    • Department of Biological Chemistry, David Geffen School of Medicine, UCLA, Los Angeles, CA, USA
    • Molecular Biology Institute, UCLA, Los Angeles, CA, USA
    • Corresponding Author InformationCorresponding author at: 341 Boyer Hall, UCLA, 611 Charles E. Young Drive East, Los Angeles, CA 90095, USA. Tel.: +1 310 825 8735; fax: +1 310 825 1447.

Received 27 February 2010 ,Revised 9 June 2010 ,Accepted 9 June 2010.

References 

  1. An KP, Athar M, Tang X, Katiyar SK, Russo J, Beech J, et al Cyclooxygenase-2 expression in murine and human nonmelanoma skin cancers: implications for therapeutic approaches. Photochem. Photobiol. 2002;76(1):73–80
  2. Brecher AR. The role of cyclooxygenase-2 in the pathogenesis of skin cancer. J. Drugs Dermatol. 2002;1(1):44–47
  3. Collaco AM, Geusz ME. Monitoring immediate-early gene expression through firefly luciferase imaging of HRS/J hairless mice. BMC Physiol. 2003;3:8
  4. Fischer SM, Furstenberger G, Marks F, Slaga TJ. Events associated with mouse skin tumor promotion with respect to arachidonic acid metabolism: a comparison between SENCAR and NMRI mice. Cancer Res. 1987;47(12):3174–3179
  5. Fischer SM, Lo HH, Gordon GB, Seibert K, Kelloff G, Lubet RA, et al. Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, and indomethacin against ultraviolet light-induced skin carcinogenesis. Mol. Carcinog. 1999;25(4):231–240
  6. Fischer SM, Pavone A, Mikulec C, Langenbach R, Rundhaug JE. Cyclooxygenase-2 expression is critical for chronic UV-induced murine skin carcinogenesis. Mol. Carcinog. 2007;46(5):363–371
  7. Hennings H, Glick AB, Lowry DT, Krsmanovic LS, Sly LM, Yuspa SH. FVB/N mice: an inbred strain sensitive to the chemical induction of squamous cell carcinomas in the skin. Carcinogenesis. 1993;14(11):2353–2358
  8. Howe LR, Dannenberg AJ. A role for cyclooxygenase-2 inhibitors in the prevention and treatment of cancer. Semin. Oncol. 2002;29(3 Suppl. 11):111–119
  9. Ishikawa T, Jain NK, Taketo MM, Herschman HR. Imaging cyclooxygenase-2 (Cox-2) gene expression in living animals with a luciferase knock-in reporter gene. Mol. Imaging Biol. 2006;8(3):171–187
  10. Ishikawa T, Jain N, Herschman HR. Feedback regulation of cyclooxygenase-2 transcription ex vivo and in vivo. Biochem. Biophys. Res. Commun. 2009;378(3):534–538
  11. Ishikawa T, Kumar JP, Machado HB, Wong K, Kusewitt D, Huang S, et al. Positron emission tomography imaging of DMBA/TPA mouse skin multi-step tumorigenesis. Mol. Oncol. 2010;4(2):119–125
  12. Johnson TW, Anderson KE, Lazovich D, Folsom AR. Association of aspirin and nonsteroidal anti-inflammatory drug use with breast cancer. Cancer Epidemiol. Biomarkers Prev. 2002;11(12):1586–1591
  13. Kemp CJ. Multistep skin cancer in mice as a model to study the evolution of cancer cells. Semin. Cancer Biol. 2005;15(6):460–473
  14. Marks F, Furstenberger G, Muller-Decker K. Arachidonic acid metabolism as a reporter of skin irritancy and target of cancer chemoprevention. Toxicol. Lett. 1998;96–97:111–118
  15. McCawley LJ, Wright J, LaFleur BJ, Crawford HC, Matrisian LM. Keratinocyte expression of MMP3 enhances differentiation and prevents tumor establishment. Am. J. Pathol. 2008;173(5):1528–1539
  16. Muller-Decker K, Kopp-Schneider A, Marks F, Seibert K, Furstenberger G. Localization of prostaglandin H synthase isoenzymes in murine epidermal tumors: suppression of skin tumor promotion by inhibition of prostaglandin H synthase-2. Mol. Carcinog. 1998;23(1):36–44
  17. Muller-Decker K, Reinerth G, Krieg P, Zimmermann R, Heise H, Bayerl C, et al. Prostaglandin-H-synthase isozyme expression in normal and neoplastic human skin. Int. J. Cancer. 1999;82(5):648–656
  18. Muller-Decker K, Scholz K, Marks F, Furstenberger G. Differential expression of prostaglandin H synthase isozymes during multistage carcinogenesis in mouse epidermis. Mol. Carcinog. 1995;12(1):31–41
  19. Oshima M, Dinchuck JE, Kargman SL, Oshima H, Hancock B, Kwong E, et al. Suppression of intestinal polyposis in ApcD716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell. 1996;87:803–809
  20. Quintanilla M, Brown K, Ramsden M, Balmain A. Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis. Nature. 1986;322(6074):78–80
  21. Rauch D, Gross S, Harding J, Niewiesk S, Lairmore M, Piwnica-Worms D, et al. Imaging spontaneous tumorigenesis: inflammation precedes development of peripheral NK tumors. Blood. 2009;113(7):1493–1500
  22. Scholz K, Furstenberger G, Muller-Decker K, Marks F. Differential expression of prostaglandin-H synthase isoenzymes in normal and activated keratinocytes in vivo and in vitro. Biochem. J. 1995;309(Pt 1):263–269
  23. Smalley WE, DuBois RN. Colorectal cancer and nonsteroidal anti-inflammatory drugs. Adv. Pharmacol. 1997;39:1–20
  24. Steinbach G, Lynch PM, Phillips RK, Wallace MH, Hawk E, Gordon GB, et al The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis. N. Engl. J. Med. 2000;342(26):1946–1952
  25. Subbaramaiah K, Dannenberg AJ. Cyclooxygenase 2: a molecular target for cancer prevention and treatment. Trends Pharmacol. Sci. 2003;24(2):96–102
  26. Tiano HF, Loftin CD, Akunda J, Lee CA, Spalding J, Sessoms A, et al Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis. Cancer Res. 2002;62(12):3395–3401

PII: S1574-7891(10)00050-5

doi: 10.1016/j.molonc.2010.06.004

Molecular Oncology
Volume 4, Issue 4 , Pages 347-356 , August 2010

Article Tools

* Image Usage & Resolution