« Previous
Next »
Molecular Oncology
Volume 4, Issue 5
, Pages 404-419
, October 2010
Targeting breast cancer stem cells
References
- . Randomised phase III study of intravenous vinorelbine plus hormone therapy versus hormone therapy alone in hormone-refractory prostate cancer. Ann. Oncol. 2004;15:1613–1621
- . In vivo effects of imatinib mesylate on human haematopoietic progenitor cells. Eur. J. Clin. Invest. 2006;36:402–408
- . Prospective identification of tumorigenic breast cancer cells. Proc. Natl. Acad. Sci. USA. 2003;100:3983–3988
- . Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature. 2006;444:756–760
- . MicroRNAs: target recognition and regulatory functions. Cell. 2009;136:215–233
- . Fluorescence activated cell sorting. Rev. Sci. Instrum. 1972;43:404–409
- . Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat. Med. 1997;3:730–737
- . Prospects for productivity. Nat. Rev. Drug Discov. 2004;3:451–456
- . Notch signaling regulates mammary stem cell function and luminal cell-fate commitment. Cell Stem Cell. 2008;3:429–441
- . Opinion: migrating cancer stem cells – an integrated concept of malignant tumour progression. Nat. Rev. Cancer. 2005;5:744–749
- . A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial–mesenchymal transition. Cancer Res. 2008;68:7846–7854
- . Notch signalling: a simple pathway becomes complex. Nat. Rev. Mol. Cell Biol. 2006;7:678–689
- . Drug target identification using side-effect similarity. Science. 2008;321:263–266
- . Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature. Cancer Res. 2009;69:1302–1313
- . New therapies from old medicines. Nat. Biotechnol. 2008;26:1077–1083
- . Isolation and molecular characterization of cancer stem cells in MMTV-Wnt-1 murine breast tumors. Stem Cells. 2008;26:364–371
- . New uses for old drugs. Nature. 2007;448:645–646
- . Median absolute deviation to improve hit selection for genome-scale RNAi screens. J. Biomol. Screen. 2008;13:149–158
- . The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells. Cell. 2009;138:1083–1095
- . Cancer stem cells–perspectives on current status and future directions: AACR workshop on cancer stem cells. Cancer Res. 2006;66:9339–9344
- . Regulation of human breast epithelial stem cells. Cell Prolif. 2003;36(Suppl. 1):45–58
- . A putative human breast stem cell population is enriched for steroid receptor-positive cells. Dev. Biol. 2005;277:443–456
- . Studies of cellular proliferation in human leukemia. 3. Behavior of leukemic cells in three adults with acute leukemia given continuous infusions of 3H-thymidine for 8 or 10 days. Cancer. 1970;25:1237–1260
- . Review of recent studies of cellular proliferation in acute leukemia. Natl. Cancer Inst. Monogr. 1969;30:81–120
- . Changing concepts of treatment in acute leukemia. Med. Clin. North Am. 1971;55:561–600
- . Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes Dev. 2003;17:3029–3035
- . Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features. Proc. Natl. Acad. Sci. USA. 2009;106:13820–13825
- . The in vivo life span of normal and preneoplastic mouse mammary glands: a serial transplantation study. Proc. Natl. Acad. Sci. USA. 1968;61:53–60
- . Influence of cell division on an aging process. Life span of mouse mammary epithelium during serial propagation in vivo. Exp. Cell Res. 1971;65:27–32
- . Myelotoxicity from chemotherapy. Semin. Oncol. 2006;33:74–85
- . Regeneration of intestinal stem/progenitor cells following doxorubicin treatment of mice. Am. J. Physiol. Gastrointest. Liver Physiol. 2009;297:G461–G470
- . Loss of heterozygosity in normal tissue adjacent to breast carcinomas. Science. 1996;274:2057–2059
- . Development of mammary tumors from hyperplastic alveolar nodules transplanted into gland-free mammary fat pads of female C3H. J. Natl. Cancer Inst. 1959;78:751–757
- . Chemical genetics reveals a complex functional ground state of neural stem cells. Nat. Chem. Biol. 2007;3:268–273
- . Stem cells: self-renewal writ in blood. Nature. 2003;423:231–233
- . Stem cell concepts renew cancer research. Blood. 2008;112:4793–4807
- . Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation. Cancer Cell. 2008;14:238–249
- . In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev. 2003;17:1253–1270
- . Role of notch signaling in cell-fate determination of human mammary stem/progenitor cells. Breast Cancer Res. 2004;6:R605–R615
- . Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells. Blood. 2009;114:3064–3073
- . A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability. Nat. Med. 2008;14:1384–1389
- . New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur. J. Cancer. 2009;45:228–247
- . PTEN: one gene, many syndromes. Hum. Mutat. 2003;22:183–198
- . Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 1998;391:806–811
- . Salinomycin induces apoptosis and overcomes apoptosis resistance in human cancer cells. Biochem. Biophys. Res. Commun. 2009;390:743–749
- . The transmission of leukemia of mice with a single cell. Am. J. Cancer. 1937;31:276–282
- . ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell. 2007;1:555–567
- . CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts. J. Clin. Invest. 2010;
- . Getting to the root of BRCA1-deficient breast cancer. Cell Stem Cell. 2009;5:229–230
- . Spindle orientation, asymmetric division and tumour suppression in Drosophila stem cells. Nat. Rev. Genet. 2007;8:462–472
- . A putative role for microRNA-205 in mammary epithelial cell progenitors. J. Cell Sci. 2010;
- . The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat. Cell Biol. 2008;10:593–601
- . miRBase: tools for microRNA genomics. Nucleic Acids Res. 2008;36:D154–D158
- . Super target and matador: resources for exploring drug–target relationships. Nucleic Acids Res. 2008;36:D919–D922
- . Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation. Nature. 2008;453:529–533
- . Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell. 2009;138:645–659
- . Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells. Blood. 2001;98:2301–2307
- . The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells. Blood. 2005;105:4163–4169
- . An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells. Blood. 2007;110:4427–4435
- . Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor. Cancer Res. 2010;70:709–718
- . Discovery of agents that eradicate leukemia stem cells using an in silico screen of public gene expression data. Blood. 2008;111:5654–5662
- . The functional loss of the retinoblastoma tumour suppressor is a common event in basal-like and luminal B breast carcinomas. Breast Cancer Res. 2008;10:R75
- . Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol. 2007;8:R76
- . PTEN, stem cells, and cancer stem cells. J. Biol. Chem. 2009;284:11755–11759
- . p53 mutations in human cancers. Science. 1991;253:49–53
- . Acute myeloid leukemia originates from a hierarchy of leukemic stem cell classes that differ in self-renewal capacity. Nat. Immunol. 2004;5:738–743
- . The paradox of response and survival in cancer therapeutics. Blood. 2006;107:431–434
- . MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors. Cancer Cell. 2004;6:587–596
- . Response of intestinal cells of differing topographical and hierarchical status to ten cytotoxic drugs and five sources of radiation. Br. J. Cancer. 1983;47:175–185
- . Further studies on the response of intestinal crypt cells of different hierarchical status to eighteen different cytotoxic agents. Br. J. Cancer. 1987;55:113–123
- . Utilizing RNA interference to enhance cancer drug discovery. Nat. Rev. Drug Discov. 2007;6:556–568
- . Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application. Nat. Rev. Drug Discov. 2010;9:57–67
- Jeselsohn, R., Brown, N.E., Arendt, L., Klebba, I., Hu, M.G., Kuperwasser, C., Hinds, P.W., 2010. Cyclin D1 kinase activity is required for the self-renewal of mammary stem and progenitor cells that are targets of MMTV-ErbB2 tumorigenesis 17, 65–76.
- . Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands. Genes Dev. 1992;6:345–355
- . Hedgehog signaling in development and cancer. Dev. Cell. 2008;15:801–812
- . Targeting of CD44 eradicates human acute myeloid leukemic stem cells. Nat. Med. 2006;12:1167–1174
- . Monoclonal antibody-mediated targeting of CD123, IL-3 receptor alpha chain, eliminates human acute myeloid leukemic stem cells. Cell Stem Cell. 2009;5:31–42
- . Predicting new molecular targets for known drugs. Nature. 2009;462:175–181
- . Tumor growth need not be driven by rare cancer stem cells. Science. 2007;317:337
- . The role of PTEN signaling perturbations in cancer and in targeted therapy. Oncogene. 2008;27:5477–5485
- . Comment on “Tumor growth need not be driven by rare cancer stem cells”. Science. 2007;318:1722;author reply 1722
- . An entire functional mammary gland may comprise the progeny from a single cell. Development. 1998;125:1921–1930
- . Regulation of mammary stem/progenitor cells by PTEN/Akt/beta-catenin signaling. PLoS Biol. 2009;7:e1000121
- . Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature. 2006;442:818–822
- . Fluorescent cell barcoding in flow cytometry allows high-throughput drug screening and signaling profiling. Nat. Methods. 2006;3:361–368
- . Reconstruction of functionally normal and malignant human breast tissues in mice. Proc. Natl. Acad. Sci. USA. 2004;101:4966–4971Epub 2004 Mar 4929
- . The connectivity map: using gene-expression signatures to connect small molecules, genes, and disease. Science. 2006;313:1929–1935
- . Breast cancer incidence among atomic bomb survivors: implications for radiobiologic risk at low doses. J. Natl. Cancer Inst. 1979;62:17–21
- . A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature. 1994;367:645–648
- . Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature. 2003;423:255–260
- . Identification of pancreatic cancer stem cells. Cancer Res. 2007;67:1030–1037
- . Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland. Development. 2002;129:4159–4170
- . Intrinsic resistance of tumorigenic breast cancer cells to chemotherapy. J. Natl. Cancer Inst. 2008;100:672–679
- . Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proc. Natl. Acad. Sci. USA. 2003;100:15853–15858
- . Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers. Nat. Med. 2009;15:907–913
- . The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells. Proc. Natl. Acad. Sci. USA. 2004;101:4158–4163
- . Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Cancer Res. 2006;66:6063–6071
- . BRCA1 regulates human mammary stem/progenitor cell fate. Proc. Natl. Acad. Sci. USA. 2008;105:1680–1685
- . CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell. 2009;138:286–299
- . Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood. Cell Stem Cell. 2007;1:635–645
- . The epithelial–mesenchymal transition generates cells with properties of stem cells. Cell. 2008;133:704–715
- . The radiation sensitivity of normal mouse bone marrow cells, determined by quantitative marrow transplantation into irradiated mice. Radiat. Res. 1960;13:115
- . Individual stem cells with highly variable proliferation and self-renewal properties comprise the human hematopoietic stem cell compartment. Nat. Immunol. 2006;7:1225–1233
- . Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature. 2003;425:962–967
- . Application of massively parallel sequencing to microRNA profiling and discovery in human embryonic stem cells. Genome Res. 2008;18:610–621
- . Asymmetric and symmetric stem-cell divisions in development and cancer. Nature. 2006;441:1068–1074
- . Lessons from 60 years of pharmaceutical innovation. Nat. Rev. Drug Discov. 2009;8:959–968
- . Characterization of Dicer-deficient murine embryonic stem cells. Proc. Natl. Acad. Sci. USA. 2005;102:12135–12140
- . Dividing cellular asymmetry: asymmetric cell division and its implications for stem cells and cancer. Genes Dev. 2009;23:2675–2699
- . Managing hematologic toxicities: novel therapies. Cancer Nurs. 2003;26:32S–37S
- . Differentiation therapy of leukemia: 3 decades of development. Blood. 2009;113:3655–3665
- . A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature. 2007;445:106–110
- . How many drug targets are there?. Nat. Rev. Drug Discov. 2006;5:993
- . Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature. 2003;423:302–305
- . The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev. 2008;22:894–907
- . Molecular portraits of human breast tumours. Nature. 2000;406:747–752
- . Drug-target identification in Drosophila cells: combining high-throughout RNAi and small-molecule screens. Drug Discov. Today. 2007;12:28–33
- . Regulating cancer stem cells the miR way. Cell Stem Cell. 2010;6:4–6
- . The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiation. J. Natl. Cancer Inst. 2006;98:1777–1785
- . Teratocarcinogenic and tissue-forming potentials of the cell types comprising neoplastic embryoid bodies. Lab. Invest. 1960;9:583–602
- . Tumors as caricatures of the process of tissue renewal: prospects for therapy by directing differentiation. Cancer Res. 1988;48:1996–2004
- . Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens. Cell Stem Cell. 2009;4:568–580
- . Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc. Natl. Acad. Sci. USA. 2007;
- . Efficient tumour formation by single human melanoma cells. Nature. 2008;456:593–598
- . Sensing radiosensitivity of human epidermal stem cells. Radiother. Oncol. 2007;83:267–276
- . Stem cells, cancer, and cancer stem cells. Nature. 2001;414:105–111
- . Target profiling of small molecules by chemical proteomics. Nat. Chem. Biol. 2009;5:616–624
- . Irinotecan plus gemcitabine results in no survival advantage compared with gemcitabine monotherapy in patients with locally advanced or metastatic pancreatic cancer despite increased tumor response rate. J. Clin. Oncol. 2004;22:3776–3783
- Roesch, A., Fukunaga-Kalabis, M., Schmidt, E.C., Zabierowski, S.E., Brafford, P.A., Vultur, A., Basu, D., Gimotty, P., Vogt, T., Herlyn, M., 2010. A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth. 141, 583–594.
- . Targeting the Hedgehog pathway in cancer. Nat. Rev. Drug Discov. 2006;5:1026
- . Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N. Engl. J. Med. 2009;361:1173–1178
- . IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland. J. Clin. Invest. 2007;117:3988–4002
- . Generation of a functional mammary gland from a single stem cell. Nature. 2006;439:84–88
- . Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell. 2009;138:592–603
- . The cancer stem cell hypothesis: in search of definitions, markers, and relevance. Lab. Invest. 2008;88:459–463
- . Humanized mice in translational biomedical research. Nat. Rev. Immunol. 2007;7:118–130
- . Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice. J. Immunol. 1995;154:180–191
- . Identification of human brain tumour initiating cells. Nature. 2004;432:396–401
- . A morphologically distinct candidate for an epithelial stem cell in mouse mammary gland. J. Cell Sci. 1988;90:173–183
- . Identification and characterization of leukemia stem cells in murine MLL-AF9 acute myeloid leukemia. Cancer Cell. 2006;10:257–268
- . Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc. Natl. Acad. Sci. USA. 2001;98:10869–10874
- . Autologous and Homologous Transplantation of Human Cancer. Biological Interactions in Normal and Neoplastic Growth: a Contribution to the Tumor-Host Problem. Boston, MA: Little Brown; 1962;pp. 723–738
- . Purification and characterization of mouse hematopoietic stem cells. Science. 1988;241:58–62(erratum appears in Science 1989 Jun 2. 244(4908), 1030)
- . Purification and unique properties of mammary epithelial stem cells. Nature. 2006;439:993–997
- . Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature. 2003;425:851–856
- . Paracrine hedgehog signaling in cancer. Cancer Res. 2009;69:6007–6010
- . Gene expression patterns associated with p53 status in breast cancer. BMC Cancer. 2006;6:276
- . CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment. Semin. Radiat. Oncol. 2003;13:176–181
- . Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration. Proc. Natl. Acad. Sci. USA. 2006;103:14134–14139
- . Contiguous patches of normal human mammary epithelium derived from a single stem cell: implications for breast carcinogenesis. Cancer Res. 1996;56:402–404
- . The mammary progenitor marker CD61/beta3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis. Cancer Res. 2008;68:7711–7717
- . Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis. Genes Dev. 2009;23:2563–2577
- . Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N. Engl. J. Med. 2009;361:1164–1172
- . Notch promotes radioresistance of glioma stem cells. Stem Cells. 2010;28:17–28
- . Evaluating therapeutic efficacy against cancer stem cells: new challenges posed by a new paradigm. Cell Stem Cell. 2007;1:497–501
- . Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation. Proc. Natl. Acad. Sci. USA. 2006;103:1480–1485
- . Embryonic stem cell-specific microRNAs regulate the G1-S transition and promote rapid proliferation. Nat. Genet. 2008;40:1478–1483
- . Total body irradiation selectively induces murine hematopoietic stem cell senescence. Blood. 2006;107:358–366
- . Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature. 2003;422:313–317
- . Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance. Cancer Cell. 2006;10:331–342
- . The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat. Cell Biol. 2009;11:1487–1495
- . Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science. 2004;306:269–271
- . Knocking down barriers: advances in siRNA delivery. Nat. Rev. Drug Discov. 2009;8:129–138
- . Synthetic lethal screen identification of chemosensitizer loci in cancer cells. Nature. 2007;446:815–819
- . DrugBank: a knowledgebase for drugs, drug actions and drug targets. Nucleic Acids Res. 2008;36:D901–D906
- . WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells. Proc. Natl. Acad. Sci. USA. 2007;104:618–623
- . An RNAi screen identifies TRRAP as a regulator of brain tumor-initiating cell differentiation. Cell Stem Cell. 2010;6:37–47
- . MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell. 2009;137:647–658
- . Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature. 2006;441:475–482
- . The influence of host and tissue age on life span and growth rate of serially transplanted mouse mammary gland. Exp. Gerontol. 1971;6:49–56
- . let-7 regulates self renewal and tumorigenicity of breast cancer cells. Cell. 2007;131:1109–1123
- . PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention. Nature. 2006;441:518–522
- . Identification of tumor-initiating cells in a p53-null mouse model of breast cancer. Cancer Res. 2008;68:4674–4682
PII: S1574-7891(10)00051-7
doi: 10.1016/j.molonc.2010.06.005
© 2010 Federation of European Biochemical Societies. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
Molecular Oncology
Volume 4, Issue 5
, Pages 404-419
, October 2010

