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Editorial Board
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Exploitation of the propulsive force of chemotherapy for improving the response to cancer immunotherapy
09 December 2011
Abstract: Since the early clinical studies of cancer immunotherapy, the question arose as to whether it was possible to combine it with standard cancer treatments, mostly chemotherapy. The answer, now...
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Enrico Proietti,
Federica Moschella,
Imerio Capone,
Filippo Belardelli
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1-14
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Drug development to overcome resistance to EGFR inhibitors in lung and colorectal cancer
14 December 2011
Abstract: Epidermal growth factor receptor (EGFR) is a validated target in different human malignancies. EGFR tyrosine kinase inhibitors (TKIs) are known to contribute considerably to the extension of...
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Rodrigo Dienstmann,
Sara De Dosso,
Enriqueta Felip,
Josep Tabernero
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15-26
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Systems pathology: A critical review
05 December 2011
Abstract: The technological advances of the last twenty years together with the dramatic increase in computational power have injected new life into systems-level thinking in Medicine. This review emp...
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Jose Costa
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27-32
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uPA and uPAR shRNA inhibit angiogenesis via enhanced secretion of SVEGFR1 independent of GM-CSF but dependent on TIMP-1 in endothelial and glioblastoma cells
08 December 2011
Abstract: The uPA/uPAR system is known to play a critical role in angiogenesis of glioblastoma. Previously, we have shown that shRNA against uPA and uPAR attenuates angiogenesis by blocking nuclear tr...
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Hari Raghu,
Arun Kumar Nalla,
Christopher S. Gondi,
Meena Gujrati,
Dzunh H. Dinh,
Jasti S. Rao
et al.
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33-47
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CRABP-II methylation: A critical determinant of retinoic acid resistance of medulloblastoma cells
02 December 2011
Abstract: Medulloblastoma cells exhibit varied responses to therapy by all-trans retinoic acid (RA). The underlying mechanism for such diverse effects however remains largely unclear. In this study, w...
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Yuan-Shan Fu,
Qian Wang,
Jing-Xin Ma,
Xiang-Hong Yang,
Mo-Li Wu,
Kai-Li Zhang,
Qing-You Kong,
Xiao-Yan Chen,
Yuan Sun,
Nan-Nan Chen,
Xiao-Hong Shu,
Hong Li,
Jia Liu
et al.
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48-61
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Atorvastatin reduces vascular endothelial growth factor (VEGF) expression in human non-small cell lung carcinomas (NSCLCs) via inhibition of reactive oxygen species (ROS) production
30 November 2011
Abstract: The high metastatic potential of non-small cell lung cancers (NSCLCs) is closely correlated with the elevated expression of vascular endothelial growth factor (VEGF) and resultant tumor angi...
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Jie Chen,
Bing Liu,
Jiayi Yuan,
Jie Yang,
Jingjie Zhang,
Yu An,
Lu Tie,
Yan Pan,
Xuejun Li
et al.
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62-72
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Down-regulation of tumor suppressor MTUS1/ATIP is associated with enhanced proliferation, poor differentiation and poor prognosis in oral tongue squamous cell carcinoma
28 November 2011
Abstract: Microtubule-associated tumor suppressor gene (MTUS1, also known as mitochondrial tumor suppressor) is a recently identified tumor suppressor gene that has been implicated in several cancer t...
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Xueqiang Ding,
Ningning Zhang,
Yushen Cai,
Su Li,
Chaoxu Zheng,
Yi Jin,
Tianwei Yu,
Anxun Wang,
Xiaofeng Zhou
et al.
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73-80
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Aquaporins mediate the chemoresistance of human melanoma cells to arsenite
21 November 2011
Abstract: The integral membrane channel protein aquaporin (AQP) is aberrantly expressed with oncogenic characteristics in various human cancers. In this study, we analyzed the expression pattern of al...
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Lin Gao,
Yanhui Gao,
Xiaobo Li,
Paul Howell,
Rajeev Kumar,
Xiulan Su,
Alexander V. Vlassov,
Gary A. Piazza,
Adam I. Riker,
Dianjun Sun,
Yaguang Xi
et al.
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81-87
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Lack of independent prognostic and predictive value of centromere 17 copy number changes in breast cancer patients with known HER2 and TOP2A status
05 December 2011
Abstract: The clinical benefit of anthracyclines has been connected to HER2 status, TOP2A status and centromere 17 copy numbers (CEN-17). Data from a clinical trial randomizing patients to anthracycli...
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Kirsten Vang Nielsen,
Bent Ejlertsen,
Susanne Møller,
Maj-Britt Jensen,
Eva Balslev,
Sven Müller,
Ann Knoop,
Henning T. Mouridsen
et al.
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88-97
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Genomic imbalances in endometrial adenocarcinomas – Comparison of DNA ploidy, karyotyping and comparative genomic hybridization
28 October 2011
Abstract: DNA ploidy analysis is useful for prognostication in cancer patients, but the genomic details underlying ploidy changes are not fully understood. To improve this understanding, we compared D...
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Wanja Kildal,
Francesca Micci,
Bjørn Risberg,
Vera M. Abeler,
Gunnar B. Kristensen,
Sverre Heim,
Håvard E. Danielsen
et al.
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98-107
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