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Introduction
Molecular Oncology is an international comprehensive journal that publishes original research,
editorial commentaries, review articles and news on molecular oncology. It highlights new discoveries, approaches, as well as technical
developments, in basic, clinical and discovery-driven translational cancer research.
The emphasis is on work that significantly advances
our understanding of disease processes leading to human tumour development and/or establishes novel concepts of clear clinical significance
in diagnosis, prognosis and prevention strategies for cancer patients.
Topics include, but are not limited to:
- Key
biological processes such as cell cycle; DNA repair; apoptosis; invasion and metastasis; angiogenesis and lymphangiogenesis; cell signalling
and interactive networks; immune response.
- Emerging technologies (genomics, proteomics, functional genomics, metabolomics,
tissue arrays, bio-imaging), and model systems.
- Biomarkers: diagnosis, prognosis, stratification and efficacy.
-
Cancer genetics, epigenetics, and genomic instability.
- Minimal residual disease, pre-malignant lesions.
- Cancer
micro-environment.
- Molecular pathology.
- Tumour immunology.
- Translational research.
- Cancer
therapy (target discovery, drug design, immunotherapy, combination therapies, resistance, and individualised treatment).
-
Chemotherapy, radiotherapy and surgery.
- Clinical pharmacology.
- Clinical trials, integration of basic science
into cancer clinical trials. Epidemiology.
- Infrastructures (biobanks, databases, genomic resources, technology platforms).
A main feature of the Journal is to provide an international Forum for debating cancer issues, and
for integrating the input of all the stakeholders.
Types of paper
Full-length
research articles, Technical Notes, News and Views, Reviews and Mini-Reviews, Letters to the Editor.
Contact details for submission
Papers should be submitted using the Molecular Oncology online
submission system,  http://ees.elsevier.com/molonc. For questions on the submission or reviewing process, please contact
the Editorial Office prior to submission at e-mail: molonc@cancer.dk
Page
charges
This journal has no page charges.
Ethics in Publishing
For information on Ethics in Publishing and Ethical guidelines for journal publication
see http://www.elsevier.com/publishingethics and http://www.elsevier.com/ethicalguidelines.
Policy and ethics
The work described in your article must have been carried out in accordance with The
Code of Ethics of the World Medical Association (Declaration of Helsinki) for experiments involving humans http://www.wma.net/e/policy/b3.htm; EC Directive 86/609/EEC for animal experiments http://ec.europa.eu/environment/chemicals/lab_animals/legislation_en.htm; Uniform Requirements for manuscripts submitted to Biomedical journals http://www.icmje.org. This must be stated
at an appropriate point in the article.
Conflict of interest
All authors
are requested to disclose any actual or potential conflict of interest including any financial, personal or other relationships with
other people or organizations within three years of beginning the submitted work that could inappropriately influence, or be perceived
to influence, their work. See also http://www.elsevier.com/conflictsofinterest.
Submission declaration
Submission of an article implies that the work described has not been published previously (except
in the form of an abstract or as part of a published lecture or academic thesis), that it is not under consideration for publication
elsewhere, that its publication is approved by all authors and tacitly or explicitly by the responsible authorities where the work was
carried out, and that, if accepted, it will not be published elsewhere including electronically in the same form, in English or in any
other language, without the written consent of the copyright-holder.
Authorship
All authors should have made substantial contributions to all of the following: (1) the conception and design of the study, or
acquisition of data, or analysis and interpretation of data, (2) drafting the article or revising it critically for important intellectual
content, (3) final approval of the version to be submitted.
Copyright
Upon
acceptance of an article, authors will be asked to complete a 'Journal Publishing Agreement' (for more information on this and copyright
see http://www.elsevier.com/copyright). Acceptance of the agreement will ensure the widest possible dissemination of information.
An e-mail will be sent to the corresponding author confirming receipt of the manuscript together with a 'Journal Publishing Agreement'
form or a link to the online version of this agreement.
Subscribers may reproduce tables of contents or prepare lists of articles
including abstracts for internal circulation within their institutions. Permission of the Publisher is required for resale or distribution
outside the institution and for all other derivative works, including compilations and translations (please consult http://www.elsevier.com/permissions).
If excerpts from other copyrighted works are included, the author(s) must obtain written permission from the copyright owners and credit
the source(s) in the article. Elsevier has preprinted forms for use by authors in these cases: please consult http://www.elsevier.com/permissions.
Retained author rights
As an author you (or your employer or institution) retain certain rights; for details
you are referred to: http://www.elsevier.com/authorsrights.
Role of the
funding source
You are requested to identify who provided financial support for the conduct of the research and/or preparation
of the article and to briefly describe the role of the sponsor(s), if any, in study design; in the collection, analysis and interpretation
of data; in the writing of the report; and in the decision to submit the paper for publication. If the funding source(s) had no such
involvement then this should be stated. Please see http://www.elsevier.com/funding.
Funding body agreements and policies
Elsevier journals comply with current NIH public access policy
Sponsored articles
This journal offers authors the option to sponsor non-subscriber access to their articles
on Elsevier's electronic publishing platforms. For more information please view our Sponsored Articles page at http://www.elsevier.com/sponsoredarticles.
Language and language services
Please write your text in good English (American or British usage is accepted,
but not a mixture of these). Authors who require information about language editing and copyediting services pre- and post-submission
please visit http://www.elsevier.com/languageediting or our customer support site at http://epsupport.elsevier.com
for more information.
Submission
Submission to this journal proceeds totally
online and you will be guided stepwise through the creation and uploading of your files. The system automatically converts source files
to a single PDF file of the article, which is used in the peer-review process. Please note that even though manuscript source files are
converted to PDF files at submission for the review process, these source files are needed for further processing after acceptance. All
correspondence, including notification of the Editor's decision and requests for revision, takes place by e-mail removing the need for
a paper trail.
Reviewers
Please submit, with the manuscript, the
names, addresses and e-mail addresses of 3 potential reviewers. Note that the editor retains the sole right to decide whether or not
the suggested reviewers are used.
Use of wordprocessing software
It is important that the file be saved in the native format of the wordprocessor
used. The text should be in single-column format. Keep the layout of the text as simple as possible. Most formatting codes will be removed
and replaced on processing the article. In particular, do not use the wordprocessor's options to justify text or to hyphenate words.
However, do use bold face, italics, subscripts, superscripts etc. Do not embed "graphically designed" equations or tables, but prepare
these using the wordprocessor's facility. When preparing tables, if you are using a table grid, use only one grid for each individual
table and not a grid for each row. If no grid is used, use tabs, not spaces, to align columns. The electronic text should be prepared
in a way very similar to that of conventional manuscripts (see also the Guide to Publishing with Elsevier: http://www.elsevier.com/guidepublication).
Do not import the figures into the text file but, instead, indicate their approximate locations directly in the electronic text and on
the manuscript. See also the section on Electronic illustrations.
To avoid unnecessary errors you are strongly advised to use the
"spell-check" and "grammar-check" functions of your wordprocessor.
Article structure
Subdivision - numbered sections
Divide your article into clearly
defined and numbered sections. Subsections should be numbered 1.1 (then 1.1.1, 1.1.2, ...), 1.2, etc. (the abstract is not included in
section numbering). Use this numbering also for internal cross-referencing: do not just refer to "the text". Any subsection may be given
a brief heading. Each heading should appear on its own separate line.
Introduction
State the objectives of the work and provide an adequate background, avoiding a detailed literature survey or a summary of the results.
Material and methods
Provide sufficient detail to allow the work to be reproduced. Methods already
published should be indicated by a reference: only relevant modifications should be described.
Theory/calculation
A Theory section should extend, not repeat, the background to the article already dealt with in
the Introduction and lay the foundation for further work. In contrast, a Calculation section represents a practical development from
a theoretical basis.
Results
Results should be clear and concise.
Discussion
This should explore the significance of the results of the work, not repeat them. A combined
Results and Discussion section is often appropriate. Avoid extensive citations and discussion of published literature.
Conclusions
The main conclusions of the study may be presented in a short Conclusions section, which
may stand alone or form a subsection of a Discussion or Results and Discussion section.
Appendices
If there is more than one appendix, they should be identified as A, B, etc. Formulae and equations in
appendices should be given separate numbering: Eq. (A.1), Eq. (A.2), etc.; in a subsequent appendix, Eq. (B.1) and so on.
Essential title page information
•
Title.
Concise and informative. Titles are often
used in information-retrieval systems. Avoid abbreviations and formulae where possible.
•
Author names and affiliations.
Where the family name may be ambiguous (e.g., a double name), please indicate this clearly. Present the authors' affiliation addresses
(where the actual work was done) below the names. Indicate all affiliations with a lower-case superscript letter immediately after the
author's name and in front of the appropriate address. Provide the full postal address of each affiliation, including the country name,
and, if available, the e-mail address of each author.
•
Corresponding author.
Clearly indicate who will handle
correspondence at all stages of refereeing and publication, also post-publication. Ensure that telephone and fax numbers (with country
and area code) are provided in addition to the e-mail address and the complete postal address.
•
Present/permanent
address.
If an author has moved since the work described in the article was done, or was visiting at the time, a "Present address"
(or "Permanent address") may be indicated as a footnote to that author's name. The address at which the author actually did the work
must be retained as the main, affiliation address. Superscript Arabic numerals are used for such footnotes.
Abstract
A concise and factual abstract is required. The abstract should state briefly the purpose of the
research, the principal results and major conclusions. An abstract is often presented separately from the article, so it must be able
to stand alone. For this reason, References should be avoided, but if essential, then cite the author(s) and year(s). Also, non-standard
or uncommon abbreviations should be avoided, but if essential they must be defined at their first mention in the abstract itself.
Keywords
Immediately after the abstract, provide a maximum of 6 keywords, using American spelling and avoiding
general and plural terms and multiple concepts (avoid, for example, "and", "of"). Be sparing with abbreviations: only abbreviations firmly
established in the field may be eligible. These keywords will be used for indexing purposes.
Abbreviations
Define abbreviations that are not standard in this field in a footnote to be placed on the first page of
the article. Such abbreviations that are unavoidable in the abstract must be defined at their first mention there, as well as in the
footnote. Ensure consistency of abbreviations throughout the article.
Acknowledgements
Collate acknowledgements in a separate section at the end of the article before the references and do not, therefore, include
them on the title page, as a footnote to the title or otherwise. List here those individuals who provided help during the research (e.g.,
providing language help, writing assistance or proof reading the article, etc.).
Math
formulae
Present simple formulae in the line of normal text where possible and use the solidus (/) instead of a horizontal
line for small fractional terms, e.g., X/Y. In principle, variables are to be presented in italics. Powers of e are often more conveniently
denoted by exp. Number consecutively any equations that have to be displayed separately from the text (if referred to explicitly in the
text).
Footnotes
Footnotes should be used sparingly. Number them consecutively
throughout the article, using superscript Arabic numbers. Many wordprocessors build footnotes into the text, and this feature may be
used. Should this not be the case, indicate the position of footnotes in the text and present the footnotes themselves separately at
the end of the article. Do not include footnotes in the Reference list.
Table footnotes
Indicate each footnote in a
table with a superscript lowercase letter.
Artwork
Electronic artwork
General points
• Make sure you use uniform lettering and sizing
of your original artwork.
• Save text in illustrations as "graphics" or enclose the font.
• Only use the following
fonts in your illustrations: Arial, Courier, Times, Symbol.
• Number the illustrations according to their sequence in the text.
• Use a logical naming convention for your artwork files.
• Provide captions to illustrations separately.
•
Produce images near to the desired size of the printed version.
• Submit each figure as a separate file.
A detailed guide
on electronic artwork is available on our website:
http://www.elsevier.com/artworkinstructions
You are urged
to visit this site; some excerpts from the detailed information are given here.
Formats
Regardless of the application
used, when your electronic artwork is finalised, please "save as" or convert the images to one of the following formats (note the resolution
requirements for line drawings, halftones, and line/halftone combinations given below):
EPS: Vector drawings. Embed the font or save
the text as "graphics".
TIFF: color or grayscale photographs (halftones): always use a minimum of 300 dpi.
TIFF: Bitmapped line
drawings: use a minimum of 1000 dpi.
TIFF: Combinations bitmapped line/half-tone (color or grayscale): a minimum of 500 dpi is required.
DOC, XLS or PPT: If your electronic artwork is created in any of these Microsoft Office applications please supply "as is".
Please
do not:
• Supply embedded graphics in your wordprocessor (spreadsheet, presentation) document;
• Supply files that
are optimised for screen use (like GIF, BMP, PICT, WPG); the resolution is too low;
• Supply files that are too low in resolution;
• Submit graphics that are disproportionately large for the content.
Color
artwork
Please make sure that artwork files are in an acceptable format (TIFF, EPS or MS Office files) and with the correct
resolution. If, together with your accepted article, you submit usable color figures then Elsevier will ensure, at no additional charge,
that these figures will appear in color on the Web (e.g., ScienceDirect and other sites) regardless of whether or not these illustrations
are reproduced in color in the printed version. For color reproduction in print, you will receive information regarding the costs
from Elsevier after receipt of your accepted article. Please indicate your preference for color in print or on the Web only. For
further information on the preparation of electronic artwork, please see http://www.elsevier.com/artworkinstructions.
Please
note: Because of technical complications which can arise by converting color figures to "gray scale" (for the printed version should
you not opt for color in print) please submit in addition usable black and white versions of all the color illustrations.
Figure captions
Ensure that each illustration has a caption. Supply captions separately, not attached
to the figure. A caption should comprise a brief title (not on the figure itself) and a description of the illustration. Keep
text in the illustrations themselves to a minimum but explain all symbols and abbreviations used.
Tables
Number tables consecutively in accordance with their appearance in the text. Place footnotes to tables below the
table body and indicate them with superscript lowercase letters. Avoid vertical rules. Be sparing in the use of tables and ensure that
the data presented in tables do not duplicate results described elsewhere in the article.
References
Citation in text
Please ensure that every reference
cited in the text is also present in the reference list (and vice versa). Any references cited in the abstract must be given in full.
Unpublished results and personal communications are not recommended in the reference list, but may be mentioned in the text. If these
references are included in the reference list they should follow the standard reference style of the journal and should include a substitution
of the publication date with either "Unpublished results" or "Personal communication" Citation of a reference as "in press" implies that
the item has been accepted for publication.
Web references
As a minimum,
the full URL should be given and the date when the reference was last accessed. Any further information, if known (DOI, author names,
dates, reference to a source publication, etc.), should also be given. Web references can be listed separately (e.g., after the reference
list) under a different heading if desired, or can be included in the reference list.
References in a special issue
Please ensure that the words 'this issue' are added to any references in the list (and
any citations in the text) to other articles in the same Special Issue.
Reference
management software
This journal has standard templates available in key reference management packages EndNote ( http://www.endnote.com)
and Reference Manager ( http://www.refman.com). Using plug-ins to wordprocessing packages, authors only need to select the
appropriate journal template when preparing their article and the list of references and citations to these will be formatted according
to the journal style which is described below.
Reference style
Text:
Indicate references by number(s) in square brackets in line with the text. The actual authors can be referred to, but the reference number(s)
must always be given.
Example: "..... as demonstrated [3,6]. Barnaby and Jones [8] obtained a different result ...."
List:
Number the references (numbers in square brackets) in the list in the order in which they appear in the text.
Examples:
Reference to a journal publication:
[1] J. van der Geer, J.A.J. Hanraads, R.A. Lupton, The art of writing a scientific article,
J. Sci. Commun. 163 (2000) 51-59.
Reference to a book:
[2] W. Strunk Jr., E.B. White, The Elements of Style, third ed., Macmillan,
New York, 1979.
Reference to a chapter in an edited book:
[3] G.R. Mettam, L.B. Adams, How to prepare an electronic version of
your article, in: B.S. Jones, R.Z. Smith (Eds.), Introduction to the Electronic Age, E-Publishing Inc., New York, 1999, pp. 281-304.
Journal abbreviations source
Journal names should be abbreviated according to
Index Medicus journal
abbreviations: http://www.nlm.nih.gov/tsd/serials/lji.html;
List of serial title word abbreviations: http://www.issn.org/2-22661-LTWA-online.php;
CAS (Chemical Abstracts Service): http://www.cas.org/sent.html.
Video
data
Elsevier accepts video material and animation sequences to support and enhance your scientific research. Authors who
have video or animation files that they wish to submit with their article are strongly encouraged to include these within the body of
the article. This can be done in the same way as a figure or table by referring to the video or animation content and noting in the body
text where it should be placed. All submitted files should be properly labeled so that they directly relate to the video file's content.
In order to ensure that your video or animation material is directly usable, please provide the files in one of our recommended file
formats with a maximum size of 30 MB and running time of 5 minutes. Video and animation files supplied will be published online in the
electronic version of your article in Elsevier Web products, including ScienceDirect: http://www.sciencedirect.com. Please
supply 'stills' with your files: you can choose any frame from the video or animation or make a separate image. These will be used instead
of standard icons and will personalize the link to your video data. For more detailed instructions please visit our video instruction
pages at http://www.elsevier.com/artworkinstructions. Note: since video and animation cannot be embedded in the print version
of the journal, please provide text for both the electronic and the print version for the portions of the article that refer to this
content.
Supplementary data
Elsevier accepts electronic supplementary
material to support and enhance your scientific research. Supplementary files offer the author additional possibilities to publish supporting
applications, high-resolution images, background datasets, sound clips and more. Supplementary files supplied will be published online
alongside the electronic version of your article in Elsevier Web products, including ScienceDirect: http://www.sciencedirect.com.
In order to ensure that your submitted material is directly usable, please provide the data in one of our recommended file formats. Authors
should submit the material in electronic format together with the article and supply a concise and descriptive caption for each file.
For more detailed instructions please visit our artwork instruction pages at http://www.elsevier.com/artworkinstructions.
Submission checklist
It is hoped that this list will be useful during the final checking of an article prior
to sending it to the journal's Editor for review. Please consult this Guide for Authors for further details of any item.
Ensure
that the following items are present:
One Author designated as corresponding Author:
• E-mail address
• Full
postal address
• Telephone and fax numbers
All necessary files have been uploaded
• Keywords
• All figure
captions
• All tables (including title, description, footnotes)
Further considerations
• Manuscript has been "spellchecked"
and "grammar-checked"
• References are in the correct format for this journal
• All references mentioned in the Reference
list are cited in the text, and vice versa
• Permission has been obtained for use of copyrighted material from other sources
(including the Web)
• Color figures are clearly marked as being intended for color reproduction on the Web (free of charge)
and in print or to be reproduced in color on the Web (free of charge) and in black-and-white in print
• If only color on the
Web is required, black and white versions of the figures are also supplied for printing purposes
For any further information please
visit our customer support site at http://epsupport.elsevier.com..
Editorial timeline
The editors will make every effort to reach decisions on submitted papers within
4 weeks of the submission date. If revisions are a condition of publication, we generally allow two months for revisions and consider
only one revised version of the paper. Evaluations of conceptual advance and significance are made based on the literature available
on the day of the final decision, not the day of submission. Any major changes after acceptance are subject to review and may delay publication.
Use of the Digital Object Identifier
The
Digital Object Identifier (DOI) may be used to cite and link to electronic documents. The DOI consists of a unique alpha-numeric character
string which is assigned to a document by the publisher upon the initial electronic publication. The assigned DOI never changes. Therefore,
it is an ideal medium for citing a document, particularly 'Articles in press' because they have not yet received their full bibliographic
information. The correct format for citing a DOI is shown as follows (example taken from a document in the journal Physics Letters
B):
doi:10.1016/j.physletb.2003.10.071
When you use the DOI to create URL hyperlinks to documents on the web, they are guaranteed
never to change.
Proofs
One set of page proofs (as PDF files) will be
sent by e-mail to the corresponding author (if we do not have an e-mail address then paper proofs will be sent by post) or, a link will
be provided in the e-mail so that authors can download the files themselves. Elsevier now provides authors with PDF proofs which can
be annotated; for this you will need to download Adobe Reader version 7 (or higher) available free from http://www.adobe.com/products/acrobat/readstep2.html.
Instructions on how to annotate PDF files will accompany the proofs (also given online). The exact system requirements are given at the
Adobe site: http://www.adobe.com/products/acrobat/acrrsystemreqs.html#70win.
If you do not wish to use the PDF annotations
function, you may list the corrections (including replies to the Query Form) and return them to Elsevier in an e-mail. Please list your
corrections quoting line number. If, for any reason, this is not possible, then mark the corrections and any other comments (including
replies to the Query Form) on a printout of your proof and return by fax, or scan the pages and e-mail, or by post. Please use this proof
only for checking the typesetting, editing, completeness and correctness of the text, tables and figures. Significant changes to the
article as accepted for publication will only be considered at this stage with permission from the Editor. We will do everything possible
to get your article published quickly and accurately. Therefore, it is important to ensure that all of your corrections are sent back
to us in one communication: please check carefully before replying, as inclusion of any subsequent corrections cannot be guaranteed.
Proofreading is solely your responsibility. Note that Elsevier may proceed with the publication of your article if no response is received.
Offprints
The corresponding author, at no cost, will be provided with a PDF file of the article via e-mail.
For an extra charge, paper offprints can be ordered via the offprint order form which is sent once the article is accepted for publication.
The PDF file is a watermarked version of the published article and includes a cover sheet with the journal cover image and a disclaimer
outlining the terms and conditions of use.
Distribution of materials and data
One of the terms and conditions of publishing in Molecular Oncology is that authors be willing to distribute any materials
and protocols used in the published experiments to qualified researchers for their own use. Materials include, but are not limited to,
cells, DNA, antibodies, reagents, organisms, and mouse strains or, if necessary, the relevant ES cells. These must be made available
with minimal restrictions and in a timely manner, but it is acceptable to request reasonable payment to cover the cost of maintenance
and transport of materials. If there are restrictions to the availability of any materials, data, or information, these must be disclosed
in the cover letter and the experimental procedures section of the manuscript at the time of submission. Nucleic acid and protein sequences,
macromolecular structures determined by X-ray crystallography (along with structure factors), and microarray data must be deposited in
the appropriate public database and must be accessible without restriction from the date of publication. An entry name or accession number
must be included at the last paragraph of the Experimental Procedures section in the final version of the manuscript. Microarray data
should be MIAME compliant (for guidelines see http://www.mged.org/Workgroups/MIAME/miame.html).
In addition to the information
that must be deposited in public databases as detailed above, authors are encouraged to contribute additional information to the appropriate
databases. Authors are also encouraged to deposit materials used in their studies to the appropriate repositories for distribution to
researchers.
Open Archive
Molecular Oncology papers are
freely available starting 12 months after publication.
For
inquiries relating to the submission of articles (including electronic submission where available) please visit this journal's homepage.
You can track accepted articles at http://www.elsevier.com/trackarticle and set up e-mail alerts to inform you of when
an article's status has changed. Also accessible from here is information on copyright, frequently asked questions and more. Contact
details for questions arising after acceptance of an article, especially those relating to proofs, will be provided by the publisher.
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